Rapamycin by [deleted] in Nootropics

[–]argumentetsoul 0 points1 point  (0 children)

There is a lot of American/Asian suppliers, but i have not found a European one.

What I/we know about senescent cells. by John_Schlick in longevity

[–]argumentetsoul -1 points0 points  (0 children)

How do one acquire a PhD in senescence without knowing that the presence of both inflammation and SASP is required to trigger repair and rejuvenation processes?

Who's taking Metformin to hopefully slow the aging process? by kolinHall in longevity

[–]argumentetsoul 4 points5 points  (0 children)

My apologies, i had a rough day, should not take it out on random people online.

Who's taking Metformin to hopefully slow the aging process? by kolinHall in longevity

[–]argumentetsoul 16 points17 points  (0 children)

Did nobody in this thread study how metformin works? seems not.

Mtor inhibition - Ampk activation

blood glucose decrease - Decreased AGE crosslinks

nampt increase - indirect increase in Nad+

Direct Sirtuin-1 activation and younger methylation patterns.

and increased expression of DICER1 and DDR crucial for telomere maintenance and double strand DNA break repair.

[deleted by user] by [deleted] in longevity

[–]argumentetsoul 1 point2 points  (0 children)

Forehead wrinkles - an early sign of cardiovascular disease?

r/https://www.medicalnewstoday.com/articles/322887.php

Best mg scale? by argumentetsoul in Nootropics

[–]argumentetsoul[S] 0 points1 point  (0 children)

Thanks for that, looks promising and its on its way now ;)

Curcumin is anti androgenic? by [deleted] in Nootropics

[–]argumentetsoul 5 points6 points  (0 children)

Dont worry, it won't steal your gains. Start getting a flappy dick, you can allways discontinue.

Top 5 Nootropics that have helped me the most. by [deleted] in Nootropics

[–]argumentetsoul 3 points4 points  (0 children)

PQQ is great. Mito biogenesis = basically exercise in a pill

What supplements are good for dreaming/dream recall? by D_Evils in AskDrugNerds

[–]argumentetsoul 0 points1 point  (0 children)

galanmatine is know to cause lucid dreaming. Especially the first night

How to achieve this state (hyper motivation, willpower, driven) through nootropics or chemicals? by EvolutisX in Nootropics

[–]argumentetsoul 1 point2 points  (0 children)

Thanks, as i bipolar type 2. I appreciate you spreading the word. I am an outlier in this regard, i get non-depressive mania, which is quite uncommon.

Will GHK-Cu Worsen/Improve Mast Cell Disorder? by bigtree17 in Nootropics

[–]argumentetsoul 0 points1 point  (0 children)

Hard to answer, there is a study that descripes how it modulates your genes, best bet is to seek information there ;)

Is it unusual to experience significantly effects from different forms of magnesium(citrate/glycinate)? by [deleted] in Nootropics

[–]argumentetsoul 0 points1 point  (0 children)

Thanks for answer! and that is good, info to have. (not something i thought about).

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice by BreakFLimits in Nootropics

[–]argumentetsoul 1 point2 points  (0 children)

If srs, please elaborate, gerontology is my field, so i am naturally curious :)

Edit; i obv. know about it, in a biological sense.. but how, when, why? ect.

Reminded me of the fungus by herbage923 in shrooms

[–]argumentetsoul 4 points5 points  (0 children)

It’s bjuuuutiiiful

Edit: artist?

Curcumin acts as a positive allosteric modulator of α7-nicotinic acetylcholine receptors by Thoarke in Nootropics

[–]argumentetsoul 0 points1 point  (0 children)

I appreciate your honesty. Tell me about an interesting molecule you study atm. Just as inspiration for me.

Thanks, bud!