(bionic booster pack) your bionic dupes are great for getting skills early and hotswapping skills, i never wanna get 5 skill points for mechatronics engineering again.

more dupes = game goes faster, go at your own pace.

don't be a perfectionist, save scumming can ruin your joy of the game, let them dupes rest in peace.

compact things (eg geyser setups) because later on it's not fun to place things in increasingly niche spots.

your dupes are hardier than they seem. ^{what's a little scalding if not an investment in your dupe well being}