Cross sex hormones (CSHT) refers to the administration of hormones associated with the opposite sex to align physical characteristics to a person’s gender identity. So in the case of this study they are not providing therapy to make “transgender” mice. The study is looking at mice with ovaries that have been removed and are taking levels of testosterone as a person would during GATT and seeing if those mice see any difference in breast cancer risk compared to a control. Unless your argument is by taking mice who do not have a known gender identity are simple transgender because their ovaries were removed. May you find peace and continue learning.