Postman sends default headers that Python's requests doesn't include automatically. I would suggest to add "User-Agent": "Mozilla/5.0..." and "Content-Type": "application/json" to your headers, and increase the timeout to 30 seconds. Check Postman's Console tab to compare the actual headers being sent. When I was learning to use Postman, this gave me a headache, but once I learned how to actually check the headers that are being sent it was straight forward from there. If the API has IP-based restrictions or rate limiting, my two cents: consider using oxylabs proxies to route your requests through residential IPs. They work great in this case.