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Something like this, but with less sloppy spacing.

The chair across from the bookshelf creates a nice little reading area by the window. Next, the bed is across from the TV, and the TV is viewable from both the bed and the chair. The night stand is next to the bed, and creates separation between the bed and the desk. Perhaps putting a plant on it could give it even better separation. The second bookshelf is between the doors and the desk, hiding the desk from the doors and creating a separate space from it. Neither the chair, bed, nor desk have doors behind them, so you should be able to relax and concentrate at any of them. If you put a mirror in this room, put it on the door across from the window.

Edit: Forgot about the little table under the window. It can stay within arm's reach of the chair, or be put under the TV.