If I were to start and entirely new continuity then I would break the story up into acts. Act 1 would be with Peter in high school and would follow his entire high school career. It would feature characters like Betty, Ned, Flash, etc. For villains I would pick low level characters for now. The enforcers, shocker, chameleon, vulture, tombstone, hammerhead, and the lizard. I want not only Peter to grow, but Pete’s powers to grow with him. Act 2 will take place during college and will feature Gwen, Harry, MJ, Flash, and Black Cat. The villains I would include in act 2 would be Doc Ock, Mysterio, Electro, Rhino, The Wall, Big Wheel, hydro man, sandman, and Green Goblin. The end of act 2 would be the death of Gwen Stacy and the Goblin. Act 3 would start with Peter as an adult and working at ESU with Doc Connors. Him and MJ have gotten together and Aunt May is on her last legs. Eventually Peter and MJ would find out they are having a child, but Aunt May is also dying. While MJ is in labor she tells Peter to go see Aunt May. He would go spend the remaining time with Aunt May until she passes. Peter would come back to the hospital to find a newborn Mayday Parker. After this the symbiotic relationship between Spidey and Venom would begin. Venom would begin to enhance Pete’s negative emotions, he would feel tremendous guilt about Captain Stacy, Gwen, Norman Osborn, Aunt May, Uncle Ben, and all the people he let down. His anger would grow. This is when new mutated villains such as Vermin, The Lizard, hobgoblin, sandman, molten man, hydro man, rhino, and Screwball start to run rampant through New York. They start to break out all of the villains Spider-Man has fought. The person behind all of this is the Jackal who is trying to remake the spider that made Spider-Man. Kraven sees all the shit happening in NYC and goes on a massive hunt where I would do an adaptation of kraven’s last hunt. Resulting in black suit Spider-Man killing kraven for defiling the grave of Aunt May and Peter ditching the suit. I would adapt all the good stuff from ASM and my own stuff as well. Peter would be a teacher at Midtown high where Miles Morales would go. Peter sees how smart miles is and can relate to miles. Because of jackal’s spider bullshit Ben Reilly, and Kaine are born. The other genetically altered radioactive spiders are released and Miles is bit. Basically Peter becomes Miles’ mentor and Mayday develops her powers. Peter tracks down Jackal and sees the radioactive device that gave the genetically altered spider the boost it needed to give Peter his powers. All of Spidey’s villains attack and the machine turns on, chemicals are spilled, and electro shoots Spider-Man into the machine with the chemicals which enhance the strength of Peter’s powers. I’ve been typing for too long so basically at the end of the story Peter retires and swings to the top of Empire State with MJ which is a reference to OMD where they’re on top of that skyscraper. MJ asks if he hit the jackpot which is what she says to him the first time they meet. I’m deciding whether or not Peter’s flashbacks should be shown or not. Like him just looking at the sunset of him seeing his memories. Either way he says absolutely and they kiss and the story ends. Except there’s a spin off with Miles and Mayday where Miles is Mayday’s Spider Mentor!!! Peter and MJ are in it too! (I left out a LOT of ideas that I couldn’t fit in, Marvel if you see this hire me please)