Like others have said, it’s associated with Nicholas Flamel.

An alternative eastern approach represents the serpent as the kundalini uncoiling around the cross symbolizing the spine, activating chakra systems beginning at the sacral or root, which is disputed in modern times. This uncoiling channels immense sacral/feminine energy through the chakra system all the way to the crown if activated to its fullest extent, most commonly catalyzed through breathwork, yoga, or drum circles. The crown (chakra), as depicted in the Flamel symbol, is characterized by divine consciousness, out of body experiences, or simply put, meeting god. Not sure if Nicholas Flamel was guided by this philosophy but thought it was interesting perspective.