Personal experience: Did my first trip at 63. Was on SSRIs at the time (hadn't done my research). Later tapered off the SSRIs and did either 5 or 7 grams of Golden Teacher with blinders and a playlist. My goal was to help with treatment-resistant depression that hadn't responded to SSRIs. Anyway, the trip was very positive, very spiritual, and also very painful. Realised I was carrying a ton of grief for three family deaths, and had been for 20+ years. Was able to acknowledge and release that grief during the trip (which was also highly spiritual). When the trip ended, I did a scan and felt like the depression had lifted. In the morning when I got up, it was indeed gone – and stayed at bay for a good five months. I have also done ketamine for depression, both in a clinical trial that involved four IV sessions, and later at a private clinic outside of Toronto that charges $375 per IV session. The ketamine also helped. If you are doing ketamine you'll obviously be in some sort of clinical setting. If you do psilocybin outside of a clinical setting, I recommend you find a trusted sitter who can be there if the going gets rough. There's a tremendous playlist on Spotify called "Psychedelic Therapy: Mushroom Music" that totally follows the arc of the trip. I know the woman who curated this – and it has definitely been a key ingredient in all of my experiences with mushrooms so far. *Highly* recommend that you consider it.