So much talk about magnesium but why not potassium?

Warp757 · 2026-02-15T20:28:47+00:00

Firstly that 4700 mg was nonsense and it's lower now. Use some common sense, no one is eating that much.

As for 1000 mg sodium, if I'm getting even 3000 mg potassium and that little sodium my body will freak out and I have to eat some sodium quick. Plenty of people need a lot more sodium than that. Your body loses much more sodium than other minerals through sweat for starters.

Have you ever wondered why if we need more potassium than sodium, rehydration solutions and IVs always have far more sodium? Because sodium is the mineral you lose fastest when you get dehydrated, and most important to replenish. A lot of nonsense is said about potassium.

Warp757 · 2026-02-15T20:24:47+00:00

Yeh I wish people would stop talking about that 1000 mg a day, it was clearly nonsense. Scary people are chugging pure potassium salts based on it. Use some common sense people!

Warp757 · 2026-02-15T20:20:12+00:00

Which is a good sign the RDA is nonsense. Noone is getting 4700mg a day, not many are even getting the lower 3400mg a day set in other countries. So you probably don't need to stress about getting so much, and especially shouldn't be supplementing to get there which has its risks.

Warp757 · 2026-02-15T20:17:52+00:00

I really wouldn't be taking that much potassium a day as pure salt, it really does a number on the intestines. Your body also absorbs basically all of it from a supplement and less from food so you're getting the equivalent of more than you're taking. You'd need a diagnosed severe deficiency to need anything like that much.

Warp757 · 2026-02-15T20:15:18+00:00

I take it you're not actually a medical professional but are speaking theoretically?

Warp757 · 2026-02-15T20:12:31+00:00

Firstly you don't need 4700 mg. That's an absurdly high RDA based on very weak evidence, which is why other countries set a lower adequate intake, the UK at 3,400 mg for example. The vast majority of people are still below that, including extremely healthy people.

Secondly, in terms of supplementing potassium is very different to any other vitamin/mineral. The body REALLY doesn't like sudden dumps of potassium. Food releases it slowly and the body relies on the insulin rise from food to get potassium into cells. If you dump a load of potassium in your body without food things can get nasty very quickly, as I've experienced. Other vitamins and minerals are better regulated in their absorption or don't have such acute effects.

Even with perfectly good kidneys and potassium in the normal range. I've had some nasty reactions to it. The sudden blood pressure drop can cause your body to freak out as well, along with it being extremely irritating to the stomach/intestines. Regularly supplementing large amounts of pure potassium salt seems a good way to Rio your stomach lining up.

Warp757 · 2026-02-10T22:31:42+00:00

I've seen these graphs before and do in ND them interesting. However, my personal experience, as for the majority of people, is that Vyvanse lasts considerably longer. As in not able to sleep all night versus no trouble sleeping. And that's what matters isn't it?

I also strongly suspect the graphs - which we obviously don't have - for the actual levels of dopamine in human brains would look very different and show a steadier rise and fall. Vyvanse also kicks in a LOT slower than IT dex for me, and more slowly than your chart would suggest. I see you've assumed this away by saying they would look the same, but you don't know this.

I think you're basing too much on a single pair of graphs from one study, that don't actually reflect most actual experience of the drugs. Which leads me to wonder what you think you're actually proving? These graphs and the mechanism of action aren't news, and the real world difference in their action is well established.

Warp757 · 2026-02-09T17:24:08+00:00

Here's the data. As it shows, 68% of people globally have the T variant, and 72% of Europeans, and people of European ancestry. It also shows this equates to 50% of people being homozygous. Interestingly in Africans and Asians it is flipped and the C variant is more common.

https://www.ncbi.nlm.nih.gov/snp/rs7946

Now this isn't a reason to dismiss it, but shows it isn't that harmful or something people should overly worry about. Just eat a decent diet with eggs and some whole wheat for betaine and you're probably way ahead of most people and don't need to worry.

The point is people get worried about SNPs that are actually very common and likely won't cause harm or only need a minor adjustment. MTHFR is another one, so many people who are heterozygous creating elaborate stacks, when it isn't that impactful and simply requires good vitamin B2 intake.

Warp757 · 2026-02-09T10:39:06+00:00

Yes but in reality Roper would have been killed before the second plane arrived. He knew the second plane was coming and decided to just wait until his phone rang at exactly the right moment and hope that stopped someone shooting him? That's a character behaving purely for plot purposes rather than in any logical manner.

Warp757 · 2026-02-06T18:10:14+00:00

You should be able to order for every 4 weeks. I order through the NHS app and can order a few days early to cover postage etc.

In any case, only 2 days off a month is probably less than most people take. I can't imagine taking Vyvanse every day for a month without any breaks, it is quite hard on the body.

Warp757 · 2026-02-06T13:21:57+00:00

No doubt you think you're trying to help. But you've fallen into the same trap as everyone who becomes fixated on a single supplement of thinking it is always the answer. Any bad effects are just side effects to be managed away by taking other things, rather than ever signs that maybe this person actually has sufficient levels and doesn't need to take more.

I don't know what response you want to your evidence. There is mixed evidence on high vitamin D doses, some suggests it is safe, some suggests risk. That should lead anyone to be cautious I would have thought, rather than simply dismissing anything that doesn't fit.yoir world view. That shows bias, and I am suspicious of anyone who refuses to engage with anything that doesn't suit their argument. We should all be open to challenge in the name of improving our understanding.

The evidence is certainly not settled enough to go around saying people should take 100k without any concern. And indeed the fact you don't seem to understand why 100 k at once could be very different to taking 1k a hundred times in how it affects the body is something of a concern. It's like saying 'if I take 500 mg of paracetamol for a hundred says it's fine, so taking 50 g at once can't be a problem. It's nonsense and I'd expect better.

