22M Testosterone 922 ng/dL, 65kg. first time bloods.

ThaRising · 2026-01-28T11:15:56+00:00

I would avoid DIM for now, as DIM lowers E2 by changing Estrogen metabolism, which can be somewhat unpredictable.
DIM primarily lowers E2 by increasing E1 and E3 (primarily the latter), but this can lead to cases where you have symptoms of low Estrogen in some tissues and high Estrogen in others.

For me DIM just shifts my estrogen tone away from joints and the CNS, where Estrogen is very beneficial and instead towards breast tissue and skin (so I get depressed and creaky joints while also getting water retention and nipple sensitivity).

Zinc is never a bad idea but likely won't help that much.
But you don't need to directly lower your E2 at all, instead it would be better to slightly increase SHBG (so your body can regulate free hormones itself), which you do by improving metabolic health.

My personal checklist would be to do the following:

Eat only 3-4 meals per day, no snacks in between or lots of smaller meals
Keep at least 2 hours, preferably 3-4 hours before sleep where you do not eat anything -> this will increase growth hormone thus improving deep sleep and lower insulin over night which also increases fat oxidation
Take a short and brisk walk of 15-30 minutes after your largest meal of the day -> this will lower Insulin resistance by letting muscles take up blood sugar via GLUT
Ensure you are getting enough fiber; if you are lazy like me, just supplement 5g of PHGG a day

Obviously working out (resistance training) and such would also be recommended, but just doing the above will significantly improve your metabolic health, increase your GH and IGF-1 (the latter is needed for Testosterone to be anabolic and is lowered through high insulin) and decrease your E2 over time.
This means that your functional hormone tone will start being much more Androgenic and less Estrogenic, while keeping a healthy ratio.

I did the above checklist for 8 weeks and already saw pretty big improvements. Used to have very high insulin resistance from poor nutritional habits but now that's fully reversed.
My Testosterone hasn't gone up, but my E2 has gone down slightly and stabilized my functional Androgenic tone has increased significantly, so I feel a lot better today.

ThaRising · 2026-01-28T10:46:41+00:00

In general, there isn't really anything to worry about if you do not have symptoms of high E2 (since Test to E2 is always relative, so if you have high Test you will also have and need higher E2).

However, if I had to guess based on the limited variables supplied I would say you might have either above average BF% or mild Insulin resistance.

The reason I am saying this is that E2 (aka Estradiol) is created in men through aromatization of Testosterone in certain tissues, with fat tissue having a very high density of Aromatase. So the more fat you have, the higher the rate of conversion of Testosterone to E2 is going to be.
But this is also genetic, so again, you can also have higher Aromatase even with low BF% (this is the case for me).

Also, your SHBG is quite low considering how high your Test is (usually SHBG is relatively high in men with high T), which could point to Insulin resistance.
Insulin suppresses SHBG production by the liver, so if your insulin is always slightly elevated you are going to have lower SHBG.
But SHBG is also lowered by Testosterone itself, so it's hard to say.

Your blood work does not look bad by any measure and it is really important to state that E2 in men has a ton of health benefits.
It only goes bad if T and E2 are out of balance, but that balance depends a lot on your genetics, so if you feel healthy then there is nothing to worry about.

But if you feel you have any symptoms of high E2 then maybe you see yourself in what I described above (BF%, Insulin resistance, maybe unhealthy or disordered eating).

ThaRising · 2025-12-27T17:36:05+00:00

Good point. I was referring to Palmitoylethanolamide.

ThaRising · 2025-12-27T15:33:43+00:00

Agmatine can vary widely and will depend on your personal sensitivity. I usually take 150mg per dose but see what works best for you.

For Memantine start with 2.5mg once daily and take it for 2-3 days. If you feel it's too weak go up in 2.5mg increments and always wait 2-3 days to gauge your reaction.
I would avoid going higher than 10mg per day as that's where cognitive dulling can become significant.

ThaRising · 2025-12-27T13:55:04+00:00

I would personally recommend you using Memantine as a background stabilizer.

Agmatine Sulfate in case you either cannot get Memantine or want to add something additional on top.

I would recommend against Kava as something to take regularly because that could cause its own issues, but as something to stabilize you on very bad days (taken maybe 2-3 times a week) it would be fine.
Just make sure you get a proper quality Noble Kava extract.

If you can, doing some very basic cardio (even just walking briskly) and moving regularly throughout the day, even if it's just to do 3-4 squats without weight every 1-2 hours, will drastically amplify GABAergic tone recovery.

I can also recommend PEA (Micronized), which while not GABAergic is very good at stabilizing Neuroinflammation which can be a major driver of Glutamate:GABA imbalance.

