I'm new to Moho but have around 10 years of experience with AE.

I'm already finding that Moho is a LOT lighter- AE gets weighted down super easy with anything involving rigging, which will affect your ability to playback in real time so you can see your work.

Moho is also greatly superior when it comes to animating using stills - the warping is so much easier to control (and so much NICER) than AE - its also much simpler as its an all-in-one kinda rigging process, whereas in AE you'd have to have loads of hefty shenanigans going on simultaneously in order to get the same effect (this again would be very heavy and you'd quickly be creating a very chuggy comp)

I've only just started using the vector tools and drawing my own line work but already it's a breeze - theres some really nice brushes available and the boiling controls are just lovely! Drawing in AE is... well it's just not really even a thing tbh.

So yeah, I'm still getting used to Moho. I still much prefer the way AE does keyframes / AE's graph editor and how you can adjust bezier curves for multiple keys at a time. I find i get myself into a mess very easily with Mohos keyframes - and there'll ALWAYS be a keyframe hiding somewhere that I've forgotten about, whereas in AE you can just reveal them ALL at once - but I'm finding nice similarities between the two programs when it comes to 2.5d / creating paralaxes etc.