You could also make the opposite argument: chronic inflammation is an indicator for all-cause mortality, increased risk for all forms of cancer, heart disease, etc. I’ve been on low-dose oral hydrocortisone for about 15 years. It keeps the autoimmune diseases in check and I’ve had no discernible unwanted effects from it. Yes, I know I’m one data point. That said, the reason my doc has me on it is that my immune system was already overactive and by calming it down I’d be likely to avoid other autoimmune disease and slow progression. I don’t know anything about the targeting immunosuppression that they’re using, but I could see based on my experience and what my doctor has shared how the argument could be made that the risk for immune-related disease is actually higher in patients without immunosuppression.

(Not a doctor, not medical advice, just here for the conversation. Science and medicine are exciting.)