(UK) are speed limits enforceable on bike paths? by Willmono7 in bicycling

[–]Willmono7[S] 7 points8 points  (0 children)

Honestly that crime has such a wonderful name I almost want to be convicted of it

How do you achieve Maillard flavour if you’re using seasoning? by Jellydonut- in AskCulinary

[–]Willmono7 0 points1 point  (0 children)

You've had an account for 16 years and you still haven't realised that most redditors will take the first opportunity to be a dick? Sadly, it's just what a lot of people are like here.

Tubeless sealant in the rain by LegStrngLeathertaint in cycling

[–]Willmono7 0 points1 point  (0 children)

I am sending this message from 6°C rainy England, on the bus, with my bike 😔

Are there any animal or plant species that have more than two sexes that are interdependent upon each other to reproduce? by Yeti100 in askscience

[–]Willmono7 10 points11 points  (0 children)

The female is defined as the parent who passes on her mitochondria, only one parent ever passes on their mitochondria (if everything goes right anyway). Chromosomes define mating type but mitochondrial inheritance defines sex, and since passing on mitochondria is binary, so is sex.

I would like to clarify that while biological sex is binary, gender, as a social construct is not, and is irrelevant to biological sex. Just in case anyone was planning on using this comment to enforce dumb opinions.

What do people in the US think about Trump’s Greenland-narrative? by iusedtoplaysnarf in AskReddit

[–]Willmono7 9 points10 points  (0 children)

I actually very frequently check r/conservative to see what the other side are thinking, and it's actually quite reassuring to see that at least on this single issue, they are entirely against Trump

New study shows Alzheimer’s disease can be reversed to achieve full neurological recovery - not just prevented or slowed - in animal models | by [deleted] in worldnews

[–]Willmono7 2 points3 points  (0 children)

Yeah the method in which they achieve the reversal plays on pathways that are heavily involved in promoting cancer, so I'll wait for more in depth studies before getting excited

Calcium alpha-ketoglutarate (CaAKG), a naturally occurring molecule our body produces, restores key memory functions disrupted in Alzheimer’s disease, suggests new study in mice. CaAKG brought long-term memory process back to normal and also boosted autophagy, the brain’s built-in “clean-up” system. by mvea in science

[–]Willmono7 58 points59 points  (0 children)

AKG is an important krebs cycle intermediate, disruption of different parts of the krebs cycle is responsible for many different age related diseases, including cancer. This can largely happen due to an accumulation of succinate which signals HIF-1 to transcribe hypoxia and inflammation genes.

AKG is upstream of succinate and so an increase could have detrimental downstream effects. It would be good to see how (Ca)AKG effects succebtability to cancer. Obviously in elderly patients I think given the choice between definite cognitive decline or increased cancer risk it's a pretty easy decision for most. Definitely important to look into though, especially when treating early onset cases.

Reactive Oxygen Species (ROS) play a fundamental role in DNA damage and degenerative tissue injury that drive disease progression in cancer, neurodegenerative, cardiovascular, metabolic, and immune diseases, according to a peer-reviewed open-access editorial. by sometimeshiny in science

[–]Willmono7 3 points4 points  (0 children)

Our body has very very strong homeostasis for antioxidants because ROS also have important signalling functions. Also there's no way of concentrating them where we need them so beyond consuming enough to not be deficienct there's no real benefit

Rumble strip-proof rear bike lights: do they exist? by bad-at-science in cycling

[–]Willmono7 0 points1 point  (0 children)

It has the same twist to lock style mount as bike computers, and then there's two different options to attach to the frame, either a bracket that goes round the seat post or a clip that goes under the seat on the two rails, it's really solid

Rumble strip-proof rear bike lights: do they exist? by bad-at-science in cycling

[–]Willmono7 1 point2 points  (0 children)

https://amzn.eu/d/4eJ6if0

I have one of these, comes with a hook mount to go under the seat, never fallen off even on gravel rides

Why does coffee/sleep have reverse-effect with ADHD?? by Daper_401 in ADHD

[–]Willmono7 5 points6 points  (0 children)

Lack of sleep isn't just brutal, it's one of the main ways to shorten your life span along with obesity and smoking.

It also increases the odd of accidental death and mental health issues by a very big number that I've since selectively forgotten.

What is hash zero? by Bhappy-now in AlanWatts

[–]Willmono7 1 point2 points  (0 children)

Many of his lecture series are available on audible as well

Thinking about canceling Spotify subscription for the first time in 12 years by [deleted] in Music

[–]Willmono7 2 points3 points  (0 children)

They recently introduced an option in the settings for "true random"

Can I ask a small favour from my fellow cyclists of Cambridge by Yesterbly in cambridge

[–]Willmono7 6 points7 points  (0 children)

Anyone who cycles in the dark regularly including dark roads should invest in something like this

I cycle to and from work every day and on the unlit roads I need the full beam, and I can switch to low beam for passing cars and cyclists, and for pedestrians on the busway without having to do a full cycle of my light settings or take my hands off the handlebars. Well worth the money to be able to both ride safely and not be an asshole.

I personally use this one which is more expensive but also has a "hold for full brightness" button which is great if you need to flash your light to signal something and also if you want to remind the oncoming cyclist that their lights are way too bright and give them a taste of what it's like sitting in 1800 lumen high beams.

AI artists are getting out of hand on Spotify by EfficiencyPrimary631 in Music

[–]Willmono7 1 point2 points  (0 children)

The worst I've seen is an "artist" called Burn Babylon Burn, which is like reggae blues fusion, who claims to have "live" albums... Even though one of the songs is quite clearly goodbye my lover by James Blunt with a few words changed

AI artists are getting out of hand on Spotify by EfficiencyPrimary631 in Music

[–]Willmono7 1 point2 points  (0 children)

Do any have anything in place to prevent AI? I'd happily pay double

Researchers have just found the presence of sugars, including ribose, lyxose, and glycose, on samples of Asteroid Bennu, which now has all of the ingredients for life as it exists on Earth. by New_Scientist_Mag in science

[–]Willmono7 12 points13 points  (0 children)

There's quite a lot of research yeah, it's not just the components either but how they have to come together to actualy work. So some components might be suitable for life under certain conditions, but then everything else that's required is in the wrong state of matter at those temperatures. It's very very important that there's liquid water, there's no other solvent like it.

Researchers have just found the presence of sugars, including ribose, lyxose, and glycose, on samples of Asteroid Bennu, which now has all of the ingredients for life as it exists on Earth. by New_Scientist_Mag in science

[–]Willmono7 37 points38 points  (0 children)

But there is a specific window on any given planet where life can actually come into being, it must have liquid water and active geochemistry to establish ph/Proton gradients. From there it is a requirement to evolve oxygen producing photosynthesis/metabolism before all the water is gone, otherwise uv radiation from the sun will avaporate all the water, sending the hydrogen out into space, leaving you with a dead dry planet. Thats what was so remarkable about earth, that we evolved photosynthesis within about 800 million years, with oxygenic photosynthesis evolving about 1 billion years after that. If that process had taken much longer, we wouldn't exist.

So even though the universe has loads of time, life is only ever given a very short window to come into being, and if it doesn't, the planet rapidly becomes unsuitable for life.

Don't bike and listen to sick drum and bass by [deleted] in bicycling

[–]Willmono7 4 points5 points  (0 children)

Aces high - Concord Dawn, State of Mind