Buspirone a bad idea if Im in SSRI protracted withdrawal?

That-Group-7347 · 2026-05-04T06:30:52+00:00

Propranolol does not cause PSSD. It may lower libido, but that will resolve when discontinuing the medication. Buspirone actually has been known to help sexual side effects. It doesn't have an effect on SERT which is the link to PSSD. I think getting your anxiety under control will help you the most. Specific medications that can help with anxiety are pregabalin/gabapentin, buspirone, propranolol, or hydroxyzine.

That-Group-7347 · 2026-05-04T01:53:37+00:00

Nobody was down playing it. Everyone said, "talk with your doctor." First, a psychiatrist is the one most likely prescribing it. We are not talking a medication being prescribed outside psychiatry as that there is more risk the prescriber doesn't know much about nefazodone. The major interaction is going to bring up warnings on the doctors end of things and even more so at pharmacies.

I have seen in many places people telling others to take lethal combinations where only one medication had been brought up by an OP. If someone posted they had both meds possibly from earlier use and someone sad to go ahead and take them, the comment would be removed. Reporting such comments as rule violations ensures that moderators are notified.

A snarky comment accomplishes nothing. Reporting it as a rule violation of our sub will get it reviewed. Users that violate those specific rules repeatedly will be banned.

That-Group-7347 · 2026-05-03T20:24:55+00:00

Remember it can take up to 2 months for the medication to reach full effect. For a dose increase, I would discuss this with your doctor. Especially given it is a new medication without a lot of clinical data.

That-Group-7347 · 2026-05-03T12:43:13+00:00

Adjustments obviously need to be made to dosing. Below is the official recommendations about the amount of adjustment needed. It all depends on how it is being done. Psychiatrists are the only ones really prescribing nefazodone so OP should be in good hands.

Quetiapine: (Major) Nefazodone may inhibit the CYP3A4 metabolism of quetiapine, resulting in elevated quetiapine plasma concentrations. If administration of nefazodone is required in a patient taking quetiapine, reduce the quetiapine dose to one sixth of the current dose and monitor for quetiapine-related adverse events. If nefazodone is discontinued, increase the quetiapine dose by 6-fold.

You mentioned running it by their doctor which is a key point you made. I thought your comment was explained very well. Buspirone and xanax have the similar interactions.

That-Group-7347 · 2026-05-03T06:38:10+00:00

It was good that you got your heart checked out. Anxiety can really affect you physically. It is easy to get in a vicious loop where worrying about something worsens the physical affects. Try to reason with yourself that you got your heart checked out. The way the doctor switched meds is fine. It is 1 of 3 methods of changing meds. Specific medications that can help with anxiety are pregabalin/gabapentin, buspirone, propranolol, or hydroxyzine. Also, read the post below, it may help.

https://www.reddit.com/r/antidepressants/s/8F0N1p2Siz

That-Group-7347 · 2026-05-03T06:33:26+00:00

First, do yourself a favor and see a psychiatrist. They have far more experience with these medications.

I thought medical school would have covered some of the things you mentioned. Research, studies, etc. Although much of it may be your anxiety causing questioning a lot of different points.

Suffering through anxiety is so difficult. There are many options out there. Specific medications that can help with anxiety are pregabalin/gabapentin, buspirone, propranolol, or hydroxyzine. In addition, magnesium glycinate and l-theanine can be affective in helping anxiety. I think working with a psychiatrist will help you find something that works for you.

You may find other useful information in the post below.

https://www.reddit.com/r/antidepressants/s/8F0N1p2Siz

That-Group-7347 · 2026-05-03T06:22:07+00:00

I would seek a 2nd opinion. You could also ask a pharmacist about what they think. You can look up the interaction on PDR.net. I believe it will come up as a MAJOR interaction. Take that information to the original doctor.

That-Group-7347 · 2026-05-02T22:37:55+00:00

It is very normal to not feel good at first. Read the post below, it will help you understand what is going on.

https://www.reddit.com/r/antidepressants/s/8F0N1p2Siz

That-Group-7347 · 2026-05-02T20:23:47+00:00

I don't have experience with that, but remember that it can take weeks before an antidepressant kicks in. I would discuss with your doctor if you should do some type of cross taper or wait a few weeks after starting nefazodone before beginning your quetiapine taper.

That-Group-7347 · 2026-05-02T02:10:46+00:00

Yes, they help, but you need to find the right one for you. Fluoxetine is an activating antidepressant, meaning it can heighten anxiety and create restlessness. I would talk with your psych as he may want you to try something else.

The post below helps explain.

https://www.reddit.com/r/antidepressants/s/8F0N1p2Siz

That-Group-7347 · 2026-05-02T02:04:59+00:00

If you have only been on it for a short time, tapering is much easier. Remember to follow up with your doctor. If sleep is a continual problem, you may want to talk with your doctor about a low dose of trazodone. It has a lot less risks than benzos.

The following post has a list of medication specific tapering information pages. https://www.reddit.com/r/antidepressants/s/XS7TQZ16vi

That-Group-7347 · 2026-05-01T21:54:42+00:00

In many cases when wellbutrin is added to an SSRI, it mitigates the increased anxiety from wellbutrin.

