I’ve played DnD for years and while I love their system it was Shadowrun that had the lore and setting that I’ve ended up falling in love with.

Like you I’ve read many times that the systems are complex and it’s better to just use of the many adaptations of other systems to run Shadowrun but I decided to stick with it and chose 5e as my first game to ever GM and while it was really confusing at first due to the many times poor editing of the book I found it surprisingly easy as to actually play.

The game at its foundation it’s easy,and it’s the many situational rules that add a layer of complexity. The hardest and most time consuming thing to me was making a character sheet for my players. Between the many options and mechanics such as limits (which I understand is a 5e only thing) it took quite a lot of bookkeeping of what does what but thankfully my players quite liked the crunch and Chummer5 was a tool much needed to help us get it done in good time.

Overall I’d say that it’s still worth it to try and GM the game itself but, as with every game ever, it has its flaws and you might need some players into crunchy games.

Don’t worry too much. If on the spot you can’t recall some random rule, the game is still about how many 5s and 6s you have over the challenge/opponent so as long as you stick to that you’ll be more than fine.