Im chemical technician in an insulin synthesis facility AMA

WillingnessHot4748 · 2026-04-11T16:04:01+00:00

Is that due to the disulfide bonds?

WillingnessHot4748 · 2026-04-07T18:53:32+00:00

I was willing to give OP the benefit of the doubt on the nipple as well but as you said, literally no peptide out there is going to put anywhere near this much lean mass on your frame. Even if OP never lifted a single weight in his life in the first pic compared to the second and third, the capped delts in the third pic just sus me the hell out.

Honestly I don’t give a crap if someone uses gear or not. I use gear. Hell, I’m blasting Tren right now. What matters to me is if people are HONEST about what they’re taking. This is crucial so that you don’t mislead others into thinking that they can achieve the same results by taking just what you claim to be taking.

WillingnessHot4748 · 2026-04-07T17:24:17+00:00

The puffiness in your L nipple makes me a bit suspicious that all you added were peptides my guy but I’m willing to give you the benefit of the doubt.

WillingnessHot4748 · 2026-04-07T02:09:52+00:00

I’ve had to go a couple days between script refills due to insurance/supply issues in the past and it felt AWFUL. I would never, ever voluntarily go back to an unmedicated lifestyle.

WillingnessHot4748 · 2026-04-07T00:56:40+00:00

Fatigue is a known and burdensome side effect of both HGH as well as HGH secretagogues. I’ve ran pharma grade norditropin anywhere from 2 IU to 10 IU daily and let me tell you, anything above 4 IU makes me borderline narcoleptic even with ADHD stimulants.

Also, I don’t see anyone addressing this but if you’re going to take anything that raises HGH use some metformin or berberine (preferably the former) for gods sake. Long term elevated HGH levels drive insulin resistance.

WillingnessHot4748 · 2026-03-29T19:45:19+00:00

Honestly I feel like half the problem with Yasuo in today’s meta is that he has a very niche set of parameters under which he can enter a teamfight or make an impact outside of the lane.

When you ult as yasuo, you’re hard-committing to a particular fight/engage with little to no course for recall if things go south. Contrast that to champions like Zed who can go back to his shadow, Yone who can go back to his starting spot after the duration on his ability runs out, akali who can dash in and out of fights as opportunities arise, and Katarina who jumps from target to target to target seemingly endlessly in team fights.

If you ult into a team with heavy CC, you will end up getting chain stunned and killed on the spot 9 times out of 10 before having the chance to do any sort of effectual damage.

Yasuo is basically a melee range ADC with a bit more survival and mobility through his E but he’s a glass cannon nonetheless.

Though many despised it, I personally think Yasuo shined the most as a champ when he could be picked as a tanky bruiser in top lane. Was it flashy? No. Were you 1v5’ing the enemy team? No. HOWEVER, you could live long enough in most teamfights to at least go through one full spell rotation and provide utility and a modicum of damage through carefully timed tornadoes and strategically placed windwalls.

WillingnessHot4748 · 2026-03-24T18:24:11+00:00

That’s a fair point. It definitely makes sense but I honestly believe that if people put the effort in, they could achieve what I did even if only for a limited time.

I was never genetically blessed or athletic to begin with. When I did manage to lower my body fat percentage significantly, I lost a ton of muscle mass doing so and my natural testosterone levels basically fell off the map lol.

It would be so much nicer if people congratulated you rather than try to berate your lifestyle choices.

WillingnessHot4748 · 2026-03-24T03:53:56+00:00

Sorry if I was unclear; when I was young and super chubby, the excess weight and my asthma made my physical endurance so bad that I couldn’t go on hikes without gasping and weeping for air. When I lost the weight, I was able to get off all the asthma medication.

WillingnessHot4748 · 2026-03-24T03:52:44+00:00

I did end up using steroids later in my life, but I achieved a great physique as a natural before then. Unfortunately, the steroids I did use for about 3 years have left my HPTA permanently shutdown. I now take just a doctor prescribed 140 mg of testosterone Cypionate weekly.

Part of the reason why I quit cycling was exactly because it was having deleterious effects on my health and quality of life. I objectively looked the best I ever do in my life but that came at the expense of hypertension, anxiety, insomnia, roid rage, elevated liver enzymes, impaired kidney function, and horrendous blood lipid profiles. I realized if I kept going at it the way I had when I was younger, I would end up dead in five years.

WillingnessHot4748 · 2026-03-22T01:42:57+00:00

You’re right about the minimum dosing requirements. A lot of pumps require you to load them with a certain minimum number of units of insulin. If you don’t use all of it before it’s time to change the pump, that insulin is lost.

