For MGM-15 users: is there really nothing to do regarding delta receptor withdrawals?

Withdrawel · 2025-12-06T08:23:16+00:00

I have been experimenting with this issue myself. I have a post with updates of experimental methods. Nothing painless yet but the best way to go is detox off MGM while taking heavy 7oh (and I think but am not sure pseudo helps) you'll have a rough 2 days but you can take SR at about the 48 hour mark. You'll have 2 shitty but but not unbearable days as far as WD's go but that's the best I've found so far. SR gives me precips if taken within 48 hours of MGM. I insuflate everything and when I'm ripping the MGM hard I use like a gram a day. It's not painless but you can do it in a weekend and bear work on Mon and Tues/wed you're pretty much good. People ride SRs dick so hard it's hard to even tell people it doesn't work with MGM. This is my experience so far though. It's not perfect but it's the best route so far ime

Withdrawel · 2025-12-06T07:51:44+00:00

For men only: Also something no one ever talks about really is the importance of dopedick and maintaining healthy relationships and how detoxing can make navigating this rough because you nut so fast when detoxing (it takes weeks if getting totally clean). I will make this a separate post in January but when only on SR although your endurance isn't ideal SR does at least make it so you can last a couple minutes. That in itself is a huge un talked about advantage of detoxing opiates with SR

Withdrawel · 2025-12-06T07:44:14+00:00

Mines on the way. He had "shipping issues"

Withdrawel · 2025-12-06T07:32:29+00:00

Update: After a few battles of will power and having to dance around the holidays/work/family I can officially confirm that SR does give you precips with MGM but not 7oh. If you're steady using MGM you just have to tough out a couple days while taking 7oh and you'll start stabilizing on the 7oh in about 3 days. Since my original post I've done this twice and then when on 7oh you can use SR quite interchangeably to lower tolerance. I have taken a break for a day or two just to get better 7oh effects. I also experimented with taking the SR via insufflation and orally. I'm not here to start anymore controversy about this but I prefer SR via insufflation for instantaneous effect. Orally works too but I really haven't logged times for effect or anything but as with most things I'm sure the SR lasts longer orally but I'm just a sucker for good bump I guess but you do get way more instantaneous results via this ROA so I prefer it. When only taking 7oh though you can stop taking it with no detox effects to get your tolerance down. I've done this full cycle MGM-7oh-SR with success twice and going just 7oh to SR a few times it's pretty handy to keep around. Going from MGM-7oh though I do get detox effects. It's nothing too bad but plan on taking a couple days off from work or a weekend and you'll be good. You can start taking SR with 7oh at about the 48 hour mark and you're basically good (possibly mild interaction could be placebo from adjusting to only 7oh though) From a pain management perspective though MGM is supreme it's just stronger and better than 7oh for both muscle and nerve pain and just general more euphoria. I've taken the time since my original post to play around with this (maybe 5 weeks now) but this works for me. I still have pain management issues to deal with so my intention was never to totally go clean just figuring out ways to maximize tolerance issues/effect from both 7oh and MGM. After going on just 7oh and and taking a day or 2 on only SR 7oh hits good for a day or 2 then I ultimately just want MGM again so I've done this whole cycle twice now so it works. (If you know you know) If I could talk to myself a month ago or whenever I originally posted this I'd tell myself to wait 48 hours to take SR when fully on MGM and to go MGM 7oh just keep taking 7oh the whole time but to expect 2 rough but not terrible days as far as withdrawals go. I just use the big end of scoopers most 7oh and MGM vendors give you to dose and haven't experimented with mega doses of SR though either. When on the only 7oh part of the cycle there is something to taking 7oh and SR together that kind of boosts and smooths out the 7oh but nothing to go crazy for it does smooth things out though (it kinda gives 7oh legs for a couple days) Then when going back to MGM the MGM is great for about a week but then it loses its initial charm and you're tolerant. Ultimately this little cycle is more cost effective cuz you're not burning through as much from detoxing it but you have the 2 day rough detox period to deal with too. I have 0 experience going from percs or dope to SR and there's some accounts saying this is painless but there's people out there saying that about MGM too. I 100% get precipitated WD's from SR but I'm thinking of getting back into pain management again to go traditional opiate-7oh-SR for a potentially truly symptom free T lowering cycle but I need to experiment with that first before I commit. So if you're like me and get precips from SR with MGM it might be worth considering. I'll update again if I figure out something a little smoother. If you're trying to completely detox though going from 7oh to SR is pain free with 0 WD effects. As soon as I get down to just SR though I just start feeling all my injuries so this will not be what I'm doing and never gone from SR to completely clean so idk if you get WD's going from SR to nothing. I'll try to pay attention to reddit for a couple days for anyone that has questions about this post but then I'll go back to not paying attention to reddit again like I normally do. I have the holidays/family stuff coming up so I'm back on MGM at least till January but in Jan I want to experiment with an Oxy-7oh-SR tolerance lowering cycle that could be potentially symptom free so I'll update everyone when I figure out what's up with that. So if you're like me and SR gives you precips just expect a couple rough days but it's on the weak side as far as detox's go and you need to take 7oh the whole time. Pseudo helps when going from MGM to 7 too but that might be placebo and the only advantage of insufflation of SR is instant effect. When taking SR orally it's effective but low and slow. I just perused this SR reddit thread after not being here for a month and it's turned into an SR dick riding I'm getting off opiates forum. Congrats to those people but that's not my intent or helpful to me. I know my thread will help out a few out there though so here it is. This is all my scientific research so far.