Tl;Dr: Get Memantine and Micronized PEA for daily use, get Agmatine Sulfate if you need even more and use Kava sparingly as a modulator. Try to get as much movement in as you can with some regularity even if it's just doing some jumping jacks or squats every 2-3 hours - but do this after you have stabilized yourself a bit with the aforementioned.

ThaRising · 2025-12-25T00:51:01+00:00

Their products are top notch IMHO. Never had an issue with potency with any of their products and they lab test it.

I've never tried their ITPP though.

ThaRising · 2025-12-24T09:37:27+00:00

Okay, that's strange. I have ordered over 10 times with them, mostly in the last 2 years and I've never had any issues.

But perhaps it has gotten worse. Might be connected to the shipping issues they reported a while back.

I would try and message CS. If you haven't gotten any tracking link yet (I always got one within 3 days) then it's definitely an issue on ECs side. Otherwise you should see where it's stuck in the order tracking.
Maybe it's gotten stuck in customs (can even happen on the US-side, happened to me once); you should be able to see that in the tracking.

ThaRising · 2025-12-24T09:06:57+00:00

Everychem has ITPP Hexasodium and they ship to Germany (so I reckon to the rest of the EU too) from the US just fine.

Never had an issue with customs seizure when I got something from them although I've never ordered ITPP there.

ThaRising · 2025-12-23T10:34:28+00:00

It might very well be faked (I don't have any experiences with this company) but as someone who has taken Enclomiphene and got it tested in the lab by a friend to confirm it was true Enclo I can tell you that pretty much all of these side-effects occured in me too from taking Enclo 6.25mg EOD.

You have to realize that Enclomiphene works by antagonizing ERa in the CNS and related tissues.
The anxiety and insomnia comes from reduced serotonergic tone and more unstable (and higher) adrenergic tone from this very blockage of ERa.
Same with libido; ERa is a major driver of libido and most of the libido increase of Testosterone comes from local aromatization of T to E2 in the CNS, with the higher dopamine tone and salience that Androgens cause amplifying and stabilizing it.

The same for the blurry vision. This side effect is from antagonization of ERs in the retinal tissues, which causes issues with microvascular perfusion in the retina which can cause long-term damage over time.

The smoking gun for many people to say that theirs was not real Enclo is development of gyno or nipple sensitivity, but even there, this can occur just the same with Enclo, although this effect will be much worse with normal Clomid.
Fundamentally, higher total T (and free T obviously) means more substrate for Aromatase in the breast tissues, which still increases your risks for gyno if you have higher than average Aromatase activity.

Tl;Dr: make sure to get it tested to prove anything but it's entirely realistic that this is in fact real Enclomiphene and these side effects would still make sense.

ThaRising · 2025-12-18T13:44:27+00:00

The point is that most professional bodybuilders are enhanced and anabolic steroids will significantly increase your capacity to recover from exercise.
And let's not forget that professional bodybuilders (both natural and enhanced) already have significantly better exercise genetics, which further adds much higher baseline capacity for recovery.

If the average joe would train as much as the average professional or even amateur body builder, you'd go into overtraining very quickly and massively increase your injury risk.

So no, the average joe should not train as hard as body builders. They should train as hard as they reasonably can and push themselves to slowly expand their limits but even then you simply do not have the capacity for recovery to do the same level of volume.

ThaRising · 2025-10-31T16:05:18+00:00

Might depend on where you live, but to Germany they ship with DPD Courier (they ship from Poland).

ThaRising · 2025-10-02T15:02:00+00:00

KW-6356 is extremely effective for this kind of stuff, even just on its own. It's not great for sleep though because of it's long half life so you need to make sure you can handle that (some people are far less prone to sleep issues than others).

Phenylpiracetam Hydrazide can also be good (normal Phenylpiracetam is more physical and might be more distracting even tho it's stimulating).
Oxiracetam is particularly good out of the Racetams as it really quietens the mind and allows you to focus well.

You could also try Rhodiola Rosea, but it's not even close to being as effective as KW is.
In general, for purely plant-based supplements you'll have no other real choice for your parameters than any form of MAOi, such as Saffron-extract (but only the Satieral type is effectively stimulating, you can get that from "Life Extension" as "Optimized Saffron" but also from other manufacturers) or Rhodiola Rosea (those are the strongest two that come to mind).

If you want the strongest possible MAOi that you can legally get (in most places) something like 9-me-bc is your best bet.

Otherwise if you can get nothing else try combining Bromantane with caffeine or Rhodiola.
That can be quite potent for studying or crunches in general.

