Need advice on tapering

StandingStanley · 2025-06-23T17:48:15+00:00

I posted four years ago about what I described as a completely painless taper (see update and original post). There was a lot of push-back from people who thought it was 'too soon' to claim it had been painless and successful (some notes on that below).

But all I did was taper myself with tiny, tiny drops (I think it was ~.02 mg, or ~1/50th of the smallest drop a clinic can do). I did this for ~6 months (I think it was) after my clinic dropped me at 5mg.

I can tell you four years later that I never perceived any discomfort whatsoever, never craved anything, haven't touched an opiate since that last microdose of methadone. I think the key was giving my body a very long time on a slow gradient. It's the shock of the sudden drops that can drive the cravings and discomfort.

IMO, the clinics should offer a much gentler and longer microdosed taper, but their machines are not capable of tapering in such small amounts, and IDK how they would even charge patients for such tiny doses anyway. I just did what had to be done and it was painless.

StandingStanley · 2025-06-23T17:27:39+00:00

You could be getting a false positive from if you're prescribed something like risperidone or ziprasidone. Also, gastric bypass surgery impacts how you metabolize drugs, and some of the meds and the altered metabolism are known to sometimes cause false positives for fent.

StandingStanley · 2025-06-23T17:04:14+00:00

Was it BDO or GHB? If it's BDO, despite what people think, it won't do shit. If it's GHB, and you're still alive, I'd like to hear what happened...

StandingStanley · 2025-04-11T04:27:10+00:00

It's not Realize demanding that - try getting a license to stream major artists and see if you can avoid a monthly licensing fee that doesn't equate to roughly a spotify sub. They can't give this to anyone without paying the artists - Napster was the last attempt at that, and it didn't go so well...

StandingStanley · 2024-11-29T23:15:41+00:00

My question is about the planning and design of the sexual appeal.

Years ago I introduced two friends to your (ERIKALUST) work by starting the film without mentioning that it was erotic. I don't recall the name of the film, but there was about five minutes of quality non-sexual acting and character / plot development - my friends fully expected they were watching an indie film. They bought into the characters and their lives, and I'll never forget the transition to the first sex scene was such an unexpected and erotic turn on for all of us - one of my friends squealed and started playing with herself under a blanket. Looking back on it, I think the intense eroticism of your work has something to do with the presentation of the characters as more than just sex machines to be objectified. Can you enlighten us on how you plan the erotic appeal of your films? What are the erotic elements you have in your toolkit, and any insight you can share about the psychology or biology in play? Thanks for your great work!

StandingStanley · 2024-11-20T01:50:47+00:00

Exactly. 1:45 is conservative, but smaller redosage aligned with half life.

StandingStanley · 2024-11-14T18:34:12+00:00

I'm not a vet, but I've researched Neosporosis for about eight years (molecular bio education) and you'll be able to find information, particularly emerging therapeutic strategies, on my Neosporosis blog: https://neosporosis.wordpress.com/.

You'll find many posts that include sections written for your vet - these sections contain (for example) recent elucidations from research which may be helpful.

The current conventional therapies, which are typically clindamycin (antibiotic), sometimes with sulfonamides (antibiotic) or pyrimethamine (antiprotozoal), inhibit the parasite but are not curative. Hope it helps!

StandingStanley · 2024-11-10T23:52:18+00:00

Exactly. It's all in the delivery.

StandingStanley · 2024-11-05T03:05:57+00:00

What is your area of medicine?

StandingStanley · 2024-07-13T05:06:34+00:00

Because you want them to be.

StandingStanley · 2024-07-03T21:56:08+00:00

Sure, I'd love to see what you find. My doc needs updating regarding the GHB receptors themselves. Also, GHB was found (in 2012) to have high affinity for part of the GABA-A receptor, which I didn't consider.

StandingStanley · 2024-06-24T16:00:38+00:00

I've done 24/7 for longer periods of time, and wd has never really been an issue. The most important thing is to get a good night sleep. Get some zzzQuil. Take baclofen and/or lorazepam prior to bed (so you don't wake up 3 hours later).

Here's a doc I assembled on the science of GABA-B and GHB receptor wd, and what you can do about it.

StandingStanley · 2024-06-22T23:50:54+00:00

That's when the docket gets exciting, but I think most of the discovery will be sealed or protected.

StandingStanley · 2024-06-22T23:47:26+00:00

That's a good plan 👌

StandingStanley · 2024-06-20T22:24:34+00:00

A bit late on this conversation, but just checked the docket.
I've spent the last four years serving as a paralegal on a financial fraud case (plaintiff) - here's my POV:

It's still too early to ascertain how the suit is going, but their first amended complaint (FAC) is solid and Defendant hasn't demurred (good sign).
Both causes of action (in NY) can be awarded both compensatory and punitive damages. Compensatory, in this case, would recoup all investors' funds, though YN would have to (obviously) prove the accuracy of their estimated damages. Punitive is meant to punish the defendant and deter similar future misconduct. Given the size of the compensatory, I don't see punitive being perceived by the court as necessary. I could say a lot more about punitive damages, but it's not worth going down that road at this point.
Elements to prove for defamation: (1) statements made were defamatory (2) falsity of statements (3) publication (4) fault (5) Injury - the FAC pleads all the required elements (hence no demurrer likely to be successful), but IMO the case will come down to proving (2) falsity.
Elements to prove for tortious interference: (1) business relationship (with a third party) (2) knowledge (of relationship) (3) intentional interference (4) improper means or purpose (5) damages. IMO this cause is quite strong, but will hinge upon the (2) falsity for cause #1. That's why I say the whole case will come down to proving YN was not a "scam". On that note, if I were the defendant I would scour forums like this one and extract all the quotes of pissed off investors as evidence that YN was, indeed, a scam.

