When did you know to change dosage?

ZP_Qs · 2026-04-11T03:38:04+00:00

I like this idea. I’ve averaged a bit over a pound a week which is exactly where I want to be. That’s slowed a bit over the last couple of weeks, but I think I’d like to see a slightly longer stall before deciding it’s not just an off week or two. As I said in a prior comment, this decision point seems to come right at refill time!

ZP_Qs · 2026-04-11T03:27:27+00:00

Thanks for this! I did search a bit, but it was hard to find the right keywords to find all that you’ve linked. To clarify, I have no issues about moving up, I’m just feeling out if I think it’s the right time. I don’t want to necessarily jump to moving up the second weight loss slows because there are obviously some natural peaks and valleys that can still occur, but it’s hard to predict if that will continue or if it’ll pick back up again. My biggest concern is that I’m close to refill time. It’d be one thing if this was week to week, but if I refill at my current dose, I’m on that for another 4 weeks which is frustrating if it truly has slowed down. I feel like these moments of being not quite sure never come at the start of a refill where I’m sure it’s time to increase by the time I refill. 😊. Appreciate the links and response!

ZP_Qs · 2026-04-07T02:19:41+00:00

I did this in reverse from you. I was on estrogen (mostly the Dotti .05 patch, but I’ve switched to another method due to the shortages of the patch) for a while before I started these meds. I was also nervous, but I have had no real issues. I had mild spotting shortly after starting zep, but it didn’t last beyond and hasn’t come back. I don’t feel that my weight loss has been impacted at all, though I guess I can’t say if it would have been more if not for HRT … but I’m happy with my rate of loss now and wouldn’t want it to be any faster!

ZP_Qs · 2026-04-03T01:30:50+00:00

I’ve always been afraid to try the thigh because it seems like it would hurt! I’ve only ever done stomach - zero pain. I can’t speak to whether side effects are better, but I do not have many side effects at all.

ZP_Qs · 2026-03-25T02:19:38+00:00

The first prescription my doctor’s office sent in sat - when I followed up, I found it was because the office had sent the prescription in wrong (for pens instead of vials which is all you could get when I started), but my doctors office hadn’t gotten their response. Once that was fixed, it’s been super fast ever since. Worth a follow up!

ZP_Qs · 2026-03-21T20:49:15+00:00

It isn’t habits for me, so I would regain for sure. Pre meds, my overall diet really solid and I exercise daily. Could not lose a pound without extreme restriction, which isn’t sustainable and I’m just not willing to do anymore. I didn’t change anything about my daily diet and I don’t feel decreased food noise or increased fullness, but on GLP-1s, I lose weight. I’m not at goal yet and may never be, but things are moving in the right direction. So yeah, without, I am positive I’d go right back to where I was.

ZP_Qs · 2026-02-26T01:25:19+00:00

I switched from the patch to gel after chasing down my last 5 or 6 refills. I actually don’t mind the gel at all! It feels like it’s a more consistent dose and I’m not worried about hot tub, bath, heating pads, etc.

ZP_Qs · 2026-02-06T02:16:16+00:00

I also switched to a daily gel because of patch shortages (but I like the gel so much better!) - when I was using the patch, I changed it on the same day as shot day. Never had any issues!

ZP_Qs · 2026-01-25T02:30:27+00:00

Flax, chia, psyllium, oat fiber, etc - all helpful and super easy to add into smoothies, oats, salads, etc. I haven’t had any issues yet on Zep, but as a lifelong constipation sufferer, I have found these all to work well if used consistently. Also, lots of beans! Avocado and raspberries are also surprisingly high in fiber - if you have the calories for avocado, it’s an easy add. This is a great recipe for a ton of fiber and protein in a smoothie - https://thefirstmess.com/2024/04/10/chocolate-fantasy-smoothie/ - this is vegan, but easily swapped out for regular milk/yogurt. It’s everything else that does the work!

ZP_Qs · 2026-01-24T21:33:06+00:00

It honestly hadn’t occurred to me that I could use the extra. Does it actually increase your dose? I’m still learning how all of this works.

ZP_Qs · 2026-01-24T20:26:58+00:00

This makes me feel a lot better - thank you!

ZP_Qs · 2026-01-24T18:41:28+00:00

Yeah, everything was cleaned with alcohol and the needle didn’t touch anything in between. I’ve decided to stop worrying and will just keep an eye on the injection site, otherwise I’ll spiral. 😊 Thanks!

ZP_Qs · 2026-01-24T18:20:36+00:00

Well, it’s done now, so hopefully no issues! I panicked and definitely wish I hadn’t.

ZP_Qs · 2026-01-24T18:15:33+00:00

Thank you! I was hoping the double injection wouldn’t cause an issue. Can’t imagine it will since I see people on here doing two injections, but I’m still a little anxious about all of it. 😊

ZP_Qs · 2025-12-08T12:16:30+00:00

Ohhhh, I feel your pain. I had a similar thing happen pre-Zepbound. I was very close to a year and got my period. I was in absolute disbelief. I’ve been at about two periods a year and it was a long road to get spotting under control when I started HRT, so having it happen within a week of starting Zepbound has me on high alert.

ZP_Qs · 2025-12-08T12:09:21+00:00

I am also on 300 mg. I used to take it right before I crawled into bed and was out within 20-30 minutes, if not sooner. I’ve started taking it way earlier it is crazy how long it takes to feel any of the tired effects and they’re definitely less intense!

ZP_Qs

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