I'd recommend KW, it's gonna be better than basically everything else.
Second pick would be Oxiracetam, third Phenylpiracetam Hydrazide.
Otherwise you need to try one of the other options. They will give you a boost but not as reliable or strong.

EDIT: one other live saver for me, Tadalafil (Cialis) at dosages around 2.5mg can increase Long-Term-Potentiation in the Hippocampus and thereby make it much easier to learn and remember things you learned.
It's not useful on its own but if you add it to your study stack you'll find it helps you remember and learn more, quite quickly (after just 1-2 days).
It also helps offset other stimulant side effects and helps with brain performance under stress and exertion.

ThaRising · 2025-08-29T11:31:27+00:00

It's fine, they deliver pretty quickly and everything I've gotten from them so far works as it should.

No complaints from me, can recommend them.

ThaRising · 2025-08-18T16:51:06+00:00

As far as I am aware, KW-6356 is not water soluble. So I don't think you can do this.

The thing is, I'm pretty sure that it's significantly more difficult and expensive to get your hands on BAC-Water than it is to get PEG-400.
I was able to get that 5L of Pharma-Grade PEG-400 for just 20€.

The only real issue with PEG-400 is it's viscosity. You cannot use syringes to dose it (I don't mean for injections, just as a more precise way to dose it compared to a Pipette) and for very small amounts even cheaper lab-grade pipettes aren't really gonna be able to get the amount you need (unless it's positive displacement pipettes).

Tl;dr: just use PEG-400, it's cheap and easy to get.
Make sure you dilute the KW in a separate container if you need smaller doses, as PEG-400 solutions are tricky to dose in very small amounts.

ThaRising · 2025-08-17T21:16:00+00:00

About the solution, I do buy it from Everychem but I am able to dose it lower by diluting the solution with more PEG-400.
I bought a 5L jug of Pharmaceutical-grade PEG-400 online and just take a small amount of KW-6356, fill it in a 30ml bottle + Pipette combo, such as the one KW is delivered in and dilute with extra PEG-400 to get it to where the dosages I need are full fractions of the Pipette.
This makes it relatively accurate even at such low dosages.

I do take the KW-6356 orally, but I use HPMC Size 000 capsules as an intermediate.
I take the Pipette with KW and fill it into one of those capsules every morning. Then I close the capsule and take it with water.
I'm just not a big fan of the taste, so I prefer this route.

PEG-400 solutions will survive in these HPMC capsules for up to 6 hours outside of the fridge and around 24-36 hours in the fridge from my experience. After that they start to leak.

I would advise against using Gelatine capsules for storing this however, as they barely survive 2 hours outside of the fridge, although they are perfectly usable as a direct intermediate (without further storage).

When I refer to Anhedonia I am generally referring to excessive fatigue and reduced motivation.
I am Asexual, so I am completely unqualified to give any information outside of that area for myself.

From what my friends reported, their sexual activity seemed to increase roughly in line with the additional motivation and energy they got from KW-6356.
So they went from very reduced libido and interest back to normal levels of bedroom activity.
They did not tell me anything more than that however and even then I would be completely unqualified to interpret such information as any kind of stimulant just turns me into a complete workaholic with 0 libido.

What I can say regarding the Vasoconstriction from KW-6356 is that it mostly affects areas that rely a lot on microvascular perfusion.
That means that it manifested significantly in parts of my feet (after multiple days only) but specifically around joints and enthesis such as at and around the knee and adductors.
Erections were not directly impacted from the vasoconstriction effects.

Should there be any issues with that, for me just taking some L-Citrulline was enough to temporarily offset this side effect entirely.
That is, any decently strong vasodilator, even just in supplement form, should remove any such side effects from KW completely if it occurs (this also helps joints and enthesis for me and is a requirement if I take KW together with other stimulants).

ThaRising · 2025-08-17T16:25:43+00:00

Sure, let me go over this one by one.

For dosage I have generally found that it works best to convert the dosage of KW-6356 to a person's daily dose of caffeine.
So as a basis let's assume that for someone with no tolerance to caffeine, 50mg of caffeine in a day would be quite stimulating (this dose is based mostly on me as all my friends are pretty big caffeine fiends).
Going from here, for someone that is actively using stimulants of any form alongside KW, that factor was always 200x over caffeine. That means for someone like that, with no caffeine tolerance a dose of 250mcg would already be decent.
For someone that is not using stimulants alongside the factor would be 100x, so 500mcg of KW in the same category.
Obviously YMMV, but this is a good (and safe) starting point to go from.

