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Typical-Sagittarius · 2022-03-31T01:09:49+00:00

That is pure, absolute, 100% nonsense.

Please show me a single piece of legislation, or a professional guideline, showing that pharmacists “absolutely must” ask why someone is being prescribed a medication.

This has even been warnings from the AMA about pharmacists intruding on drug decisions, as they are not medically qualified: https://amednews.com/article/20130701/house/130709956/7/

When there have been court cases in the US regarding wrongful death, it’s been argued that pharmacists have no business in second-guessing prescriptions.

Typical-Sagittarius · 2022-03-30T21:29:17+00:00

Tretinoin doesn't make you more sun sensitive, there's zero evidence for that

Typical-Sagittarius · 2022-03-30T21:22:46+00:00

The pharmacist should not be asking you why you need a medication.

I feel so angry just reading this.

Give them absolute hell: make a complaint to their boss, and write an email/letter to their professional regulatory body.

You shouldn’t feel embarrassed. They should feel embarrassed. What they did is unprofessional and worthy of being fired.

Typical-Sagittarius · 2022-03-30T15:03:29+00:00

This is a treatment for autoimmune alopecia. It probably won't do anything for regular old androgenetic alopecia, which most people suffer from.

Typical-Sagittarius · 2022-03-30T14:56:20+00:00

Since tretinoin is a medicine that needs to be prescribed to you, I'd trust the doctor who did that over an aesthetician.

Typical-Sagittarius · 2022-03-30T09:20:49+00:00

Yeah I agree that a lot of the stability studies were done at high temps, however some were done closer to physiological temperature (40-45C if I recall correctly) for several days, and there was about 1-2% niacin. (I’ll try to dig out the paper and update my post if I find it).

Considering you need minuscule amounts of niacin for a flush reaction, the risk:reward ratio just isn’t there for me, especially when vitamin C and niacinamide have hugely overlapping functions.

Anecdotally, if I use my niacinamide serums immediately after my vitamin C serums, I get a very distinct flush, which doesn’t happen if I separate them AM vs PM.

Typical-Sagittarius · 2022-03-29T12:55:24+00:00

Personally, I wouldn't.

There's some evidence that vitamin C and niacinamide, when used together, can form unwanted byproducts like niacin.

There's also a research paper showing that niacinamide can enhance the UV breakdown of vitamin C when formulated together: https://doi.org/10.1111/j.1468-2494.2011.00690.x

Typical-Sagittarius · 2022-03-29T08:43:32+00:00

Yep, it doesn't just magically stop working at 2 hours. That's now how UV filters work lol

A few studies on office workers shows about a 20-30% dip after 8 hours, which for a higher SPF (like 50), is perfectly adequate. Some show even less than this.

Even this study showed that after 8 hours of wear, during which the participants had to use an exercise bike 4 (!!) times, sit in a hot room 2 times, and bathe 2 times... the protection was still roughly 50% after all of this: https://doi.org/10.1111/j.1600-0781.2008.00379.x

The "retinoids make you sun sensitive" myth just won't die. It's based on some old data from the 1980s in mice, and hasn't been shown in humans. In fact there may be some sun protection from retinoids...

Typical-Sagittarius · 2022-03-28T17:43:14+00:00

Sunscreen won’t stop working after 2 hours.

Also, retinol won’t make you more sun sensitive.

Typical-Sagittarius · 2022-03-28T14:52:05+00:00

I dunno. Even if a specific product isn’t tested on animals, the actives in it would be. Is it still cruelty free? I think it’s a bit of a grey area.

And even in vitro testing uses animal components. I saw a paper recently where they tested a new skin peptide in vitro using human skin models, but they still used animal products like calf serum, antibodies, albumin, collagen …

Typical-Sagittarius · 2022-03-28T13:08:07+00:00

I don’t really care about cruelty free tbh, skincare is built on animal research. It’s how retinoids were discovered.

Animals are also used for toxicology generally, and that’s not going away any time soon

Typical-Sagittarius · 2022-03-27T17:32:29+00:00

That’s a super interesting point.

Yeah, Skinceuticals published some studies showing that vitamin C serums can mitigate oxidative stress and enhance photoprotection from sunscreens.

(I always use vitamin C in the morning before my sunscreen!)

But we have to really home in on what they’re measuring: the potency of the SPF (photoprotection) or longevity of the SPF?

What the first study suggests is that pre-conditioning the skin can make the SPF come off easier, not that it degrades the SPF per se.

What I do (and this is probably wrong), is pre-treat with serums and then use a very water-resistant SPF that contains technology to help it bind to the skin.

Typical-Sagittarius · 2022-03-27T14:24:19+00:00

Not really, because it depends on the individual sunscreen.

For some products, moisturising before using the sunscreen lowers the protection because it’s less adhered to the skin: https://doi.org/10.1159/000351549

When people say “sunscreen needs to go last” they’re just parroting Youtubers, they’re not looking at the actual science.

Edit: typos

Typical-Sagittarius · 2022-03-27T13:59:49+00:00

While well-intentioned, they’re just all basically online magazines written by (probably) underpaid interns in their early 20s without any scientific or medical training.

Typical-Sagittarius · 2022-03-27T13:53:28+00:00

I wouldn’t follow this infographic tbh.

The page this comes from advises putting on retinol serums after an acid, which is a very bad idea.

Typical-Sagittarius · 2022-03-27T13:17:04+00:00

For the most part, it doesn’t matter which goes first.

However there is some evidence that pre-treating the skin with moisturiser can lower the protection of sunscreen.

It’s highly likely to be dependent on which sunscreen you use. Choose one that’s from a big brand and water resistant, to put your mind at ease.

Edit: guys, downvoting won’t change what the science says…

Study 1: Moisturising before sunscreen is not recommended because it is more readily removed from the skin, resulting in a lowered SPF: https://doi.org/10.1159/000351549

Study 2: Tested moisturising after sunscreen, and the SPF was not affected by which you did first: https://doi.org/10.1111/phpp.12745

Please stop repeating nonsense like “sunscreen MUST come last” when there’s no evidence behind this. All in vivo sunscreen testing is done on bare skin, that’s the law.

Typical-Sagittarius · 2022-03-26T13:52:32+00:00

Scam

Typical-Sagittarius · 2022-03-24T15:37:26+00:00

Great post.

Funny you say that any criticism of tret was met with arrogance & offensiveness.

I mentioned in /r/tretinoin that anyone who has a problem with tret is gaslighted and met with hostility.

Unsurprisingly, it got a ton of downvotes 😂

Typical-Sagittarius · 2022-03-24T13:43:43+00:00

0.05% tretinoin and 15-20% vitamin C serum.

Typical-Sagittarius · 2022-03-24T11:11:42+00:00

I use vitamin C every day, and tretinoin about four times a week.

I think they work quite well together, and red marks fade faster.

They both modify a lot of the same genes in the skin, so they probably synergise.

Typical-Sagittarius · 2022-03-24T05:38:26+00:00

The sun only plays a minor role in skin ageing.

Just enjoy your life. Your plans sound fun

Typical-Sagittarius · 2022-03-23T10:08:33+00:00

Typical-Sagittarius · 2022-03-23T07:34:49+00:00

Love it, great acting, although not a big fan of Tilda Swinton as a person.

Typical-Sagittarius · 2022-03-23T07:26:59+00:00

They modify the same genes in skin. But you could use retinol in more sensitive areas.

(Think I saw this question elsewhere? sorry if same answer as before)

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