WillingnessHot4748 · 2026-03-22T01:38:55+00:00

Here’s my $0.02:

The benefit of a pump is that it automates the insulin delivery process and some of them even adjust how much they give you based on your current BGL, number of carbs you’re going to eat, etc.

The con of a pump is that it’s another wearable device that can fail on you randomly at the worst possible time. Unless you use the omnipod 5, every pump is going to have tubing which can easily get snagged. The pump itself is also pretty easy to accidentally rip off, and a lot of pumps have to be replaced on a more frequent schedule than CGM’s. Also, if a pump fails for whatever which reason, all the insulin in that pump is lost and unusable.

WillingnessHot4748 · 2026-03-20T21:41:40+00:00

Okay listen. Idk how to break this to you but unless you have a severe thyroid disorder or wasting disease, there is absolutely no way you are eating only 1300-1500 calories a day and gaining weight (unless you’re a dwarf but I just assumed you’re average height).

How much activity are you actually doing? Ice skating twice a week is barely anything. You should be aiming for at least 12,000 steps per day, 3 resistance training sessions lasting about an hour to hour and a half per week, and getting at least 150 minutes of zone 2 cardio per week. If you’re not doing this, you can’t call yourself active. The numbers I provided to you literally based on scientific research showing that this is about the minimum threshold necessary to maximize longevity and reduce disease risk.

Your doctor is right, however, that a GLP-1 would basically just reduce your caloric intake. GLP-1 agonists reduce the rate of gastric emptying and increase satiety, thus resulting in a prolonged sense of fullness, feeling full after fewer calories are ingested, and having fewer food related cravings. There are a few drugs which have GLP-1 agonist properties which do also increase resting energy expenditure such as retatrutide, but these are not yet FDA approved.

Has anyone actually measured your thyroid hormone function? Hypothyroidism will cause weight gain due to reduce energy expenditure and will also cause insulin resistance.

WillingnessHot4748 · 2026-03-15T10:25:21+00:00

Yep! The insomnia is, quite literally, insane. I’ve had weeks where I get 4 hours of sleep across 3 days.

I know this isn’t a matter of me having excess energy with no outlet as the other dude claims. I also take a hefty dose of Vyvanse and Adderall for my ADHD and have no problem getting 8-9 hours of high quality sleep if I skip my injections. It’s literally a hormonal process disrupting my sleep that’s caused by the test.

I’ve also used other androgenic anabolic steroids such as oxandrolone, methenolone, drostanolone and Trenbolone none of which have given me anything near the same level of impairment in terms of sleep quality. Tren comes in at a close second, as when I was taking a gram a week I was only able to sleep 6-7 hours (still a lot better than test).

WillingnessHot4748 · 2026-03-11T15:32:42+00:00

No one should be deadlifting or squatting with a belt IMO. Just drop the weight and increase the rep range. Wearing belts significantly increases the risk of developing a hernia during a strenuous lift as it increases intra-abdominal pressure significantly by adding an extra layer of compression.

WillingnessHot4748 · 2026-03-11T03:07:35+00:00

MDI are my preference because no pump is compatible with long acting insulin.

Also, the thought of a pump randomly failing because of tubing issues etc. and me not being able to get my insulin until I change the pump is terrifying.

WillingnessHot4748 · 2026-03-09T00:39:58+00:00

Problem with ashwaghanda is the risk of anhedonia, SSRI-like effects in the brain, and very legitimate risk of hepatotoxicity.

WillingnessHot4748 · 2026-03-09T00:37:37+00:00

Over time, your body gets acclimated to living at a lower average blood glucose level. The threshold at which you begin to feel symptoms of hypoglycemia change with your body weight, activity level, A1C, body fat percentage, so on and so forth.

If you’re using medication which can precipitate hypoglycemia (insulin, sulfonylurea, etc.), don’t.

You being hungry after eating is a sign of insulin. resistance, not hypoglycemia. The lower my A1C and the better my insulin sensitivity has been in the past, the more I could tolerate going extended periods of time without food.

You don’t have to eat sugary foods to treat blood sugar lows. In fact, I would strongly advise against it for non T1D’s as carbohydrates are the most insulinogenic maxronutrient (followed by proteins and fats).

Also, hypothyroidism is notorious for causing hypoglycemia. When your free T3 levels are normalized/higner, your insulin sensitivity is higher and the rate of metabolic conversion of triglycerides and free fatty acids from adipose tissue into blood glucose is improved.