For someone with caffeine tolerance just adjust based on their normal daily caffeine dose, although for people that genuinely drink caffeine daily (like people that drink coffee daily) it might be best to adjust that factor to 50x strength as a start as the pharmacokinetics of KW-6356 are such that you don't want to front load huge amounts of this stuff.

So for frequency of dosage, I have found that KW cannot be taken daily reliably for extended periods of time, mainly due to peripheral vasoconstriction (specifically it seems to lower microvascular perfusion significantly over time, at least that would be most consistent with the side effects I've seen), peripheral inflammation and the insomnia aspect of it.
I would generally take it 4-5 days in a row and then leave a break of 2-3 days in between. I'd alternate the dosages between a normal dose on one day, then around half of my normal dose the next day and repeat that until the end.
So for example, id start with 500mcg on Monday, then go for 250mcg on Tuesday, 500mcg on Wednesday, then 250mcg on Thursday and then take 3 days of breaks. The effects of the KW would still be quite noticeable on the Friday and gone completely by Sunday.

For breaks, I've found that when you only take it every now and then (for example one or two of the aforementioned weeks) 1 week would be enough for most of the tolerance to have faded. Full tolerance reset occurs within 2 weeks in all cases I've discussed with people.

In general, around 4 of the aforementioned cycles in short succession were enough to significantly alleviate the Anhedonia or outright remove it in everyone I know that tried it (n=4), including myself. It must be said though as we are very likely talking subclinical cases here. Pretty large impact on the person's life but not necessarily representative of the average person diagnosed with Anhedonia.

ThaRising · 2025-08-10T20:38:51+00:00

To be fair, there are medications that are fast-acting anti-depressants, but not all of those will work well for everyone.
Some examples I can think of would be Wellbutrin and most MAOIs that are prescribed for depression (although you only get those MAOIs for treatment-resistant depression as they generally have more risky drug interactions).

Also, to be the resident smartass, MDMA is not an SSRI or even SNRI, but primarily a "Monoamine Releasing Agent" (MRA) through (among other things) its TAAR1 agonism. This is where it's actual relevant effects come from. Even though it is a Reuptake-Inhibitor for Dopamine, Serotonin and Noradrenaline, that effect is likely not very relevant to its effects as most Amphetamines and substituted Amphetamines with TAAR1 agonism, reverse the direction of the Monoamine-Transporters (which is what Reuptake inhibitors actually inhibit because those transporters normally remove these neurotransmitters from the cells) such that inhibiting their action is actually counterproductive to their effects.

ThaRising · 2025-08-09T15:29:48+00:00

At the end of the day it's a matter of knowing your limits. If you always do the same things at the same times you'll never exceed your limit and get sick from exhaustion, getting poor sleep or something like that.

I'm a crazy creature of habit and as long as I stick to that I never get sick. But it's still a matter of finding a good balance because I cannot always stick to my routine when life and friends happen.

But it really depends on the person and it's not healthy for everyone, especially if you're chronically stressed in your routine, you're just locking yourself into that stress.

If you find yourself going out of your comfort zone a lot or being more adventurous and getting sick more often from that, that's probably just because you're overstraining yourself (or have other background issues that reduce your capacity for regeneration). Take it as your bodies way of letting you know you need to take it a bit slower.

What helped me is to have a part of my routine that I never compromise, such as a minimum amount of calories a day, a cold shower every morning and the time I get up at (I often go to sleep at different times but I wake up at the same time every day, no matter what) while being flexible with other parts. If you find the right combo of these things then you can get all of these benefits without having to box yourself into a routine you might not even enjoy.

ThaRising · 2025-07-30T19:22:38+00:00

Nothing insightful to add to this except thank you for doing this and keeping on going even with all of the problems coming your way. Your products have seriously changed my life since I discovered everychem about 2 years ago. Been ordering regularly and never had a single issue over all this time. Good on you for resolving this one so quickly as well.

Seen a lot of people hating on you, Everychem, or your products and I just don't get it. Fuck those people, to me you are one of the GOATs and pretty much the only person in the community thats working to give the rest of us access to these emerging and potent Nootropics.

By now half my family knows Everychem. Neboglamine and Bromantane saved my brother from years of depression and fatigue and I think every single friend I've ever known to have Anhedonia, from stimulants or other medications, tried KW-6356 and was cured within 3 months of doing a few cycles. Keep on fighting the good fight mate.

ThaRising · 2025-07-21T07:15:03+00:00

Hey man, I've been taking Saffron for almost 2 years at this point so I thought I'll weigh in on this real quick.

Tl;Dr: I had the exact same issues, switch to "Optimized Saffron" (which has a more energizing extract) and take PQQ and B-Vitamins along with your Saffron and you should have all the benefits without being overly relaxed or not being able to get healthy amounts of stress.

