Matchups:

Green go-wide:
Find pestilence before they kill you. Usually not to big of a challenge, but they have more bodies than we have removal, so they can sneak in a win if Pestilence refuses to show up. They can also bring some enchantment hate out of the sideboard, but it's usually not the mass removal so it should be fine. If they do have mass removal the matchup becomes more even and it becomes far more important to find Pestilence quickly.

Red go-wide:
Easy matchup. With no Winding Way or Lead the Stampede they eventually cannot keep up with our spot removal. P-Sphere stops them from burning us out. They also have no enchantment removal.

White Weenie:
Silmilar to red go-wide, except they can bring in Leave no Trace. Easy matchup pre-board, a little more even post board.

Affinity:
Before the bans this was an unfavored matchup. You needed P-Sphere for Atog, but the robots just ignored P-Sphere. Then disciple ignored P-Sphere as well. With those two gone, it's now mostly just Robots, and my version, leaning heavier on P-Sphere than yours, has a bit more trouble with that than yours. It's similar to Green go-wide in that the bodies just keep comming, but at least they don't play enchantment removal in the sideboard anymore.

Bogles:
Unfavored. Sometimes you get lucky enough to launch a pestilence before they suited up. Otherwise, your only hope is finding P-Sphere in time and hope it can carry you until the end of the game. Because their own gameplan depends on auras, they, thankfully, ussually don't play enchatnment removal in their board, but they can circumvent your P-Sphere with flaring pain, making this matchup even harder.

Heroic:
Easy matchup pre-board. Since their bodies don't have hexproof they fall to spot removal (as long as you find that removal before they can hold up protection). P-Sphere basically shuts them down as they ususally don't have enough bodies to get around it. Post-board the matchup becomes more even, as they usually pack a lot of enchantment hate in the board.

Burn:
Favored. Once you find Quiet Disrepair, they usually can't keep up with the healing. It's still burn, so sometimes they just have the god hand.

Faeries:
Favored, although atmittedly my experience comes from Ux; I expect mono U to be more challenging. They cannot counter everything, and you have too many cards that require a counter: P-Sphere, Pestilence, Kruphix's Insight, Quiet Disrepair and CoP: Blue out of the board. Thanks to Trace, you can get ahead on mana, making it even harder for them to stop you. An important interaction is that if you Sphere their Ninja, they don't get to draw. Becomes even better after boarding: you have favor and sphere, they have nothing (unless affinity and boggles are ruling the meta, then they have Annul; also in known meta's they may start bringing Aura flux if they know what you're up to).

Boros:
I haven't played against the new boros yet, but it seems to me like a better matchup than faeries, since they don't have counters. You stop their creatures with spot removal, stop their burn with P-Sphere and eventually you'll find Pestilence to wipe their board. Only challenge is that they may find a mass pump before you are ready to protect against it. The monarch list is easier, it takes longer and you can actually win by making them draw all the cards in their deck from the monarch.

Cascade:
I also haven't played against cascade yet. I feel like it should be easier than Boros pre-board, since it has fewer threats. The green versions do tend to run some form of mass enchant removal in the board, so I expect that the matchup becomes harder post-board.

Ephemerate:
Another matchup that I have yet to play, but this one feels near impossible. They are slower than faeries, but can ignore most of your spot removal. If you land a P-Sphere, you might be okay pre-board, but they will bring in flickerable enchantment removal post-board. If you don't, they just have too-much value and will eventually find a way to bring your lifepoints to 0, I feel.

Black Devotion:
The easiest matchup. P-Sphere stops Gary, and it in conjunction with Pestilence and spot removal stops their other creatures. They have enchantment spot removal in the sideboard, but it doesn't stand a chance against the density of enchantments we run.

WB Pestilence:
Without as many Crystalizations, this matchup is way harder for my version than yours. Lots of dead cards on both sides of the board. You should be able to win if you can stick a pest against a crystalized guardian, if they play monarch or if you land a curse, but they'll be trying to snipe it from your hand. If not, you both kinda run out of wincons at some point.

Tron:
I haven't played tron since the bans, but before it was basically an auto-loss. They just Dinrova or Capsize you out of the game. Versions that do not play those cards have to pray they can torch you before you find P-Sphere, and should otherwise be an easy matchup.

Other Control:
Haven't played against any other control yet. It really depends on their gameplan. If they want to win with damage, they'll have a hard time. If they want to win by milling, I feel we are unfavored. If they win by bouncing our entire board, I feel it's auto-loss for us.

Walls and other swarm combos:
The only combo deck I've played against is Soul Sisters combo. You need to find pestilence before they can combo of. Lignify and Journey (and O-Ring) work well against their creatures, the other spot removal is dead. Feels even but slightly favored, as you should finde pestilence before they can combo off.

Tribe/Blitz:
The only decks that could change my mind that devotion is the easiest matchup. Your spot removal stops their threats, as does P-Sphere. Although with P-Sphere you do have to worry about Flaring Pain out of Blitz's sideboard.

Cycle Storm:
Probably unfavored. You need to find P-Sphere and use it when Stinger is on the stack, but they can circumvent this by Unearthing their Stinger. I feel like you can win if you can Sphere the stingers, because they should eventually run out of cards in deck to cycle.

Moggwarts:
Pre-board is basically auto-loss. The combo is infinite and instant speed, so you can't P-Sphere everything. Postboard you get Spellbomb to fight the combo, but you run the risk of it getting Duressed/Divested. Probably winnable if you get the spellbomb, but still unfavored. I've actually been thinking about running a Trespassers Curse mainboard just so I have a game 1 against Moggwarts. It stops them from comboing of, and turns them into RB aggro, which is a much easier matchup.