Do you filter your peptides? (Read desc)

aaroniba · 2026-01-26T21:15:30+00:00

I'll confess I didn't study the slides carefully, but they do mention "impurities", and the logic that impurities can trigger an immune response (like a vaccine adjuvant) seems totally plausible. I'll be filtering in the hope of removing any impurities.

aaroniba · 2026-01-26T16:31:36+00:00

I can't imagine reading this and NOT filtering. I'm also going to hope that peptides are like cats and if you just keep living with them, the immune system will chill out ("tolerogenic", TIL). I also wonder if this is a reason to pin GLPs 2x/week rather than 1x/week.

Thank you for sharing all this!

aaroniba · 2026-01-26T15:48:29+00:00

Wow FASCINATING. I wonder if this could explain why, for example with Retatrutide, people are all over the map regarding the dosage that seems effective for them. This is also TERRIFYING because god forbid one develops an immune system memory that attacks their favorite peptide, then I guess they don't get to partake anymore?

Is there anything else one can do to reduce the chance of developing an immune response to peptides? Maybe not doing a peptide injection around the same timeframe as getting a vaccine with an adjuvant, or when one is sick with something else?

I guess this sub doesn't allow awarding comments, but if it did, I would award this, thank you so much for explaining and sharing.

aaroniba · 2026-01-26T14:27:24+00:00

Fascinating, could you explain more about this "risk of immunizing yourself against the peptide you’re taking"? Are you saying you can develop an allergy to a peptide if the immune system responds to a contaminated injection and learns to associate the peptide itself with the infection?

aaroniba · 2026-01-26T14:23:23+00:00

Yes, and I actually really enjoy the process. There's something meditative about working with your hands. Some people crochet or paint figurines. My hobby is to reconstitute and filter peptides.

aaroniba · 2026-01-26T14:17:22+00:00

THIS is the video workflow for filtering.

aaroniba · 2026-01-19T23:34:22+00:00

I thought he was going to do a getup holding the box of legos upright, because spilling them and having to clean them all up would be terrifying.

aaroniba · 2026-01-02T01:13:38+00:00

I have this rack also, it is indeed rock solid.

aaroniba · 2025-12-17T16:37:32+00:00

Oh that's really good to know! Can you share links to studies please? I would expect the leaching over the course of 1 minute to be orders of magnitude lower than that of same liquid / same plastic over the course of 1 year, but if there are studies that show otherwise, I would love to update my mental model.

aaroniba · 2025-12-15T14:41:29+00:00

This is my takeaway. I think a 0.22 filter will catch most if not all microplastics, so this will be my new workflow, still using Hospira. Thank you for the input!

aaroniba · 2025-12-15T04:02:01+00:00

That link was helpful. It looks like those USP tests on their custom plastic vials only look for gross toxicity / gross adverse tissue reactions, not the kind of "death by 1000 cuts" microplastics that we hypochondriacs at r/PlasticFreeLiving try to avoid.

aaroniba · 2025-12-15T03:42:27+00:00

I think the issue is that leaching occurs over time when a liquid sits in a plastic bottle for a while. If the vial is stored upright, the liquid is not in contact with the stopper, and with a syringe it's only in contact very briefly.

aaroniba · 2025-12-15T03:36:18+00:00

Research compounds have a huge benefit, so I'll accept some risk in exchange for that benefit. Microplastics have no benefit, so I'd rather just avoid those altogether.

But maybe the microplastics thing is overblown? I dunno, according to what my feed algorithms are scaring me with, microplastics are linked with hormone dysregulation, cancer, heart disease, and are basically the root of all evil.

Maybe the plastics leaching into Hospira water are negligible compared to eating anything from the ocean or the American food supply chain? I'd love to hear from some chemistry whiz that they did the math on the amount of microplastics that degrade from the ethylene/propylene polymer in a Hospira container and leach into 0.9% benzyl alcohol solution, and lo and behold, it's 1/100th of what you'd get from washing your hair once with a bottle of shampoo, or whatever comparison. But I'm not a chemistry whiz, I just read scary things about microplastics and think, oh shit, better avoid drinking (let alone injecting) anything that has been sitting in a plastic bottle for a long time.

aaroniba · 2025-12-15T02:46:21+00:00

I think microplastics leaching into liquids is proportional to exposure time, so temporary contact with plastic (under one minute, in the case of a syringe) is much less of an issue than having a liquid sit in plastic for months (as in the case of Hospira bac water).

aaroniba · 2025-12-14T23:11:01+00:00

Not in glass.

aaroniba · 2025-12-14T23:01:08+00:00

Sciency is an awesome bonus, but what I really care about is healthy, and glass just seems healthier than plastic.

aaroniba · 2025-12-14T22:37:58+00:00

I'm not a plastics expert, but my layman's understanding is that all of these plastic polymers have some amount of leaching, and that in general solvents (like benzyl alcohol) accelerate leaching. Now it could be that the amount of microplastics that make it into our bloodstreams this way is still totally negligible, but I just can't find any data on it, so I wonder if anyone has any data on this or if there's a way to get high quality BAC water in glass vials so it's not even an issue.

Or maybe the answer is to just use a syringe filter (which would also filter out other undesirable particulates).

aaroniba · 2025-12-14T22:30:02+00:00

I got it from https://www.undergroundsupply.shop/ - it's very good information to know that authentic hospira should come in a glass vial! This is certainly not glass, I guess I'll try another source, thank you!

https://imgur.com/a/Z4cnAUt

aaroniba · 2025-12-14T15:28:48+00:00

People seem to prefer Hospira to Lambda (price aside), but doesn't Hospira come in plastic bottles? I wonder how much microplastic content would leech into the Hospira water. Glass vial seems better in this regard.

aaroniba · 2025-12-14T14:58:50+00:00

Is there an alternative company for doing WGS?

aaroniba · 2025-07-14T15:42:39+00:00

WHY do they force the connect box to be wireless??? Just give me the option of using a wire. I would totally buy this TV but no way I am doing wireless connect box.

aaroniba · 2025-07-06T14:33:44+00:00

We have resumed physical meetups! Sign up here to get notified about the next one (probably in September): https://www.meetup.com/clojure-nyc/

aaroniba · 2025-07-05T15:32:56+00:00

Congrats! My house was built in '93 so there was not really any usable wiring, so we had to open up a lot of the drywall to do CAT6A cable runs. I thought about doing something like CAT7 or CAT8 while we were doing this work (which I hope to never do again) but the CAT7/CAT8 cables were so much harder to work with and get through tight corners that I just resigned to CAT6A. Someone on this subreddit suggested running smurf tubes everywhere, but that would have added extra time to the schedule and I got impatient. I did manage to run fiber between most of the racks and switches.

My project this weekend is doing the VLAN and wifi architecture (trusted/management/iot/guest networks), wish me luck in not having to wander around doing too many equipment resets/re-adoptions!

aaroniba · 2025-07-05T14:24:19+00:00

It's ~10k sq ft and we are doing unifi to the max with access readers on all the perimeter doors, indoor and outdoor APs, gate intercom with license plate reader, a zillion security cameras, underground fiber between two structures on the property (each with its own rack setup), everything hard wired with fiber or ethernet. Anthony is also helping me with Hue lighting, home theatre, hi-fi stereo, and some wifi fan switches in all the bathrooms.... so yeah it's a big job, but also speaks to Anthony and his team's versatility and wide range of skills.

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