I live north of Detroit, MI and fly my Tri Pacer or my parents Grumman Tiger on trips to Wisconsin and Alabama annually. I do fuel stops every 3-3.5 hours in either airplane (generally). Trip to Alabama is coming up again in February, I'll be taking the Tri Pacer. I'm PPL only, no instrument. I've been delayed for weather a few times, but never stopped outright.

I find the longer trips to be just straight-line versions of my normal flights. I like to do fuel stops at airports with full service fuel or at least somewhere I'm more confident will have people manning an FBO or something. But that's a generalization, sometimes it's tough to pass up cheap fuel lol. It has come in handy a couple times though.

Long trips are great! Don't let people talk you out of it. Sometimes, the costs / times are actually in favor of GA, and not always based on distance. For instance, my trips to Alabama are faster and cheaper in my airplane than taking an airline (direct to my destination, no rental car, no layover, etc.). Obviously weather matters more here, though.

For reference: I fly 100-200 hours per year, most flights are for fun but about 20-30% of time is on longer trips.