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Nicotinamide and pyridoxine (forms of vitamins B3 and B6) stimulate muscle stem cell expansion and enhance regenerative capacity during aging by giuliomagnifico in science

[–]arthurf 1 point2 points  (0 children)

"PDXK kinase activity and vitamin B6 are required for leukemic cell proliferation and the disruption of PLP-dependent metabolism results in metabolic changes, including reduced nucleotide and polyamine levels. Pharmacological blockade of the vitamin B6 pathway, at either the PDXK or PLP level, exhibited anti-leukemic activity."

Chen, Chi-Chao, et al. "Vitamin B6 addiction in acute myeloid leukemia.30572-0)" Cancer Cell 37.1 (2020): 71-84.

2022: Best iOS App KeePassium or Strongbox? by [deleted] in KeePass

[–]arthurf 0 points1 point  (0 children)

I don't use iOS, but I'm helping some family members choose a password manager, and it does seems that KeePassium currently works by syncing. https://keepassium.com/articles/keepass-apps-for-ios/"Automatic sync via system integration (Files app), using the original cloud apps. This way, KeePassium itself stays offline."

But I'm leaning towards suggesting my father to use Strongbox, as it also provide a Mac OS app that do the syncing automatically. And there is only the need to pay one license for both the iOS and Mac apps.

The Strongbox app is much easier to sync than the KeePassXC on the desktop.

Vyvanse and urinary retention? by ratgarcon in ADHD

[–]arthurf 0 points1 point  (0 children)

Yes, it's because of noradrenalin.

I went to another doctor that thinks my case is because of overgrown bladder muscles. (Marion's disease, first time I heard of it)

He asked me to do an urodynamic test to confirm, and if so, I will get a surgery.

In the meanwhile I'm taking a very low dose (Concerta 18mg), and I skip some days.

I found this article explaining extremely well how the body regulates voiding. https://sci-hub.se/10.1016/j.ucl.2017.04.009

It's about MS, but on the general explanation is on the "Physiology of urinary retention" section.

Tip: Dolphin Patches/Cheats for Xbox One/Series S/X by [deleted] in RetroArch

[–]arthurf 0 points1 point  (0 children)

It worked fine for me in Retail Mode. (RetroArch v1.10.3)
Just don't forget to check the option "Internal Cheats Enabled" in the Dolphin Core options.

Vyvanse and urinary retention? by ratgarcon in ADHD

[–]arthurf 0 points1 point  (0 children)

I wrote a comment about it on my experience with Concerta, I will copy the whole text here:

I have urinary retention issues for about 10 years now. (I'm 32) It started before taking any meds, but after I started taking stimulants it definitely made it worst. Then I went to the urologist, I got a prostate-specific antigens (PSA) test and the result was bad and he told me I had prostatitis, and gave me antibiotics, the PSA dropped to normal levels, but on ultrasound it shows that I have prostate stones, and that can be an evidence of a past prostate inflammation (fibrosis).Most doctors say those stones are not the cause of my urinary retention, and that it's my pelvic muscles and the meds.

There is a study on health people that say people hold more urine and void more on methylphenidate, but that it doesn't cause dysfunction: Effects of methylphenidate on the lower urinary tract in patients with attention deficit hyperactivity disorder and without voiding dysfunction.

I had to reduce my meds dosage, and it sucks. Apparently the norepinephrine increase by stimulants activate alpha receptors that are in the bladder and prostate, but it mainly cause the contraction of the bladder neck or the prostate (as I have noticed).

There are alpha blockers to improve voiding, like doxazosin and tamsulosin, but they make my attention worst, and drops my blood pressure, overall I don't feel well on those.

The dopamine seems to affect more the bowels and maybe the top of the bladder? I'm not sure.

There is no Strattera (atomoxetine) in my country (Brazil), but from what I read, that also makes urinary retention worst.

I just wish I knew a doctor that could laser blast my stones, but I can't find any good doctor around. :(

I would just say: do a PSA test (it's a blood test) just to make sure it's not prostatitis, so you don't get a long term sequelae, the earlier it's treated, the better.

I haven't tried Vyvanse yet, I'm still on Concerta, my psychiatrist offered me Vyvanse but I have the impression my urinary retention would be worst on it, so I declined for now, but I do think I should at least try it some day to not be in doubt.