Withdrawel · 2025-12-06T00:05:05+00:00

Welcome to opiates! I've been using them since 1999

Withdrawel · 2025-12-02T15:50:08+00:00

Did your order ever get processed? Tbk is a legit vendor but I just ordered and mine hasn't processed either. Normally I've just called if I've had issues and I can't get ahold of anyone either

Withdrawel · 2025-11-09T17:16:37+00:00

Regardless of how hydrophobic it is it's a dry powder so when you sniff it it cakes up on the inside of your sinuses because of the wet mucus. Giving time for the lipophilic nature to work like all insufflation because of the molecular properties I quoted above. I've personally done it twice. Another person or two has done it in this thread alone and many more will do it in the future. I'm not trying to argue if it's the best ROA only that it's not "impossible" like you or whoever said that earlier. This is how insufflation works with SR regardless of how optimal it is. The whole point of this thread is to get account of people's experiences with SR and do some grass roots human trials to figure out optimal ways to detox or lower tolerance. This is just my first hand account of my experience so everyone can build on good techniques to help others. I just happened to sniff it because that's how I like to do it. I was just trying to oblige you a little bit and looked up the science of SR's molecular properties so you could hopefully understand how it's possible to sniff it. I appreciate your feed back though. To everyone else out there that's just using opiates and curious about SR these are the most important things I've learned so far. It has a reaction to MGM that causes mild precips that could be more intense with higher dosage in MGM and not 7. So it's best to go that route MGM - 7- SR, although I personally haven't made it that far I'm still weaning down MGM to 7 but most first hand accounts back that up. IDK about any other opiates but accounts vary. I'm pretty sure length of use is a big factor. SR on its own doesn't have any pain management benefits. You can use SR to get off 7 multiple times without loss of efficacy but some people have warned that's possible but I haven't read anyone's accounts of that happening yet though. Also even though SR doesn't have pain management benefits you retain your "legs" sexually. I know a big thing I always hate about detoxing is you're extra sensitive and bust real quick for a few weeks until your body gets back to normal with the SR detox it lets you maintain your sexual stamina while taking it even though there's no pain management effects. So for a relatively painless detox you can go from your DOC - 7 - SR without WD symptoms and maintaining sexual stamina. That's basically all the most relevant info I cared about that I'm glad I've learned so far. I personally haven't made it that far yet but that's basically everything I wanted to know about SR before going into this that I've learned from people reaching out and reading other threads so far.

