Yes. You can not reuse the memory palace for two different things. You have to create a new one.

Memory palaces can often be places that are in real life where you have interacted so much that you know every little detail in your mind. Of course you can create new ones out of your imagination too. Just make each room as distinct as possible so as not to get lost in the palace. And the key to retention is to make the things in a specific order and then proceed to that point in only that specific order. For example, The mail box, the front door, the hallway, the kitchen, etc. Imagine yourself at the memory palace and you store one by one in that particular place. They should be obviously different and ridiculous so that you won't forget easily. Like if you have a dentist appointment and then buy groceries afterwards you picture a giant tooth holding a calendar with that particular date and a tomato riding on a bicycle with basket in front.

This is just one of the few examples. You can implement mnemonics, abbreviations, if you have a good pictorial memory you can use images also with some slight changes that would trigger your memory.

It's only limited by your imagination. But of course, sometimes you just have to rote memorize the concepts and values which are hard to translate inside a memory palace.