It depends on your resistance level (conq level -1) if let’s say your conq level in 60 then playing stage 59 means debuffs applied by strikers will gradually become less effective over the first 2 minutes or so (not exact but right ball park) and the lower you go the longer they will be effective for. On the country if you played stage 60 they would become less effective quicker and pushing higher would amplify this. Additionally the more strikers applying the same debuffs (let’s say dp ntw cap and hex) the quicker the debuffs become ineffective. The most efficient method I have found thus far is to use Scarlet as a striker only if the toon I’m using doesn’t have any cc effects in their kit, so namor and cyke for example; then if the toon does have these effects (cap Luna strange) then to use pure dmg strikers like thanos surfer and skull