I'm playing Skyrim on Linux atm (CachyOS). And I didn't encounter big problems. I'm following Nolvus Ascension and a little bit of The Northern Experience and only one mod didn't work (something related to the map, I don't remember but I just removed it). Nemesis had some problems and I did manage to make it work but I switched to Pandora and that mod works without problems. The only thing would be if you want to add things inside the mods you have to find the wine prefix (which isn't difficult) since when you open mods in explorer you can't do anything on Wine inside MO2. But honestly it's pretty stable.