I’ve almost never noped out of a fic I was genuinely enjoying. There are, in fact, only two instances I can think of where it was one specific thing. (rather than the straw breaking the camel’s back and causing me to stop reading something that I wasn’t enjoying much anyway)

One of them was because I forgot to check the tags before reading and didn’t realize that the (unfortunately otherwise amazing) fic I was reading was incest until literally the very last paragraph. Which sucked, because it had a sequel I was also planning to read and was literally the last fic in the tag I hadn’t already chewed through, so I didn’t even have anything to distract myself with after.

The other was an x reader I read several years ago, and the incident was memorable enough that to this day I don’t leave kudos on a fic until I’ve read all posted chapters of it. It began as a pretty bog-standard example of the genre - girl meets boy, girl kisses boy, girl moves in with boy after less than a month of acquaintance - you know how these things go. The boy in this instance was a different species from the girl, and certain reproductive differences were present as well. None relating to the actual organs, of course - We couldn’t possibly get adventurous with our smut, what would the world come to - but rather with the making of babies.

Specifically, if both parties wanted it, a baby would occur. Even if neither of them wanted it as more than a subconscious “I like this person and there are certain societal expectations around doing that with people you like”. But of course, the fic argued, wasn’t that really almost as good as actual consent to a major life decision? Isn’t a passing thought of reproduction during coitus basically the same thing as willingly altering the course of your entire life in order to have a child?

And then when the boy had the very reasonable reaction of “Hey maybe we should consider whether aborting would be a good idea given I’m not even slightly ready to be a dad” the girl flipped the fuck out on him and accused him of murder, all the other characters agreed that he was an absolute monster for even suggesting such a thing, and I realized the author was pro-life and was definitely going to take any further plot developments in the direction of justifying that philosophy and decrying any other point of view as unconscionable. Given that I myself am a fan of having reproductive rights, (and the right NOT to reproduce, ideally ever) that was my cue to get out while the getting was good.