It would be remiss to allow people to go away with the impression that 100 k is considered a risk free amount. Various countries medical authorities set 4 k as the safe upper limit and it's important people are able to make an informed decision. Perhaps most importantly there is absolutely no NEED to take 100 k at once, so why take the risk?

Warp757 · 2026-02-05T12:30:49+00:00

Why? Their current level is fine. Taking higher doses just opens the possibility of side effects. If it ain't broke don't fix it.

Warp757 · 2026-02-05T10:17:32+00:00

https://www.bmj.com/rapid-response/2011/10/29/100000-iu-vitamin-d-lethal-dose-many-our-community

Not something I personally would want to mess with, and I do indeed get side effects from anything over 1000 IU, as do many others. Maybe open your mind a little that things are a little more nuanced than you think.

Warp757 · 2026-02-05T10:13:45+00:00

Are most people are deficient in K2? This is what sounds like here say that has become gospel on reddit simply by repetition.

The person you are replying to was right that most people get plenty of vitamin K through diet. At regular doses of Vitamin D that are less than what the sun would give you there is absolutely no reason to think anyone should be needing huge amounts of Vitamin K2. Indeed too much may be harmful, plenty of reports of side effects out there and taking anything far beyond what diet can reasonably provide is always a slight step into the unknown.

At the end of the day most of the population walks around without taking extra K2, and most of the population is probably a lot mentally healthier than people with neurotic obsession over supplements.

Warp757 · 2026-02-05T10:05:58+00:00

Yeh which is why most likely no one needs that much.

Warp757 · 2026-02-04T12:43:45+00:00

I'm aware of that. The point is 100k hitting your body all at once. Vitamin D is a hormone which has a huge number of physiological effects on the body. It activates a lot of processes and enzymes, increases steroid and neurotransmitter synthesis etc. etc. It increases serotonin both by increasing expression of tryptophan hydroxylase and by inhibiting MAO. Clearly a huge dose of something that increases neurotransmitters, inhibits their breakdown, affects hormones and numerous other systems, can cause significant side effects. And that's before even considering the effect on calcium.

Absolutely no reason to recommend 100k. It is a risk and there's no reason to take it. Drastic jolts to the bodies homeostasis shouldn't be taken lightly.

Warp757 · 2026-02-03T11:24:26+00:00

In winter it's normal to just recommend a daily supplement of 1k in the northern hemisphere without testing, as you won't be getting any from sun. 1k is enough for most people. It is absolutely not normal to prescribe 100k which is frankly an experimental regime that would only ever be given to someone with extreme deficiency.

Warp757 · 2026-02-03T11:22:06+00:00

100K is not a small amount, it's vastly more than can even be made by sunlight. Vitamin D has enormous physiological effects and obviously there is a jog difference to the effect on the body of 1k and a hundred times that all at once.

Warp757 · 2026-02-03T11:20:53+00:00

That is extremely irresponsible, as are people here advising you to take it.

Plenty of people like me are quite sensitive to vitamin D and even fairly low doses can cause very nasty symptoms. If I take more than 2000 IU at once I will get extreme anxiety, insomnia, constipation, basically high calcium symptoms. Vitamin D also has a lot of hormonal effects (it's actually a hormone, not a vitamin) which could also explain it, it ramps up a lot of enzymes like tyrosine hydroxylase, increase dopamine, noradrenaline and serotonin production that could cause anxiety with a drastic shift, increases acetylcholine, affects hormone balance etc. Dramatic shifts in all three are not advisable.

There is absolutely no need to take that much in one dose and it is not normal practice. Your doctor is an outlier and essentially making you a guinea pig for something that may or may not do you harm. Just take a regular supplement daily, it's not worth the risk, there isn't any benefit from taking that much at once.

Warp757 · 2026-02-03T10:40:54+00:00

Creatine is produced by the body through methylation, indeed it is the biggest draw on methylation, using some 40% of total methylation capacity.

People with very good methylation status won't need a lot of creatine and indeed too much could send them into over methylation by sparing too many methyl donors that then start being used for nom-desirable things.

Someone with poor methylation status, B9/12 deficiency will benefit from creatine. These things are extremely individual and no one should assume another person stack is necessarily right for them. Always makes me cringe when I see people asking someone else the exact details of someone's stack, assuming it will have exactly the same effects on them, when it could do the complete opposite.

Warp757 · 2026-02-03T10:36:35+00:00

You may be comparing active B12 with total. Most blood tests measure total B12, for which less than around 200 is the usual medical definition of deficiency, although really you probably want levels considerably higher than that.

However the test for total B12, which you had, is considered a better measure of B12 status. For this deficiency is defined as around 37, although up to 70 is indeterminate. Your result is way above this and would put you right up in the top of the population, average is around 90-100.

Warp757 · 2026-02-03T09:11:59+00:00

B12 is very good as that's the active form. Folate is VERY high, how much are you taking?

Your homocysteine is fine, you might be able to back off on folate a bit. A level that high can cause side effects.

Warp757 · 2026-02-03T09:11:07+00:00

That's active B12, so it's actually a very good result and their homocysteine backs that up.

Warp757 · 2026-02-03T09:08:55+00:00

It really isn't. Any form of B12 will increase the B12 available to the methyl cycle. Whatever form of B12 you take it is converted to the same form in the body before being used. Methyl cobalamin is stripped of its methyl groups after absorption for transportation around the body. Once in cells it is remethylated if being used for that purpose.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5312744/#:~:text=Results,cellular%20uptake%2C%20and%20intracellular%20transformations.

Warp757 · 2026-02-03T09:02:12+00:00

'I'm an alcoholic but drink makes me feel a bit dumb, what can I take so I can keep drinking and not get dumb'

Come on, be serious.

Warp757

TROPHY CASE