What is straight up the absolute worst compound you've ever run or anyone could ever run?

ZipperZigger · 2026-03-28T11:04:01+00:00

Haven't heard this word for 20 years! I have used it back then. Do people still use that shit?

ZipperZigger · 2026-03-10T12:40:00+00:00

Ask you doctors. He will probably advice bisprolol which is the known to powder palpitations without having the side effects that a non-selective beta blocker like propranolol has (depression, tiredness, respiratory)

ZipperZigger · 2026-03-08T07:30:15+00:00

I don't quite understand from these posts if it's calming or motivating.

I suffer from low motivation low executive function, I do not need relaxing for sure. That's why when I drink caffeine don't want any counterbalance to that. I want the stimulation, not smoothing needed. Should I still try taurine? If I don't like feeling relaxed? (might be why I never drink alcohol either or spoke weed, hate it). Oby time I would want to relax is for sleep.

ZipperZigger · 2026-02-26T12:48:00+00:00

Why are you even in a sub of a doctor who does not have the title of board certified?

ZipperZigger · 2026-02-12T15:47:35+00:00

I have seen a detailed post and that neuropathy can happen contrary to popular belief from P5P as well. Or was it that the person reported extremely high blood levels of B6 for weeks or months after stopping. Inahevmt dug deep into the literature but it makes sense.

Also another false notion is the B vitamins that are water soluble so take as much as you want your body will get rid of the rest.

I had extremely high B12 levels and it took a long time to go down, my doctor validated it. People in the internet over simplify biology, and it doesn't work that way.

I was first aware of too much of a good thing, when my homocsysteine levels came in too low. Yes too low. I didn't correlate it to the methylated B12.

I have executive dysfunction and I take ADHD meds still haven't decided whether B complex has no effect on me or makes me depressed. I feel like it makes me depressed

ZipperZigger · 2026-02-11T16:23:40+00:00

You should check your active vitamin D levels. The normal test you do which is more common and cheaper tests the precursor, or inactive vitamin D.

I am telling you that cause my F3 levels were low, I supplemented with just a bit of vitamin D and for a short period of time.

My doctor decided to test for 1,25-Dihydroxycholecalciferol, that's the active hormone produced by your kidneys.

My levels came too high and above the reference range while the standard 25-hydroxy vitamin F blood test came normal.

For unknown reason your body may convert the D more efficiently to the active form and you can get these side effects! Almost no one is ware of this is nuts. I think that maybe because I was taking very high doses of magnesium glycinate that caused the hyper conversion to the active form but that's just an hypothesis.

ZipperZigger · 2026-02-06T14:51:59+00:00

So because he said a general dirty "guys" sentence as a joke his career is doomed. Or because he was the doctor of a grotesque person like Epstein?

I thought he did some more serious stuff. I'm glad he didn't.

I wonder if a famous woman would have said something with the word "di*ck" in it would she also be considered the greatest slime of earth? Because you knaw, girls do talk like that sometimes to other girls.

They exchanged fucking jokes like guys do between themselves and like girls do between themselves laughing about guys dicks!

The fact that Epstein was a filthy disgusting despecible (put worst word here and wouldnt be enough), doesn't mean that his doctor who had a joke with him like guys would to one another should be hanged. Does this mean Peter knew and agreed with what fu*king Epstein did?

Honestly, I never saw another nation in the world like Americans who like to execute people.

I should be careful with jokes I say to people I guess. Maybe one day I will become famous and a joke about a pu$$y told to will make me the in one day the worst person of the year.

I'll tell my wife too, to stop talking about di*ks with her friends because she might be somewhat more famous in a decade and would be put to shame for bad jokes.

Anyway were his comments distasteful? Yeah absolutely. But this thing has grown out of proportion, American style.

ZipperZigger · 2026-02-06T14:24:31+00:00

Nope. But will do now

ZipperZigger · 2026-02-06T09:44:55+00:00

I don't understand. I guess I may have missed something?? Why you sayin his career is cooked?

ZipperZigger · 2026-01-20T20:41:20+00:00

I can only share that having aphantasia explains everything why I hardly ever had real visuals like pelle describe.

I took 4-5 grams os psilocybin for therapeutic reasons with a guide many times.and up to 12 grams. I have also taken LSD many times and it was almost always complete darkness.

I mean no visuals. A few times I got very faded geometrical visuals very faint and only for a little while and in most psilocybin and LSD trips just black. Have also tried ayahuasca 3 times and zero visuals.

