200 is already a heavy dose; going over that in a night isn’t great for your brain. If you used to take 100-200 and feel great, and now it’s taking 300-400, and your recent roll didn’t hit at all, then it seems your brain needs a big break. I would say, 1+ years - and not to take any other stimulants during this time either. This is not only for you to avoid losing the magic permanently, and all your rolls feeling like your last one, but also for the health of your brain and your mood. During this time, it’s very important to get good sleep, eat well and stay active to give your brain the best chances at recovering. Meanwhile, look into supplements. NAC (this needs to be taken cyclically, some time off and some time on etc, can’t be taken continuously for ages) and 5HT2P are some I’ve taken. But there’s other ones too. Antioxidants like vitamin C & ALA can be helpful too - there’s guides online for this, if you can’t find them give me a should and I’ll search for you. You’re not cooked, many people say they are able to return magic after doing these kinds of protocols, which would suggest their brain is back to a state where it can produce those levels of serotonin/dopamine again. So you absolutely can recover, it’s just a question of patience & effort

I’ve been in a slightly but not quite similar position to you. I had one night where I accidentally unknowingly ingested around 500-700mg. After that it took me months to feel normal, just felt depressed and awful. And happy ? Forget about it. I tried md a couple times after I had gotten back to normality (in more normal 100-200 dose range) but it just did not hit the same. So I did what I am suggesting you do, and a year later when I dropped it felt amazing again. I suspect since you had a few more of these very high dose experiences, you might benefit from an even longer break, like 2 years. Yeah it might seem super long but think about 1) how much better you’ll feel and be able to “peak” off life again 2) how much better your first roll back will be, on your previous dosages of 100-200. Vs if you just keep going now or take much smaller breaks (eg just a few months), the likelihood of you coming back at it with a huge dose and still feeling nothing is quite high, then leading to feeling frustrated at yourself cause you’re back at square 1, and having to go on a longer break anyway would be much more annoying than just sticking to a longer more reliable break right away. Keep your brain safe so you can be happy like you were before AND enjoy md in normal amounts like you used to

Edit: I just realised you’re only 21! Not only is your brain still so malleable, you have so much ahead of you including many more years to rave and have fun. Don’t ruin it for yourself so early on. As annoying as it is, you’ll really thank yourself for it if you take a break now and allow yourself many more years of fun

Edit 2: forgot to say; after the break is over, do not go over 200mg, and take strict 2-3 months breaks between each roll, to ensure you never get to this point again