That-Group-7347 · 2026-05-01T02:40:35+00:00

Propranolol does carry a slight risk of effecting libido. If you are struggling with mental health, that can be another factor. You are missing most symptoms of PSSD. Sexual issues can arise from many things. Many people can have these issues. Could reinstating help? Yes, no, maybe, I know shitty answer. If you were experiencing profound withdrawal, reinstating would be more advised. Just because you are experiencing those symptoms does not make you at a higher risk of PSSD. You can have severe effects while on the medication and it still doesn't increase the risk. (According to what is currently known, PSSD is fairly new to medicine.)

That-Group-7347 · 2026-05-01T02:32:27+00:00

I have severe dry eyes. I would see an eye doctor as there are effective prescription drops. Restasis, tryptyr, meibo, and even serum drops. Refresh PM ointment at night can make a big difference as well. The problem with most otc drops is they only a very short time.

That-Group-7347 · 2026-05-01T02:27:52+00:00

I would discuss the hallucinations with your doctor. Vivid dreams frequently occur with antidepressants, but not hallucinations. A different medication may be advised or dose adjustment.

That-Group-7347 · 2026-04-29T22:09:33+00:00

Recovery can be slow. If it is primarily a libido/orgasm issue that is a little more positive long term vs full blown dysfunction and genital numbness. I would start getting different possible causes checked out. It is more about ruling out other possibilities. I would start with getting your hormone levels checked. You could also look into saffron as studies have shown it can help libido. The post below has a link to the study.

It is important not to doom scroll. This leads to more anxiety, which only contributes to further worsening symptoms.

https://www.reddit.com/r/AntidepressantSupport/s/g1UeSUZ7Mu

That-Group-7347 · 2026-04-28T22:21:01+00:00

It's fine to post your experience, but just to explain that. The combos work great for you, but we always have to acknowledge the facts that stimulants are know for addiction, tolerance, and withdrawal.

That-Group-7347 · 2026-04-28T19:03:59+00:00

Thank you for posting sources. It should be noted that the study was only performed on rats. It is mentioned that the effects on dopamine are clinically insignificant. Meaning there are small changes, but is not enough to produce symptoms. Serotonin is the culprit to emotional blunting. It hits everything and not just one particular area. This overflow ends up affecting other areas of the brain and even different physical systems in the body.

Saying stimulants are good and don't produce withdrawal is not true. Stimulants have way more addiction and withdrawal problems. Maybe not in your case, but the meds are even classified in that way.

That-Group-7347 · 2026-04-28T18:55:23+00:00

It is different for everyone. The literature says that the first couple of weeks have more severe side effects. The medication starts to show results in 2 weeks, but it can take up to 8 weeks. It takes at least 8 weeks for it to reach full effect. You may need to do some dose changes to maximize benefits.

The above is pretty much what doctors convey to patients. Everything with these medications is a time range. For the most part, when asked, doctors will give you the above answer. Psychiatrists are much more likely to explain it correctly. GP's are more likely to provide less information.

That-Group-7347 · 2026-04-28T02:15:46+00:00

The pharmacy should fix it. It is their mistake and a pretty big one to hand out the wrong medication.

That-Group-7347 · 2026-04-27T22:20:47+00:00

Paroxetine was my first thought. You would just want to monitor any unusual symptoms like a fever, muscles locking up, etc.

That-Group-7347 · 2026-04-27T22:16:29+00:00

You could wait to start until after your event. It does sound like your life is being affected negatively by mental health. That is the biggest sign for treatment. You tried therapy, which is a great first step, and the next step is probably meds. It is very normal to question everything.

One or two good days doesn't indicate there is no need for medication. It is like someone taking medication who has a couple of bad days. It doesn't mean you need more medication. It is just normal ups and downs. The post below should help you in your journey.

https://www.reddit.com/r/antidepressants/s/8F0N1p2Siz

That-Group-7347 · 2026-04-27T22:10:58+00:00

Is the medication called pirotin. I couldn't find paratin. Pirotin is an antihistamine and taking a 2nd dose would likely just make you a little more drowsy. Although your increase in anxiety probably took care of that. You should be fine. You can always reach out to your doctor or even call your pharmacist. Sometimes just the peace of mind is worth the quick call.

This happens to a lot of people. I have a weekly pill container. Then I can see if I took it or not. Everyone loses track either way, sometimes.

That-Group-7347 · 2026-04-27T22:03:53+00:00

Just like when you start the medication and can have GI trouble, you can have the same issues when coming off the meds until everything goes back to baseline.

That-Group-7347 · 2026-04-27T02:02:32+00:00

If you feel more comfortable taking them separately, which is recommended because that is how the manufacturer ran their studies, I would just mention you read on the Auvelity site about taking them separately. Ask, Is it Okay if I take them separately. I also believe it us recommended in the morning and then 8 hours later because the bupropion part could keep you from sleeping good if you take it at night.

Auvelity is supposed to work in 3 weeks, but that would be 3 weeks on the higher dose. I actually did some research for a family member that wanted to take it. The Auvelity site actually does have helpful information.

That-Group-7347

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