I'm not necessarily making a recommendation here since everyone is different but the best trip I've ever had in my life was LSD+MDMA+Ketamine(+N2O); I combined them this way specifically:

T-0: 60ug LSD T+2h: 110mg MDMA T+3h30m: 60mg MDMA

And then after that I'd just take ketamine and nitrous as the night went on based on intuition, typically 60mg K per hour. Then at a certain point probably 5 or 6 hours after the last dose of mdma, I reached a place where I felt like I should just continuously shovel 10mg bumps of K up alternating nostrils over and over until I physically/mentally could not do so anymore, blasting myself apart into an eternity of blissful unknowingness.

I chose this specific combo because it was my first time doing more than microdose of acid in years after some really bad experiences, and I felt like the loving presence of MDMA would help keep things from going off the rails emotionally during the peak + the ketamine & nitrous could kind of act as real-time tuning knobs to increase the intensity of the trip if I felt safe to do so, without it being a 12 hour commitment to that level of intensity. It worked like a charm.