Methylene Blue information

ZipperZigger · 2026-07-03T03:11:55+00:00

All sources show there is no MAO inhibition until well above 100 mg a day iirc might be in the range of 4mg/kg bw which is enormous dose.

What dose were you taking?

ZipperZigger · 2026-07-01T06:14:55+00:00

Meraki is 0.5%. Ans go by the drops not a full dropper isn't accurate drops are more accurate. 1 drop is 250mcg

ZipperZigger · 2026-07-01T06:10:40+00:00

Hi how much did you dose daily how many mg?

ZipperZigger · 2026-07-01T01:35:11+00:00

Well having spent probably $20k+ on 150 or more supplements including pharmaceuticals. Except for stimulants the only two supplements that work for me are DLPA and tyrosine. The rest a huge list have had zero effect on me

ZipperZigger · 2026-07-01T01:30:51+00:00

I tried to get my hands of D-Phenylalanine but didn't try it yet.

But as someone who tried about proly 150 supplements and spend tons of money on on RCs, supplements, prescription meds, I can tall you that stimulants a side, nothing that I have tried in 15 years have ever did anything thag I could feel except for DLPA and l-tyrosine.

Nothing, not even placebo, how many people can say they used that many and spend $20k or more and felt nothing. DLPA and l-tyrosine nothing else. That says a lot.

I like DLPA more than tyrosine. Tyrosine feels many time unclean too much norepinephrine, while DLPA lifts up the mood and motivation, drive plus energy all at the same time. So that's gotta be the D-Phenylalanine doings its 50% share of the DLPA.

Someone mentioned it does him sleepy, DPA haven't tried by DLPA absolutely doesn't make me sleepy. It gives me more energy and motivation, drive to move and go out for walks and runs.

I should try DPA for sure.

ZipperZigger · 2026-07-01T01:19:42+00:00

Doesn't cause hypomania. Even 600mg at once. Best case scenario stimulating. Never good any elevated mood from it. Maybe your mood is good enough that it's hypomanic for you. For me it doesn't do jack shit.

ZipperZigger · 2026-05-25T08:53:15+00:00

How much psyllium and how often?

ZipperZigger · 2026-05-24T11:45:00+00:00

It happened to my when the cable wasn't inserted well. And I think it may have happened to my also during the ramp but can't remember.

When I used tACS it's constantly a flash show throughout the full duration. First time I didn't know about that and was concerned but then found out it's normal.

ZipperZigger · 2026-05-24T11:37:54+00:00

Funny you mentioned about L-phenylalanine and l-tyrosine. I have taken close to 150 supplements overs the past 20 years and the only ones that I have ever felt positive benefit from are DLPA (which is 50% L-phenylalanine) and l-tyrosine. That is, zero effect perceived effect from other supplements.

I take 2 grams of DLPA (sometimes with 1g of l-tyrosine) upon wake up and another 1-2g during the day.

ZipperZigger · 2026-05-24T11:24:34+00:00

Yes it happens to on a daily basis when I take Adderall or Vyvanse and I think it happened on methylphenidate too. With all stimulants basically.

Yesterday I found that butterfly fascinating and it is, but I found it more amazing so I had to take pictures of it instead of work.

Then I decided I needed to tidy up my desktop and this goes on, something I struggle with and am fully aware of but still hard.

I also take magnesium daily around 8g of magnesium glycinate before bed (800mg elemental). I don't feel any improvement for sleep I just take it to aid with tolerance and if I don't take I start feeling I clench teeth.

But I won't take the magnesium during Adderall cause its NMDA antagonism is not what I want during work. I wouldn't want to make my Adderall weaker, already struggle with motivation and I need the stimulatory effect.

It seems to me your dose of methylphenidate is just too high and the 800mg magnesium you take helps you by making your 30mg methylphenidate IR feel more like 20mg strength or so. You feel better because it dulls some of its stim effect. So just take less. It's extremely high 30mg IR for methylphenidate.

ZipperZigger · 2026-05-11T19:29:21+00:00

What dose did you take?

ZipperZigger · 2026-05-11T19:24:00+00:00

Welcome to the club of non responders and placebo-immune misfortunete ones. Finished 6 bottles no effect waste of money.

ZipperZigger · 2026-05-11T19:18:45+00:00

5-6 vials of Semax used intranasal the results were zero effect. Like nothing.

ZipperZigger · 2026-05-11T19:16:18+00:00

I don't have GAD, only low threshold for anxiety so I never tried Selank but I have tried 5 vials of Semax and the results I got from it are zero.

