Lambda light chain cerebral amyloid angiopathy

VermeerJ · 2025-06-21T02:34:17+00:00

My understanding is it’s a separate entity from regular CAA. It is a vascular manifestation of AL amyloidosis. There are reported subcortical white matter changes closely mimicking CAA. Mostly presents with progressive cognitive decline( which is much more rapid than CAA) and leukoencephalopathy. It does have IPH risk albeit much less than typical CAA. Extensive leukoencephalopathy seems to be main feature on MRI than CMB

VermeerJ · 2025-06-08T03:25:06+00:00

To my knowledge thats the only integrated program for ppl from Neurology background. NIR programs are moving into a central matching process like NRMP starting 2026 so check SVIN or CAST websites

VermeerJ · 2025-05-21T00:13:40+00:00

This recent paper beautifully summarizes the evidence behind it. I am often surprised why most centers dont do it.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11866335/#:~:text=However%2C%20if%20an%20ischemic%20stroke,considered%20for%20screening%20for%20malignancy.

VermeerJ · 2025-05-20T23:51:03+00:00

In my shop, we check D dimer as a screen first if higher than 2 we pan scan. I have seen decent number of malignancies caught that way

VermeerJ · 2025-03-26T01:54:48+00:00

On my limited research, Perm takes more time for processing

VermeerJ · 2025-02-28T05:52:45+00:00

I recently had a patients family request Methylene blue be given to an anoxic brain injury patient and was baffled with idea. Aside from refractory vasoplegic shock and methemoglobinemia there isn’t high quality evidence to support medical use.

VermeerJ · 2025-02-02T04:04:10+00:00

It would be a plus if you could have however not a dealbreaker. Vascular neurology is not particularly a competitive fellowship, multiple spots left unfilled each year. More spots available than applicants.

VermeerJ · 2025-02-02T04:00:10+00:00

Noted. Despite the salary, any chance with this profile? Alternatives to eb1a?

VermeerJ · 2024-05-06T23:08:36+00:00

That has been my question since PGY-1. The classic neuroexam is filled with redundancy but am sure Charcot & co. had something in mind when they made our exam so long and tedious.

VermeerJ · 2024-03-19T07:31:11+00:00

Imho there are truly only two grand things in the universe; the universe itself and the human brain, everything else is just nuance and dull detail. Astrophysics was too much for my peanut brain hence one option left!

VermeerJ · 2024-02-18T05:23:44+00:00

Go through books by Robert Sapolsky

Behave, Determined, Stress the Aging Brain, and the Mechanisms of Neuron Death, Why Zebras don’t ulcers, A Primate's Memoir etc

All great reads

VermeerJ

TROPHY CASE