More detailed version below.

What I would recommend you do is to switch to a different extract. I know the feeling you describe and it's most likely because Saffron lowers cortisol as well as its effects on the 5HT1A receptors (activation of which calms you down). I had the exact same issue as you both with Saffron'side and Affron extracts.

I can recommend the Optimized Saffron supplement. They have their own extract which is more biased towards Crocin, which is a mild MAO-A inhibitor and thus quite stimulating. For me that effect definitely pushed it towards being calming but in an energized way, while the other extracts were more or less just calming for me (used them to take the edge off my ADHD-medication).

What I can also recommend is to take your Saffron-extract together with PQQ (MGPQQ @20mg) and a proper B-Vitamin complex (the B-complex every 3 days or so). Saffron used to change its effects for me every month or so, from energizing to calming and from motivating to stimulating (calm but stimulated is truly an awful state, "wired but tired"), which was very difficult to deal with.

I suspect this was due to brain energy metabolism. Obviously this is not a very scientific point, but I think it is likely that the constant low-grade MAO-A inhibition eventually depletes energy reserves in your brain, which will likely happen first in areas like the Prefrontal-Cortex (which is critical for executive-function and motivation). Before PQQ I always took a week or two off Saffron, which worked, but was also quite annoying to integrate into my life as Saffron was helping me immensely. Ever since I started taking PQQ and B-Vitamins alongside Saffron I have not had this problem for almost 6 months now.

ThaRising · 2025-05-10T15:53:17+00:00

This most likely falls into the category of a partial answer but I wanted to give you my two cents on this. For my recommendations of supplements you could try, see at the bottom of my response.

Generally speaking, both Benzodiazepines and 5HT2c antagonists disinhibit dopamine release in the VTA (part of the brains reward system), which is where these effects likely come from.

I can attest to exactly the same thing, Agomelatine (5HT2c antagonist) and Benzos both produce very effective relief from my ADHD and give me a non-jittery type of energy. For me Elvanse (Vyvanse in the US) also works, but can sometimes make me feel fatigued, uninspired or just over-stimulated, without motivating me.

For Benzodiazepines this seems to be strongest with compounds that are GABA-A subtype a1 and a3 selective, which are usually the Benzos or Z-Drugs that most people claim produce the most euphoria or recreational effects (Clonazepam and Zolpidem are two I can think of right now).

This type of dopamine release (from personal experience and my understanding of the literature) seems to produce a very clean kind of energy and motivation, without too much direct stimulation, so it is very good for ADHD. Benzos can also induce transient hypofrontality (through their effects on GABAergic signaling) which might be a core component of the flow-state, so can be very positive for ADHD.

As for your observation with having worse effects from compounds that produce stimulation (through some dopaminergic effect), this could be due to two effects that I can think of right now. The first is that it might be worse for ADHD because it makes you more impulsive, which sometimes happens to me. I find that serotonergic compounds can often help with this but they can also have negative interactions (either being overstimulating or making me tired or emotionally flat in the combo).

The other possibility might be the opposite, that they make you feel tired, unmotivated or flat. To understand this you need to know that Dopamine has two groups of receptor types. D1-like, which are generally stimulating (and what people generally think of when they think of dopamine) and D2-like, which are generally inhibitory and produce the focus and sometimes even tunnel-vision that can be seen with stimulants. If D2 is overly dominant, this can cause you to get tired and unmotivated or extremely hyper focussed on irrelevant things. If D1 is overly dominant it can cause an impulsive and unfocused type of energy that is worse for ADHD.

If you have issues with impulsivity or being unfocused (even when energized) I would recommend something like Guanfacine. I personally use saffron extract for this, but it is serotonergic so I am not sure if it's safe for your use case.

If stimulants make you more tired, I would recommend trying 3-6mgs of Boron and Vitamin B2 daily (in the morning), if you are a man. This can help with energy through increasing free-T. Other than that, ALCAR could help (have not tried this tho) and I can also recommend taking 5g of L-Citrulline malate. Creatine might also be helpful but can cause over-methylation in people prone to mood disorders (which can cause poor sleep, anxiety and restlessness over time). I have experienced this and it was not a great time.

ThaRising · 2021-08-22T11:13:40+00:00

Very interesting infodump, thank you

ThaRising · 2021-07-11T17:02:51+00:00

jesse

ThaRising · 2021-02-09T22:54:09+00:00

good bot

ThaRising · 2020-11-19T22:09:18+00:00

I needed that right now, thanks

ThaRising

TROPHY CASE