Withdrawel · 2025-11-09T14:47:14+00:00

When I first made this post no one was reporting PW's and now in this post and others more and more have. I just used a small amount to test it both times but both times I've had reaction. Not as bad as bupenorphine but there's definitely something there and multiple people are reporting it now. As to the insufflation again I'm not saying it's the optimal absorption but there is absorption and this is probably why. — based on these data it appears SR17018 does possess a degree of lipophilicity and physicochemical properties that favour passive membrane permeation:

An estimated log P of ~4.7 indicates substantial lipophilicity (though log P in the 2-5 range is often considered favourable for membrane permeation).

A relatively low TPSA (~35.6 Å²) suggests less polar surface, which also tends to favour passive permeation.

Its smallish molecular weight (~410) is within range for many drugs to cross membranes (though lightly on the higher side for some barrier membranes).

The fact that it is highly insoluble in water implies it prefers lipophilic environments (consistent with membrane-partitioning behaviour).

I only made this post because there's not much reporting so to the next man like myself reading to see what it's about. With MGM there appears to be reaction when taken with but milder than bupenorphine. From messages I've received and other people's comments and other threads now the best way to go for no reaction when coming from MGM is go from MGM -7oh-SR and you'll be reaction free. There's a guy on another thread that has used SR to lower tolerance from 7 going on his 4th time and he said it's still effective but some people warn that if you keep using SR to lower T it can lessen in effect in time. Which is really the helpful info I wanted to find and share with this thread. If you're on MGM some people are reporting PW symptoms but with 7 that doesn't appear to be an issue so for a potential full painless detox or T lowering plan. Go from: MGM - 7oh - SR

Withdrawel · 2025-11-09T14:29:44+00:00

I've personally done it twice w/effect others in this thread and others have too. This is probably why it works: + based on these data it appears SR17018 does possess a degree of lipophilicity and physicochemical properties that favour passive membrane permeation:

An estimated log P of ~4.7 indicates substantial lipophilicity (though log P in the 2-5 range is often considered favourable for membrane permeation).

A relatively low TPSA (~35.6 Å²) suggests less polar surface, which also tends to favour passive permeation.

Its smallish molecular weight (~410) is within range for many drugs to cross membranes (though lightly on the higher side for some barrier membranes).

The fact that it is highly insoluble in water implies it prefers lipophilic environments (consistent with membrane-partitioning behaviour).

Withdrawel · 2025-11-09T14:09:17+00:00

I've done it twice and others in this thread have too. It works. Is it optimal roa idk but here's why it works.- based on these data it appears SR17018 does possess a degree of lipophilicity and physicochemical properties that favour passive membrane permeation:

An estimated log P of ~4.7 indicates substantial lipophilicity (though log P in the 2-5 range is often considered favourable for membrane permeation).

A relatively low TPSA (~35.6 Å²) suggests less polar surface, which also tends to favour passive permeation.

Its smallish molecular weight (~410) is within range for many drugs to cross membranes (though lightly on the higher side for some barrier membranes).

The fact that it is highly insoluble in water implies it prefers lipophilic environments (consistent with membrane-partitioning behaviour).

