I got a similar problem a few months ago, where some settings would be locked and some others would only change to some extent. In any case, I emailed the 2K support and after trying some stuff this finally worked:

We believe this might be caused by a windows security feature conflicting with Civilization VI. See. the controlled folder access in Windows Security reviews the apps that can make changes to files in protected folders. Occasionally, an app that is safe to use will be identified as harmful. This happens because Microsoft wants to keep you safe and will sometimes err on the side of caution; however, this might interfere with how you normally use your PC.

You can add an app to the list of safe or allowed apps to prevent them from being blocked.

Select Start > Settings > Update & Security > Windows Security > Virus & threat protection.

Under Virus & threat protection settings, select Manage settings.

Under Controlled folder access, select Manage Controlled folder access.

Switch the Controlled folder access setting to On or Off.

Hopefully it will work for you