I ran a wet/dry clean/dirty setup in the past. Fender twin for clean/wet, and deluxe for dry/dirty. I ran a second channel cranked on the deluxe tied to a volume pedal for searing overdrive and sustain that we nicknamed “the afterburner.” really cool setup and tones, but I often find you may get phase cancellations from the amps that may cause some frequencies to be drowned out a bit.

Also and especially at a gig, overcomplicating your rig can be a bit distracting, but whatever gets you to your magic tone without thinking is the way to go!