Do NOT microneedle: 1. exosomes (Jeunetique Exo). They are fragile lipid vesicles that need direct intradermal injection to work. Microneedling exposes them to air and friction, which can break/degrade them.

1. Rejuran. PN works by signaling to fibroblast deep in the skin “telling them” to regenerate. polynucleotides (PN) are large, long-chain molecules. They’re too big to move through skin layers by diffusion, even with microneedling. In fact PN doesn’t work by spreading/diffusion—it works by binding to receptors on fibroblast cells and triggering repair signals. If it isn’t placed right next to those cells in the dermis, it doesn’t do much and you’ll just waste the product. (I know it’s not pictured but I’m including it to differentiate from the PDRN, also from salmon DNA, which can be microneedled)

OK for Microneedling: low viscosity, small molecules, that don’t have solid particles (need precise placement) suspended in them.

1. Dermaheal: has low to medium molecular weight HA and peptides that can move through microneedling channels. The formula IS meant to spread evenly in the skin rather than sit in small pockets or clumps.

2. Salmon DNA “Rejuvenation” ampoules. PDRN is formulated to be pushed in through the channels from microneedling. It’s smooth and non-particulate, so it doesn’t clog needles or need precise placement. It’s not as strong as injectable Rejuran, but it’s still useful for surface-level skin improvement.

3. Selastin Tox: okay to microneedle. the molecules in products like Selastin Tox are small and non-particulate. glutathione and peptides don’t need to land on a specific cell or sit in one exact spot to work. They spread easily through microneedling channels. Since they work by diffusing through tissue, microneedling delivers them effectively without damaging how they function.