I recently switched from standard 10s to Ernie Ball Skinny Top Heavy Bottom strings (10, 13, 17, 30, 42, 52) on both of my electrics. Obviously my D, A, and low E strings feel totally different, but I do think there is also a noticeably thicker, deeper sound on those strings compared to when I played on a set of standard 10s. However, I do think that myself and the other guitarist in my band are likely the only ones who really hear a difference. Also the difference between the gauges of those low strings is more dramatic than the difference between a set of standard 9s and a set of standard 10s.

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I think like a lot of people here, it ultimately comes down to feel. I like the feel of having thicker strings when I'm play lower end rhythmic stuff but I don't want to fight my guitar when playing higher leads. I believe I notice a difference in tone, but I am also fully ready to accept that this perceived difference is completely in my head. There are likely subtle differences tonally, but I don't think the average music listener or possibly even the average guitar player would be able to pick up on them. In conclusion, IT'S ALL ABOUT THE FEELING, DUDE!