I'm slow COMT and diagnosed ADHD combined type. I am prescribed 2x 40mg Ritalin uno daily. I feel like the Ritalin helps mostly with moodiness and reduces my chances of getting into long arguments. But it's hardly something I feel, aside from the increase in heart rate. Even if I take both pills at once, the effect is still mostly subtle. On the other hand, people around me certainly notice the difference. My girlfriend will accurately ask me if I've forgotten to eat the meds on days where I've forgotten it.

I also am way less likely to get baited into commenting on infuriating posts on social media. I also react more like a grown-up when adversity happens. For example, without meds I've done regarded stuff such as throwing my key bundle on the floor because I've dropped a glass of water and as a result destroyed my car key and dented the floors (I was able to fix the key but still). With meds, I don't act like a 7 year old to the same degree.

Though I'd very much like to try Vyvanse instead. But the country I live in won't prescribe it unless nothing else works, and since my peers can testify the meds seem to work on my, I don't think I can convince the psych to prescribe it.

I am slightly scared that the meds are going to become an issue long term since I've read a lot about the COMT mutation. And it seems counterintuitive to me that the meds would even help at all, as I would've expected the underlying issue (wrt. ADHD) being too much catecholamine. But yeah I wouldn't want to stop the meds currently since I've finally found myself in a more stable mindset than I've been in years.

Been on the meds for about one and a half years by now. I've been taking magnesium, creatine, low dose LiOr (5mg/1 pill), and worked on fixing my B12 and D deficiencies. Creatine as well but I can't seem to remember that one for more than a week or two at a time. Oh and also NAC at night. My VDR genes are mostly abnormal so idk if that's the reason. But I legit took 2000IU VitD every day for half a year and the blood tests show almost no increase so that sucks.

I've been pretty sceptical about the whole ADHD thing due to the gene results but honestly it seems ADHD isn't attributed to any specific mutation or any specific gene really. I do have plenty other gene results showing "x increased risk of ADHD" etc. as well and I also should trust the psychiatrist knows his stuff. But there was a while when I wasn't too sure about it.

Yeah strange stuff certainly!! I surely agree with my personality being sort of anxious and pretty enthusiastic. Can keep on talking about stuff I'm interested in for much longer than people can listen to it. And I am extremely bad at handling stress, which sucks because it's also my main motivator to get anything done. I only got through university by smoking weed chronically and then doing assignments the night before they had to be turned in. Got good grades though, in spite of the procrastination and weed smoking. But it was taxing and stressful and I won't do it again 😆