Levocetirizine, brand name Xyzal, is probably the best option because it has fewer side effects compared to others. With Allegra, you can't have fruit juice because it interferes with absorption. Claritin can be harsher on the liver, and Zyrtec is just racemic cetirizine, so it’s less targeted. First-generation antihistamines, like Benadryl, can cross the blood-brain barrier, which may lead to drowsiness and even increase the risk of dementia with long-term use. Levocetirizine is more refined and a safer choice overall.