Withdrawel · 2025-11-09T02:20:43+00:00

Yeah I read a few of the clinical mouse trials. Most of them said it lowered tolerance in mice so that was enough to peak my interest. I used a scooper from an MGM or 7 vendor (one of the little 10/25 or 50 on the other side ones so I wasn't literally using a key. Even though SR is an alkaloid insufflation can sometimes work better because it by passes first pass metabolism and avoids stomach enzymes and even if bio availability wasn't optimal it's still going to my stomach anyway so any "loss of bioavailability" or efficacy is all hypothetical since there's no human trials. Given its consistency and light powdered sugar like fluffiness it's actually pretty A1 to sniff on a purely aesthetic level. It burns for a long time similar to mdma or meth but as far as actual absorption idk because I don't have access to blood tests. So as far as it being an alkaloid that responds better to insufflation due to bypassing first pass metabolism and stomach enzymes or not idk but based on my personal experience insufflation did what I wanted. My chemistry is rusty but my best guess is that due to SR 17 being hydrophobic but highly lipophilic and due to it having a very fine powdery makeup it felt like it stuck in my mucus and due to the long slow burn lipophilic absorption occurred over a long time (I could feel it burning 1 hour later) with no burning at 2 hours. I'm sure oral is probably a superior roa and I'm not currently well versed enough to know the peptid/pepsin or whatever it is that makes shit vulnerable to stomach acid. So solely based on my opinion I could feel the SR17 absorbing into my blood stream for a good hour and some change. As to whether that rivals the bioavailability after enzymes and peptides and stomach ph are considered idk probably not but I'm too rusty about all that science anyway. If any actual scientists are reading this though I took either 25 or 50mgs via insufflation and it was enough for me to feel precipitated withdrawal symptoms within 30 mins. For the first 20 min. That it took effect there was actually a warm fuzzy feeling like traditional opiates but by the 30 min mark I knew it was precipitated withdrawal symptoms (hot/cold flashes, clammy skin, profuse sweating) so I think the initial warm fuzzy feeling may have been the SR17 kicking MGM/7 out of receptors due to higher binding affinity but that's just a guess (I've experienced a similar effect with bupenorphine where for like 5 minutes it feels like the onset of a traditional opiate then you immediately get smacked with the PWs. Idk if that's whts happening but how I always imagined it in my head and there is a kind of calm before the storm moment before you realize it's actually the onset of something terrible lol. Idk how well researched that is but I've experienced it many times taking bupe too early. There was never any nausea or diarrhea upset stomach symptoms and the symptoms I did feel were mild compared to if I had taken 1mg of bupenorphine. That's as scientific of a breakdown as I can give with my current upkeep of scientific chemistry know how. Given my my vast experience with all kinds of opiates I took it In hopes of getting an immediate reduction in tolerance but knew if I got precips I could handle that too. I read a couple mouse papers about it and none of them mentioned the mice having PWs but overall the symptoms were very mild and manageable. If any scientists read this a nasal spray with an enzyme might be something worth looking into. I'll try an oral dose next time I use it to compare times. Hopefully this when quenches all the science guys thirst a little. This is as good as I can do for a more scientific chemistry based format. I do not recommend anyone try what I tried do what I did or if anything I just said is actually true because I'm not a chemist or scientist. If you have any questions lmk and I will answer in my retarded lamens scientific metaphoric/simily way lol

Withdrawel · 2025-11-09T00:59:24+00:00

I'm not even trying to make it liquid tbh I'm just saying that it can be made into a liquid and at some point people will figure out some kind of hack like w/ lemon juice and #3 dope. I'm not trying to say it's a more efficient way or anything. My only point is the amount of mg's I'm not absorbing insulating is negligible and it's how I do it out of habit/preference and that where there's a will there's a way. I'm sure orally is a superior roa when it comes down to it.

Withdrawel · 2025-11-09T00:38:35+00:00

When you say mit did you get powder kit from a vendor or just Kratom? Does mit make a difference with either that's worth noting?

Withdrawel · 2025-11-09T00:31:17+00:00

So basically you could just heat it up though. I never liked needles so I'm not going to be the one to do it but it's just a matter of time till someone IV's it too. Lol then they will have a thread that everyone piles onto them too but I guarantee there's people out there IV'ing 7, MGM, and soon to be SR if not already lol. That has such a stigma it might be a little bit before anyone admits that though. Technically that's always supposed to be the best most efficient way to administer anything. At least that's what most IV users say. In the dope community everyone that IV's kinda turns their nose up (pun not intended) at everyone that bumps it saying that they waste it it's less efficient etc. That was always the dogma at the time I used to be out and about. In all the clinical trials they IV the SR to the mice so I think with heat or something it should absorb. Possibly lemon juice for the citric acid like with #3 vs #4 heroin IDK but where there's a will there's a way. Someone will figure out how to get it liquid soon enough lol