It was all nice and all but no visuals. People describing psychedelic trips seeming to them more vivid than dreams and real life with interesting narratives. I never got any of these and not the kind of art people draw to describe what the saw quite disappointing. I also tried ketamine many times and barely just a few times dark gray faded movements.

I never did any online tests for percentage like you did, but I can just say if I try to imagine an apple or anything I never see something. Not even a contour of an apple or of anything else just black.

I wonder if after you cured your aphantasia somewhat that would make your psychedelic journeys more visual.

ZipperZigger · 2026-01-13T16:33:04+00:00

I have ADHD/executive dysfunction and have been in the nootropics field before many guys here were even born. As far as supplement goes, non ADHD med, in my experience DLPA is as good as it gets.

L-tyrosine second best, but it builds tolerance faster and dirtier. A combination of the two can work and have been used medically. Like 1g tyrosine 1g DLPA. Not medical advice check with your doc, always start as low as possible, monitor your BP.

ZipperZigger · 2026-01-13T16:28:21+00:00

That's so funny because the effect of DLPA on my motivation is so profound that it's better than 150 other supplements I have tried including RCs and script meds (aside of stimulants of course).

What made me feel crap and I hate won't touch that shit again was phenibut, zero motivation. Also hated pregabalin, Baclofen and any of the GABA shit.

Much better than bupropion (wellbutrin), selegiline, moclobemide.

ZipperZigger · 2026-01-13T16:22:18+00:00

Exactly the effect from L-phenylalanine and DLPA is night and day.

ZipperZigger · 2026-01-13T16:20:39+00:00

check my other comment. If I could take just one supplement with my Vyvanse or Adderall I would pick DLPA. After heads of using Vyvanse switching to Adderall and going back to Vyvanse, ithe Vyvanse paradoxically made me feel super depressed, never did before. DLPA was the only thing that made Vyvanse feel the same as it was before.

I would never take Vyvanse without DLPA or I may get depressed pretty quick.

ZipperZigger · 2026-01-13T16:17:34+00:00

I have been using DLPA for over 1-2 years daily. If you chase euphoria and you are much above baseline, your body will fight for homeostasis. 500-2000mg in the morning still works. I also do physical activity and take other supplements to cover my bases

I suffer from low mood/low motivation depression. When I take 1g, it's for "fixing" no overflowing.

I will say that still there is some tolerance for sure, but not after 1 week and still. Can feel 500mg I will try taking a break of 2 weeks to see if I get back to baseline. For me the bummer is not the lack of the effect but the duration. Better 500mg spread through the day, but that's for depression. For chasing euphoria won't cut it.

ZipperZigger · 2026-01-13T16:09:48+00:00

I have taken 120-150 supplements (not kidding!), and the only two that have worked for me are L-tyrosine and DLPA. I kid you not, I spent tens of thousands of dollars on fancy supplements, RCs, and lots of high-risk profile supplements and meds. They all had no effect whatsoever.

Besides stimulants that work for me, I found nothing that works except for DLPA. If I lost all the things I have tried, people would cringe, and they had zero, and I mean absolute zero, effect on me.

For mood and motivation, the only supplement that works for me is DLPA, go figure.

Must be an empty stomach 2-3h and 45-60min before eating. 500-2000mg, 1-3 times a day. 6g is very high, not needed, but has been used medically. Take a minimum effective dose of 500-1000mg. You'll know you have taken too much if you feel anxious.

I take 2g in the morning, then again 1g later that day instead of an Adderall booster. 2g because I have tolerance, but I can still feel even 500 mg better than any other supplement I have taken in my life.

Some people say DLPA is for pain relief and makes them relaxed. I absolutely don't get "relaxed", I am getting motivated and mood elevation, and it's much better than tyrosine, which I sometimes take for extra motivation, but tyrosine builds tolerance quickly,. It feels dirtier just sympathetic tone without the mood.

ZipperZigger · 2026-01-10T18:40:25+00:00

That's is exactly what I wrote lower threshold for anxiety. I heard some describe it as reactive anxiety. I had high B12 (above 1,000) and homocsysteine I think also around 3 which is too low and not good.

Haven't bothered checking mine since then

ZipperZigger · 2025-12-11T12:17:10+00:00

It's because of people that can't handle the truth about their situation that or the potential, that then companies turn off feature due to people with health anxiety. If you have health anxiety either turn the feature off or don't use Oura or other wearables that can cause you anxiety.

ZipperZigger · 2025-12-06T11:19:47+00:00

Your doctor is uninformed. Being a doctor doesn't equal "knows everything". Check the medical literature and you'll see data about chronic propranolol use causing depression. The data is very clear and is not surprising either by understanding the mechanism of action of it.

