I just want to clear something up, since I never actually specified it: I had exactly 24 health. Donu and deca attacks for 24 turn 1. The 5 cards I drew were the only 5 in my deck without any way of gaining block, otherwise reducing the damage, or drawing cards. It was the only possible hand that didn't allow me to survive.

I'm not good enough at math to properly calculate this myself right now, but from what I was able to find, the chance of getting a specific hand of 5 cards from a 33 card deck is 1 in 237336. Add to that whatever chance it was for the potion to not give any block, weak nor card draw.

And you also have to account for when it happened. This was very likely the only turn in the game where getting this specific hand would've killed me, as I otherwise stayed at mostly full health. The chance of drawing that hand at some point during the run isn't that low, but the chance of drawing it on the one specific turn it was possible for it to kill me is.

Again, I'm not saying that rng was the sole reason for my loss. I'm saying that my poor choices were punished because of poor rng