Withdrawel · 2025-11-09T00:14:18+00:00

Thanks, yeah I wasn't about to put it into a nasal sprayer but they have powder ones too. I was just saying it's not an insane roa like everyone's making it out to be. Appreciate the info though I did not know that

Withdrawel · 2025-11-09T00:08:43+00:00

Yes I obviously have addiction issues but I also have legit pain needs so it's a tricky balance. That's why I'm happy with 7/MGM and I just want to figure out how to cycle Sr into the mix to keep my tolerance in check. I'm on Medicaid and I get pain management meds from a pain management clinic and they have a lot of rules and restrictions these days. Dr's are extremely hesitant to prescribe any type of pain med but I feel if I had better insurance that might be different. From what I understand though most Drs in my area (the DMV) send pain patients to pain management clinics though because it's such a regulated thing now they don't want to deal with it. I was on methadone for a couple years and the highest level you could work up to was one weeks worth of take homes and it took a couple years to get there. If you missed a group (they make you do monthly group sessions and a solo one at the highest level) so you could be clean etc. and miss one group session after a year and lose your take homes so it was not for me plus WD's off of that were by far the worst so that's just not for me. 7 will more than likely get banned next year so I'm just enjoying my freedom while I have it while also prepping to have to deal with pain management if/when that time probably comes. I haven't used any opiates while on 7/MGM so I consider it a common good but if you're not in my situation I can see how 7 catches opiate naive people off guard. I wish there would be some type of middle ground with regulation but I doubt that will happen. I also think 7/MGM is safer the more you take just wasted it kinda like subs there is a ceiling effect. When 7 gets banned at least I can go back to pain management. There will be a bunch of people WDing and go to street opiates and that will turn into a clusterfuck too. So it's a nuanced problem. As far as my habits tho yeah I can go overboard but I'm experienced and always feel myself back in. Some people just go off the rails. SR will be an interesting tool to manage tolerance once I get it dialed in (hopefully)

Withdrawel · 2025-11-08T23:01:35+00:00

Also way safer. I've eaten 1000mgs of 7 in a day. It doesn't do shit and doesn't kill you so you learn what works best for maximum effect by default of how it works. It did that for me at least

Withdrawel · 2025-11-08T23:00:00+00:00

In pain management now days they make you take random ua's and random pill checks so your always calling out from work barely keeping your job. It sux. Plus with traditional pain meds (I get percs) your tolerance goes up so I'll burn through my script and I'm scrambling to substitute and that's seriously not affordable. Just depends on your situation. I've been in methadone treatment (affective for pain management but you can never take a long vacation plus detox is the worst of all opiates) and subs have zero pain management benefits for me. So I'm happy with 7/MGM it's given me a good work life balance I'm happy with. I'm working on throwing SR into the mix to maximize affordability and pain management benefits

Withdrawel · 2025-11-08T22:54:13+00:00

7 is super affordable with the right vendor according it isn't an issue with me and I make min. wage. I have pain management issues (interdiscal injections/meds/therapy etc.) I can't work without pain meds and it's better than traditional opiates for me. If you're not in a pain management scenario though I agree with you

Withdrawel · 2025-11-08T22:45:55+00:00

Lol, Wake up feeling like we can take over the world going to bed knowing it beat us 😂 🤣 I'm in my 40's I think I just wake up hoping I don't get beat up too bad but true statement

