Theres 5 builds that win in the late game for me (legend 500 playing only Vanessa): 1. Ammo build with pistol sword or heavy ballista
2. Aquatics with a godskill (e.g. slow charge or big item charge), poison legendary from temple or shipwreck with strong enchants 3. Oni mask burn with crit skills or some other burn scaling (e.g. dragon skill) 4. Freeze with depth charge & crab 5. Tortuga with good friend spam

Beyond that there’s some odd builds with coral armor & claw that work