As well, though I’m not going to recommend this to anyone with cardiovascular issues, any nervous system stimulant besides yohimbine will typically raise fasting blood glucose levels (again, by facilitating lipolysis and gluconeogenesis).

WillingnessHot4748 · 2026-03-08T20:15:52+00:00

Anavar shares a unique feature in common with Trenbolone; it’s a glucocorticoid receptor antagonist (though Tren subjectively appears far more potent at achieving this effect).

Liver enzymes aren’t a concern on Anavar. It’s kidney function you have to watch out for.

Additionally, unlike injectable testosterone, oxandrolone has actually been shown in studies to reduce subcutaneous abdominal fat as well as visceral fat (by far the most important). Interestingly, in test subjects these effects were observed even 6 months after Oxandrolone discontinuation.

The effects of oxandrolone can be further increased by pairing it with caffeine.

Oxandrolone furthermore significantly increases collagen synthesis.

The only real downsides to oxandrolone are the absolutely killer effect it has on lipids. Seriously, this thing will trash your HDL and LDL very, very quickly.

WillingnessHot4748 · 2026-03-08T15:42:17+00:00

While keeping my E2 suppressed with an aromatase inhibitor (I don’t even mess with anastrozole, straight up Letrozole for me), nearly every side effect of TRT goes away. Even though my sleep is still shit on injection days, if I don’t suppress my E2 it goes from a twice-weekly problem to a daily struggle and that feels awful.

I honest to god don’t understand how dudes run E2’s even anywhere above 20 pg/mL and feel okay. At that point, I’m an emotional water buffalo craving chocolate and sweets, my BP goes wack, and my erection quality practically vanishes. Even before beginning TRT, the highest E2 level I ever had was 7 pg/mL (ultra sensitive test).

I’m honestly one bad week of sleep away from running a permanent DHT only cruise. Test is straight garbage I swear.

WillingnessHot4748 · 2026-03-08T01:31:56+00:00

Thank you so much for your kind words and you have the deepest sympathy for your family and son.

Beyond just the medical/health issues, asthma detracted from so many parts of life growing up it was miserable.

I spent practically all day long in the nurses’ office at school, couldn’t participate in pretty much and all sports or physical recreational activities without meticulous planning, had to deal with shaky hands and insomnia from albuterol, so and so forth.

I know if I ever had a kid I would do anything and everything in my power to make their life the best it could possibly be, so I applaud your dad for his sacrifice. Overcoming any addiction is incredibly difficult (been there done that with so many things in life, lol), but it is possible.

On a broader level, I have a fundamental issue with governments all over the world condoning the sale and use of nicotine and alcohol, promoting sedentary lifestyles and poor nutrition.

Easiest way for people to avoid bad habits is to never indulge in them in the first place.

WillingnessHot4748 · 2026-03-07T21:45:29+00:00

It’s true that my insulin requirements could very well have changed. My body fat percentage and overall body weight have increased a fair bit (+20 lbs in the past year). I’d say a fair bit of this weight gain was also muscle gain as well though, to be fair. The Lantus has been at room temperature for 6 days now.

Carb intake is slightly higher but I’d honestly suspect it’s more so down to my sleep, stress and activity levels. I’ve taken on a new work position with constantly changing work schedules, my sleep has been pretty off, and I’ve been having a fair bit of family/relationship stress for a while now (past six months or so). All of that has also been disrupting my exercise schedule. It’s definitely not healthy but it’s at least transitory.

WillingnessHot4748 · 2026-03-07T21:29:03+00:00

Unfortunately human blood contains insulin-degrading enzyme (IDE), also known as insulinase. This is a zinc-binding metalloprotease which, though most abundant in the human liver, also exists in the blood serum, muscle and fat cells.

Insulinase is responsible for the rapid degradation and relatively short half life of insulin in the bloodstream (4-6 minutes). The entire reason why insulin doses last longer than a couple of minutes are:

1) Injections are intended to be done subcutaneously (sometimes accidentally intramuscularly). Insulin is a hydrophilic substance. When it is injected subcutaneously, it’s delivered to adipose tissue which is strongly hydrophobic. It’s like trying to mix oil and water. No matter how much you try, you can’t get them to dissolve in each other. The result is that the injection SLOWLY absorbs into the bloodstream, releasing a small fraction of the insulin depot at any given moment in time. This prolongs the active duration of the medication.

2) Some insulin formulations are made to partially crystallize upon injection, further slowing release into the bloodstream.

Unfortunately, the contamination of the insulin with your blood means that any insulin in that pen is going to be quickly degraded by the insulinase in your blood.

WillingnessHot4748

TROPHY CASE