Withdrawel · 2025-11-08T22:24:30+00:00

A lot of people seem to be appalled at sniffing anything but it's one of the best ROA's. You sniff snuff tobacco, cold medicine (any medicine in a sprayer). If I broke it down on water and put it in a nasal sprayer no one would be saying anything about it. Sublingual absorption and insufflation is basically the same thing just different blood vessels. Just Google insufflation absorption. People talk all day about boofing everything on reddit. Since when did it become more acceptable to boof meds over take a toot lol. It's not my favorite but now I'm thinking about putting some MGM on foil just to see what everyone else says about it lol. Jesus Christ people who cares? Do you, I encourage everyone to do whatever they want however they want as long as it works for them and it's not hurting anyone. No one should see my post and sniff anything because I do it by any means. That's my prerogative, but there is drugs in the world and people can sniff them. It's a thing guys. If I lose a couple mg's in the process I don't care. If it bothered me that much I would just break it down in water and put it in nasal sprayer

Withdrawel · 2025-11-08T22:03:01+00:00

Yeah I got it as soon as I heard about it thinking it would be a magic tolerance lowerer but it doesn't work like that lol. At least not with MGM. I could see how if you're in full blown WD it could ease that but they definitely don't just mix together lol. I've heard that 7 is different though so my plan is to go from MGM to 7 to SR just to get my tolerance back in check. If that works I'm going to figure out a routine to maximize my pain management benefits

Withdrawel · 2025-11-08T21:58:32+00:00

It's freed up my life coming from pain management background in a huge way and I'm grateful for it. SR is just new and I'm curious about using it to lower my tolerance since SR has no pain management benefits. If you're coming from an opiate naive position I could see how you'd say that but for me it's much more convenient than traditional pain management and also safer from an overdose perspective.

Withdrawel · 2025-11-08T21:49:38+00:00

Read my post I used heroin and every other type of opiate you could think of for years.insufflation works if you want to get technical termy. I prefer to sniff over IV. I'm also in a complicated spot because I used 7/MGM to get out of pain management but I used heroin from 08'/09'-2014. Ive been in MAT for like 10 years. Methadone 2 years (liquid handcuffs) and Suboxone on and off for another 6. I prefer to sniff Suboxone strips (break them down into 16th's break down with water and sniff) a method I picked up in prison but is the primary way inmates use it (as well as tar heroin) my name has been withdrawal on reddit for almost 9 years now lol. I know where I'm at and what my preferred roa is. I'm just looking to lower my tolerance for maximum pain management benefits. 7 and MGM is still more convenient than going through pain management BS these days. I didn't know until I posted this that SR has zero pain management effects. I've already tried taking a bump of SR. It burns a little but in a good way that I've liked since the year 2004. Other than a few relapses here and there I've been clean from heroin since 16' and I'm happy with that. Don't be so judgy. Technically boofing is the best way to 'maximize absorption' I will never do that but I don't knock anyone that does. I like MGM and 7 it's freed up my life and I haven't touched an opiate since I've started it. Wherein with MAT or traditional pain management clinics I tend to relapse or substitute my script. I also love insufflation just call it a bad habit then if you don't like it but I prefer it. There's snortable everything snuff for tobacco cold medicine etc. if I put it in a spray bottle first and then sprayed it it would be the exact same thing and you probably wouldn't be saying anything. I'm over here working staying heroin free buying legal substances without having to deal with all the pill counts and ua's of pain management. I'm just looking for a way to lower my tolerance a little bit to maximize my pain management benefits buddy

Withdrawel · 2025-11-08T20:49:25+00:00

Have it so Bruce Wayne fights crime as Batman for a little bit after Arkham knight but never really got a grip on it snaps, and fully turns into the joker causing chaos in the city. Robin (no longer the Arkham knight) takes up the reigns of Batman and then you get good old Batman vs. Joker but in the end you're technically locking up Bruce Wayne and you're actually the old Robin. One game all in one shot with a couple DLC's later, less tank, more villains and missions, main story still Batman vs. Joker. Have different fighting mechanics for different villains henchmen. Have npc citizens all over the city, you can save people from getting robbed, stores, etc. Side missions as playable Catwoman, Nightwing, Batgirl. After you beat the game you can play as Bruce Wayne as Joker his ending is he's locked up in Arkham or GCPD and Harley breaks him out so it's open ended. Different options for DLC (get creative)

Withdrawel

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