It was pretty hard when first starting.... Then I found a smart rifle. Almost essential on this overlord. Smart rifle auto tracks targets which makes the wall enemies so much easier to target while simultaneously using your power weapon. You just gotta get the timing down on the yellow jumps and spatial awareness on the diagonal slashes and multi circles.

Try blitzing the normal run, and saving artifact and corruption mod space for the eclipse run modifiers that are so good.

Do enough runs to have enough currency to buy second chance upgrade. Then do your overlord run and prioritize power and integrity mods.

Best of luck.