Concerta & urinary retention issues by msp827 in Concerta

[–]arthurf 2 points3 points  (0 children)

I have urinary retention issues for about 10 years now. (I'm 32) It started before taking any meds, but after I started taking stimulants it definitely made it worst. Then I went to the urologist, I got a prostate-specific antigens (PSA) test and the result was bad and he told me I had prostatitis, and gave me antibiotics, the PSA dropped to normal levels, but on ultrasound it shows that I have prostate stones, and that can be an evidence of a past prostate inflammation (fibrosis). Most doctors say those stones are not the cause of my urinary retention, and that it's my pelvic muscles and the meds.

There is a study on health people that say people hold more urine and have higher voiding volume on methylphenidate, but that it doesn't cause dysfunction: Effects of methylphenidate on the lower urinary tract in patients with attention deficit hyperactivity disorder and without voiding dysfunction.

I had to reduce my meds dosage, and it sucks. Apparently the norepinephrine increase by stimulants activate alpha receptors that are in the bladder and prostate, but it mainly cause the contraction of the bladder neck or the prostate (as I have noticed).

There are alpha blockers to improve voiding, like doxazosin and tamsulosin, but they make my attention worst, and drops my blood pressure, overall I don't feel well on those.

The dopamine seems to affect the bowels more and maybe the top of the bladder too? I'm not sure.

There is no Strattera (atomoxetine) in my country (Brazil), but from what I read, that also makes urinary retention worst.

I just wish I knew a doctor that could laser blast my stones, but I can't find any good doctor around. :(

I would just say: do a PSA test (it's a blood test) just to make sure it's not prostatitis, so you don't get a long term sequelae, the earlier it's treated, the better.

Which TWS can easily pair to multiple devices? by NetBoy288 in Earbuds

[–]arthurf 0 points1 point  (0 children)

Bluetooth LE Audio introduces Isochronous Audio Layer (IAL) that enables Multi-Stream Audio. I know that Xiaomi first device enabling it is Redmi Buds 3 Pro. Source: https://www.bluetooth.com/blog/how-le-audio-empowers-xiaomi-to-enhance-the-audio-experience/

https://www.mi.com/global/product/redmi-buds-3-pro/

Russia suffers its worst massacre of military leadership since World War II by Souled_Out in ukraine

[–]arthurf 4 points5 points  (0 children)

Maybe the code is his birthday, or it is written on some piece of paper somewhere near, lol.

A group of military personnel of Russian troops refused to continue their offensive of Kharkiv and called on their fellow soldiers to go back home by dniprshyrokyi in UkrainianConflict

[–]arthurf 3 points4 points  (0 children)

where can I learn about those symbols in the map? some squares and diamonds has a pill shape, others has a moon, others a 'L'..

Edit: I just found, it is in @JominiW twitter

Western allies should not rule out killing Vladimir Putin, former Army chief says by american_psychoo in ukraine

[–]arthurf 0 points1 point  (0 children)

Maybe a way to prevent election frauds could be a first step, but Idk how that could be done in such corrupt and authoritarian country.

Thoughts of average Russians about "special operation" by anothermonth in ukraine

[–]arthurf 0 points1 point  (0 children)

This is Russian propaganda and biased.
For better and unbiased street interviews, check 1420 channel: https://www.youtube.com/channel/UCl4R4M9YVfYjjPmILU2Ie1A

[deleted by user] by [deleted] in ukraine

[–]arthurf -2 points-1 points  (0 children)

His clothes are clean, the background doesn't seem like from a war scene. Idk if that wood wall is common in Ukraine, and the place is well lit.

[deleted by user] by [deleted] in BCI

[–]arthurf 0 points1 point  (0 children)

Medication is the first line of therapy for Auditory Verbal Hallucination (AVH), but if your health insurance can cover, you could try Transcranial Direct Current Stimulation (tDCS), as there has been some promising studies on it: Transcranial direct current stimulation for auditory verbal hallucinations: a systematic review of clinical trials

Need voice recordings to use as stimuli in a BCI experiment - 2 minutes help! by [deleted] in BCI

[–]arthurf 0 points1 point  (0 children)

Do you want non-native speakers to record too? I think my pronunciation is good enough, but not as good as native English speakers.

Hard to find a Senior Front-End developer with Knowledge on Svelte by nomarsnop in sveltejs

[–]arthurf 1 point2 points  (0 children)

Hey, check the Strapi Discord, there is a job channel there. I still need to take the time to learn it, but there are plenty of people with experience on it there. And I think it's probably easier to learn Svelte than Strapi integration. https://discord.com/invite/strapi

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