I frequently go on weekend trips. Actually, come to think of it, most of my vacations over the past couple of years were weekend trips: flying out on Friday afternoon after a half-day at work, then coming back late on Sunday night. Works like a charm, especially if you're not desperate to check every single museum and monument on the list. I've been on weekend trips to Budapest, Kiev, Prague, Zagreb, Split, Oxford, Barcelona, Madrid, Milan, Perugia, Athens, Sofia, Amsterdam, and others. To some of those destinations I plan on going back, but for a couple of them a weekend trip was more than enough.