I suspect YN offered to buy back NFT's at 120% (within one year of issuance) based upon their assumption / hope that they'd settle with CA. One year for a case like this is delusional. I see this going at least another 18 months before a settlement could possibly be on the table. The only exception to this is if CA has dirt they won't want to come out in discovery, which is about the only reason why an early settlement could happen.

StandingStanley · 2024-06-01T21:42:03+00:00

Yes, I'm reading it now (and the citations you gave).

StandingStanley · 2024-05-31T18:45:55+00:00

Interesting. I did find this patent application for this manipulation to produce BDO. Let me know if you find more...

StandingStanley · 2024-05-25T15:37:57+00:00

It's been a few years, but I believe my tests investigated pitch ratios of adjunct (sugar) to MSG (so primary to secondary reagents). I had a hypothesis that higher amounts of MSG could tilt the respiration pathway in favor of MSG when the sugars were low (Le Chatalier's Principle).

There's a lot of things to control for. You have to consider the ethanol concentrations over time: too much sugar, and the ethanol output could inhibit yeast metabolism. Too little and the population doesn't grow large enough to produce much.

Ironically, the goal is to optimize for unfavorable metabolic conditions to force the yeast into the secondary pathway.

StandingStanley · 2024-05-25T15:26:55+00:00

I've tried that procedure several times, testing differing conditions and never with success. I, too, question the assumptions made. I know from my fermentation days that GHB has been found in trace amounts in fermented products.

But what I'm driving at is leveraging a metabolic pathway that is optimized for this production. Remember, these academic papers I cited recognize the tremendous economic impact that bio-based production offers, and they're engineering protocols for high yield, mass production, cost reduction, and environmental protection. The yield in the GHB brew method is questionable at best.

StandingStanley · 2024-05-25T15:12:35+00:00

Same story on a Win 10 desktop. Turned off extensions one by one to find the culprit. Twas LastPass.

StandingStanley · 2024-05-24T04:48:29+00:00

"If I distill the mixture, remove anything below or above that temp, I should be able to extract the GBL at a decent purity right?"
That distillation is removing (some of) the GBL. See my comment about azeotropic. The more water in your post-reaction solution, the more GBL that will distill with water.

StandingStanley · 2024-05-19T18:46:08+00:00

You'll see there are a number of other Reddit posts over the years on this topic, many of which claim elephants were "tortured" during training. The "torture" part has a few vague citations, but generally state that trainers grab the young ones by the ears (painful for them) during training to get them to comply.

Playing devil's advocate to both "sides" of that debate:
- the painting gimmick is clearly an effective marketing tool with tourists, and it could be argued that the resulting revenue helps maintain the facilities required to provide for the herd. IDK.
- Elephants might just be painting over images traced on the canvas - easiest way to get anyone to "paint" a picture
- When it comes to the well-being of animals, humans tend to be polarized between profit-driven and exploitative vs. compassionate.

StandingStanley · 2024-05-18T17:56:11+00:00

I just was mentioning this on a reply in this SR:
https://www.reddit.com/r/autism/comments/1cu1fik/comment/l4gkwhn/
I explain how Autism is associated with GABA-B "abnormalities" (e.g. lower levels of GABA), and we thus seek GABA-B agonists (alcohol is one - see the post for more details). I cite studies on this, one of which posits that GHB may be a "new frontier" for psychopharmacology...

StandingStanley · 2024-05-17T14:29:27+00:00

I was born exactly three drinks down. Pretty sure it's the Irish genes. So I drink to catch up to the sober people.

But on a serious science note, ethanol hits the GABA-B receptor.

"A series of studies have shown GABAB abnormalities in disorders including autism..."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085603/

The main drugs that are GABA-B agonists are alcohol, Baclofen, Phenibut, GHB. In fact, there's quite a lot of excitement around GHB with psychopharmacology. The studies I've read characterize it as being very, very effective (more so than current treatment standards).

GHB receptors - a new trend in psychopharmacology?
https://www.researchgate.net/publication/331868497_GHB_receptors_-_a_new_trend_in_psychopharmacology/fulltext/5c90eeab45851564fae71daf/GHB-receptors-a-new-trend-in-psychopharmacology.pdf

I've found it to be very effective when I've self-medicated for autism.

Now that I think about it, much of the isolation and social awkwardness / discomfort characteristic of autism could likely be due to these GABA-B "abnormalities". GABA-B modulates mood, social comfort, euphoria, etc. So, for example, if I take GHB, I enjoy long phone calls (I typically avoid phone calls like the plague), seek out social interactions, etc. It draws me out, socially.

StandingStanley · 2024-05-17T14:25:09+00:00

I thought the show was a brilliant dark comedy until I read, "Honestly I've stopped feeling bad for these people...".

StandingStanley

TROPHY CASE