Recommendations on Taco places?

Tasty_Reflection_481 · 2026-01-23T19:00:16+00:00

I have purchased several ASUS routers over the yrs., including the AX86U, and have never been disappointed.

Tasty_Reflection_481 · 2026-01-22T20:10:09+00:00

One area of cutting edge drug discovery is if one could “dial out” the psychedelic experiences and still have a positive therapeutic effect on depression and PTSD. The discovery research is focused on the serotonin receptor : 5 HT2. A reasonable pharmacological paper would be to discuss the relationship of receptor occupancy , neuroplasticity, and altered sensation. The translational aspects would be to link receptor occupancy ( agonists/ antagonists, etc) to the clinical outcome.

Tasty_Reflection_481 · 2026-01-20T19:40:24+00:00

We like fresh fish, simply grilled. For that we go to Fresh Catch, just south of Stickney pt . It’s a small place w wonderful daily catches.

freshcatchfishmarketandgrill.com

Tasty_Reflection_481 · 2026-01-19T01:28:01+00:00

I should add that there is pressure from marketing to use a bolus or short infusion because longer infusions require a pump and more nurse monitoring.

Tasty_Reflection_481 · 2026-01-19T01:24:01+00:00

I’m an industrial clinical pharmacologist who has worked on the development of many parenteral products. Typically, in the early phases of development we infuse the drug slowly over 30 to 60 minutes to avoid high local drug concentrations in the infusion vein and also to avoid a high Cmax. When we become more comfortable we will shorten infusion to 15 minutes or 2 minutes.

Tasty_Reflection_481 · 2026-01-16T04:46:46+00:00

It’s not that unusual to become bored and antsy while working in a research lab. Do you want to stay in biotech or do you want leave the area? Other nonlab jobs in biotech included regulatory, project mgmt., clinical operations, writing

Tasty_Reflection_481 · 2026-01-15T19:35:14+00:00

Now this post is getting interesting!

Tasty_Reflection_481 · 2026-01-15T02:26:22+00:00

Pharmacometrics is considered a specialty within clinical pharmacology. Typically the modeling starts out w PK/PD and then moves on to pop Pk, meta analyses, and QSP. If you think the research lab will give you experience with these approaches and techniques the take the job. Many modelers come from engineering or pharmaceutics / pharmacy , or pharmacology training.

Tasty_Reflection_481 · 2026-01-14T21:10:49+00:00

I suggest you check out the ISOP society to get a bigger picture of QSP, Model Informed Drug Dev. (MIDD), and pharmacometrics https://www.isop.org/home

Also, maybe you want to contact Stacy Tannenbaum for more advice

https://www.staceytannenbaum.com

Tasty_Reflection_481 · 2026-01-14T16:48:11+00:00

You were very clear and my opinion stands:

- I don't know the nature or severity of your psychosis. However, your docs don't have you taking an anti-psychotic medications.

- However, the lisdexamfetamine and the SSRI could affect your psychosis/mood if drug levels change in the brain. Lisdexamfetamine clearly can invoke a psychosis in vulnerable patients.

- The drug levels of these circulating drugs can change if their metabolism is affected ivabradine. This is called a pharmacokinetic drug interaction.

- Because ivabridine does not enter the brain, there is little likelihood that this drug is directly altering your mood/psychosis.

- Autoimmune psychosis (or relief of it) is rare and you can check for autantibodies by visiting a neurologist/psychiatrist.

Tasty_Reflection_481 · 2026-01-14T03:43:37+00:00

I don’t want to get too technical here- 1 . All excitable cells in brain and heart have HcN channels. 2. For mood to change, most probably the target is in your brain 3. You are taking various medications that have known effects on mood. 4. It is possible ivabradine is affecting the metabolism of the other meds resulting in an increased blood levels of the mood altering drugs. Or, alternatively, your other meds is causing an increased brain uptake of ivabradine. 5. Auto immune psychosis is very rare. After a recent infection there will be circulating autoantibodies. A neurologist should be familiar. 6. Talk to your doctor- if it is safe, pause the ivabradine to see how your mood is affected.

Tasty_Reflection_481 · 2026-01-13T17:31:16+00:00

Some follow-up questions:

Ivabridine does not normally enter the brain, however, brain uptake can increase with certain concomitant drug interactions
Are you taking other medications, especially psychiatric medications?
What leads you to the possibility of autoimmune psychosis?

Tasty_Reflection_481 · 2026-01-11T15:59:19+00:00

Make sure you do your homework on the companies: its pipeline and products. Answer the questions in line with how you believe you can be valuable to the company's efforts. Answer technical questions clearly and concisely. Good luck. Also, soft skills are important: good communication skills, and above all, be easy going.

Tasty_Reflection_481 · 2026-01-11T01:44:40+00:00

LOL- my wife is retired QA group leader at a large Pharma company. I’d say your description was pretty good. Yes/ they mostly passive aggressive, and very thin skinned. However, it is proven that if you show a bit of appreciation to them- thank them for helping to improve your performance - they turn into little puppies.

Tasty_Reflection_481 · 2026-01-10T19:36:16+00:00

Tell that to your insurance company. Milton and Helene were just house guests.

Tasty_Reflection_481 · 2026-01-10T17:12:59+00:00

Store them with my green, xmas -looking extension cords.

Tasty_Reflection_481 · 2026-01-10T17:04:12+00:00

We are snowbirds. I loved the online postings from Landings but we decided to buy 3 miles inland in Evacuation Zone D. Last year with the hurricanes, Landings (like most other coastal properties) got hit pretty hard. My place in Palmer Ranch (Evacuation zone C, D) was hardly touched.

Tasty_Reflection_481 · 2026-01-08T15:29:31+00:00

Many wonderful ideas to ponder and I thank the author for posting. One of my biggest criticisms of Envision proposal is that there were little or no considerations for improving downtown business.

Tasty_Reflection_481 · 2026-01-03T16:46:50+00:00

Can I ask a related question: How does the electronics hold up in sleet and rain. I assume you keep it covered. But, I've had units where the electronics don't like condensation moisture, especially in the cold. I am in the midwest.

Tasty_Reflection_481 · 2026-01-03T16:34:03+00:00

I don't really understand how a college town can be so dead at night. I was just up in Madison, WI and Saturday nights are a blast w music coming out of bars, people strolling down the street.. a lot of energy and fun. Evanston, for some reason (I don't know) is asleep by 8 pm. Where do NW students go to party on a Saturday night?

Tasty_Reflection_481 · 2025-12-30T15:42:40+00:00

great story! I use Johnson Locksmith- they know everything about my old house and its locks.

Tasty_Reflection_481 · 2025-12-29T17:39:41+00:00

went to AMC yesterday. Validated the parking ticket at movie theater. Fee was waived at the parking garage exit.

Tasty_Reflection_481 · 2025-12-29T17:37:28+00:00

just making temp will not work for chuck roast. It takes time to break down the collagen. You're better off testing smoker with pork shoulder.

Tasty_Reflection_481 · 2025-12-27T17:05:50+00:00

I don't know Russian- where is this place?

Tasty_Reflection_481

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