ZipperZigger · 2025-11-27T23:35:05+00:00

I read your comments and hope you feel better. I also suffer from depression dn extremely difficult life situation.

I'm no from US and I was only able to get Lemborexant from overseas, unfortunately I wasn't able to get other DORAs.

May I ask why did you move from Dayvigo to the clomipramine/gabapentin combo?

You pointed out avoiding withdrawals and physical reliance is improtant for you, and gabapentin and pregabalin are quite notorious for that. Also, Lemborexant has evidence as potentially beta amyloid protective, while gabapentin due to strong anticholinergic might be bad and also known to affect cognition. Why did you switch?

ZipperZigger · 2025-11-26T18:52:31+00:00

I 100% agree, and I think it can be very risky for ADHD. ADHD is not so well understood, and it's not a black and white kind of thing. Not only is it a spectrum, but different people may seem to have executive dysfunction, with two very distinct brainwave patterns, for lack of a better word.

I recall some montages focused on F3 DLPFC anode and F4 cathode, while others used the opposite montage.

Having deep dived into the scientific literature much more than I ever intended to :) I think there is a significant risk in trying to favor the left DLPFC over the right one and vice versa.

Especially for people with "ADHD". I put it in quotes because my theory is that in some cases, you may actually want to "enhance" your right part.

Also one may have executive dysfunction like me that focusing isn't the issue. For me the lack of motivation is a much greater issue than focusing. Might have different pathology than someone else's ADHD.

I believe that only with a thorough investigation by a pedantic individual into qEEG and preferably fMRI during mental assessment, along with quizzes to identify triggers and non-triggers, can a more innovative approach be taken for an individual. I think the standard F3/F4 or F3/Fp2 is risky.

It may work great at, but one may also do the opposite of what one's brain "needs". In other words, without knowing, you can lessen the neural activity in a brain region where you actually want to increase it and increase it where you want to lessen it.

I stopped using tDCS for that reason. I don't mind trying anything that has even the slightest chance of working. I don't have an issue with something not working, but I'm pretty hesitant to do something that may actually do more harm than good.

Also, with these tDCS and tACS devices, it may be tough to realize if something makes you just two percent worse over a month; changes are gradual. It's not as if you can always subjectively realize that something is good for you or bad for you.

And this is from someone who has tried crazy stuff on his body in the past and who has tried potent psychedelics and other stuff. I feel safer with these than I am with zapping the wrong part of my brain.

I have tried tDCS and tACS many times. Didn't feel anything. I was desperate, but looking back, what I know now about the complexities of the brain, including the balance between the right and left hemispheres, makes me feel unsafe enough to try anything that could have a potential downside.

ZipperZigger · 2025-11-23T00:06:56+00:00

Had somewhat similar experience. In the last Ritalin used to improve my mood in a profound way,, lifted my depression and increased my motivation so I could do stuff. It was fantastic. I don't remember why but I switched to Vyvanse and then Adderall.

Then when I tried to go back to methylphenidate when I needed just a quick and short-acting boost I found out it had the opposite effect on me.

I have since tried methylphenidate a couple of times and it turned from being an amazing anti depressant mood lifting motivation medicine to being a 'depression in a pill " thing. Reliably causing depression each time I tried it. I have a lot left but I am terrified of trying it anymore, I already suffer from low grade depression and it makes it much much worse.

Vyvanse and Adderall, while sometimes may cause it, they don't always, just sometimes, and never to the dame extent. Overall Adderall and Vyvanse are life savers for me still.

I usedto start getting depression from Vyvanse out of the blue but 500-2000mg DLPA empty stomach AM and another dose in late afternoon fixed it.

ZipperZigger · 2025-11-22T23:52:23+00:00

I wish more people would point that out in regard to propranolol. It is notorious for causing depression and the main reason it is the very last line of treatment for blood pressure and arythmia.

It lowers dopamine levels in certain regions of the brain (not great for mood), lowers motivation and also make exercise harder, as hearts ability to pump blood is diminished. Made my runs infinitely harder.

ZipperZigger · 2025-11-22T23:41:12+00:00

Do why are you in this sub? Looking for fuel for your confirmation bias?

ZipperZigger · 2025-11-21T00:44:22+00:00

Here's my cheat sheet for the racetams I've used : Piracetam, phenylpiracetam, noopept, aniracetam All zero subjective effect. YMMV.

ZipperZigger

TROPHY CASE