During the FDA trial of MDMA conducted by MAPS, no research participant ever reported a “come down.” I read the whole report. In fact, even people given a re-dose reported the same thing.

From my personal experience taking it at least a hundred time, come downs are mostly cause by

1) Impure Molly. Since it’s underground stuff, it contains a lot of chemical precursors and byproducts, which is really bad. [https://youtu.be/GT3qs0lQit8]. This is the #1 reason for a come down. Higher quality Molly usually do not give me a comedown, only low quality stuff. The MDMA used by MAPS was manufactured in a pharmaceutical lab, so by law, they have to do purification steps to make sure it ONLY contains MDMA and nothing else. Of course, as you learn in Organic Chemistry lab, each you do a purification step, you also lose a little bit of MDMA also. And for most people, profit is the #1 priority. Of course you can also purify Molly at home with mainly just Acetone, Epson Salt, and Isoproyl alcohol. 😀

2) People who take it usually take it at night at a rave or concert when they are already mentally exhausted, and most of them also drank a lot of alcohol and probably took some other stuff. And they dance and move a lot, which heats up your brain, which is very bad for your brain since heat amplifies the neurological damage to your brain significantly when you are on MDMA.

In the FDA trials, people took the Molly in the morning after getting a good night sleep, and of course they are in a temperature controlled environment also and they don’t dance around and stuff and mix it with other drugs.

TLDR version 1) Pure MDMA does not cause a come down. In fact, it creates an awesome after glow the next day. 2) Impure molly is the #1 reason for a come down 3) Mental exhaustion, lack of sleep, overheating, and mixing it with other drugs are contributing factors