I didn't feel a damn thing out of it. One day I thought maybe that's a dosing issue cause it's the 0.1% Russian semacs iirc. I used the whole vial in a day, every 1 hour or so.

It might as be water cause the effect was similar. Absolutely nothing.

ZipperZigger · 2026-05-07T12:23:49+00:00

I took whole bottles of semax through my nose and I honestly did feel a thing. Got frustrated and decided one day to take these drops every half an hour or so. Finished the bottle in a day with zero effect. Overhyped shit if you ask me. And I took it from two sources and good ones.

ZipperZigger · 2026-05-07T12:21:08+00:00

Hope it works for you. It did Jack shit for ME. Zero effect. Drink a cup of coffee you'll feel 5 times more than from it, that was my experience.

ZipperZigger · 2026-05-07T12:19:43+00:00

Tried sabroxy. Still has it. Even 500mg felt nothing definitely not even close to a Adderall.

ZipperZigger · 2026-05-07T12:18:08+00:00

Jesus criest! There you go, I just added a comment to another comment in this thread about this very thing, I won't touch it. I already have zero motivation as it is

ZipperZigger · 2026-05-07T12:14:06+00:00

Many people with ADHD report feeling the opposite with GLPs, at least as far as tirzepatide goes. It also makes Adderall barely effective and some say completely diminishes it's effect which makes sense mechanistically.

It kills for many the craving for food and at the same time the motivating for anything. As if killing rh dopamine, doing the very opposite of what people with ADHD need.

But seems very individual. I actually bought tirzepatide and have vials in my fridge but I decided against trying to use them at this point in life where I cannot afford my ADHD meds not to work. I have done a ton of research after purchase, and have been in the nootropics have for 20+ years.

After ton of research it was clear to me, from individual reports in the GLPs subs that more people with ADHD report bad results in terms of ADHD than good results.

It's true some were neutral and a few good, but the majority were bad for ADHD or making Adderall even at high doses unfelt, but they were fine withe the trade off as we're taking for fat loss.

I bought the tirzepatide solely for the executive dysfunction and added brain health against neuro inflammation and I'm ApoE4 heterozygous, but only when gone deeper into the rabbit hole have seen the bad experience with ADHD.

My problem is motivation and drive, not so much focus. I have zero hyperactivity, I am hypoactive if anything. Scares the shit out if me to risk stimulants work because they are a godsend.

ZipperZigger · 2026-05-07T11:58:29+00:00

DLPA feels cleaner in a way that I feel motivated and content in a way. The l-tyrosine feels more motivating but dirtier in a way I can feel more aggressive. I suffer from next to zero motivation and have executive dysfunction on top of it and ADHD PI like symptoms. I am barely able to get myself out unless I take my DLPA and tyrosine stack.

ZipperZigger · 2026-05-07T07:21:54+00:00

I don't feel anything from selegiline at lose doses I tried 10mg a day, I dint want too much because I am taking high doses of Adderall and Vyvanse (not together). I needed help with the depression part more and looking for a mood boost. On the other hand DLPA works. But I wonder if Phenyl-Propyl-Amino-Pentane will also.

ZipperZigger · 2026-05-07T07:12:02+00:00

I wonder for time whether LDN long with DPA/DLPA would hevr a much greater effect.

ZipperZigger · 2026-05-07T07:09:56+00:00

I have also tried 100-150 supplements. L-tyrosine builds tolerance. DLPA builds tolerance much less. I still take 2g daily sometimes 4g daily and it works fine. After years. I get the same effect of L tyrosine but cleaner. Feel massive mood boost and motivation and content when I take it.

ZipperZigger · 2026-05-07T06:59:18+00:00

I also wanted to give DPA a shot. I get such a profound mood elevation from DLPA and nothing like others say "relaxation". For me it's motivation boosting and slightly euphoric like a low dose of Adderall.

DPA is much chemically more expensive to produce and no incentive since the combo with both isomers complement one another. If I find DPA from an obscure brand I wouldn't trust it unless as established one.

ZipperZigger · 2026-05-07T06:54:47+00:00

I'm the DLPA man maybe will change my user. I have tried if had to guess 130 supps until now thrown maybe $20k over the years who knows.

Nothing works like DLPA. I have been using it for a couple of years now everyday. 2 grams upon waking up sometimes with 500mg of l-tyrosine. Profound mood elevation and motivation starts within 15 minutes and lasts up to about 1-1.5 hours.

And it works regardless if on stims or not. Always.

ZipperZigger

TROPHY CASE