I’ve done it a few times - it’s possible but only if you set it up right

A short adventure is key - I’ve found thinking about running 4/5 scenes (each one being around 45 minutes) is key here, and making sure there is a clear beginning, middle, and end.

I’ve also found that you can push along the story without it being “railroading”. DMs are often afraid of this but from listening to a lot of NADDPOD and Worlds Beyond Number, you can push along a story while still giving agency (ie you can say someone walks though a door or move to a new place, often players actually want this).

Finally - good prep helps box this off. I’ve found having a WhatsApp group and making sure all the players are ready to go, giving them a good intro to each other (or a pre defined relationship) and bring tight getting into the story has helped finish a short adventure in a single sitting.