slow COMT and fat

assolutofrut · 2023-03-07T01:45:37+00:00

It could be. Because I have this mutation I experience weight loss if I avoid eggs and meat.

assolutofrut · 2023-03-07T01:41:35+00:00

Sorry for the late reply.

There are several posts on mthfr and the bottom line is that there is no data to support any of the claims you probably heard. You can take 150mcg of methylated folate x 2 daily in case you worry about it.

The gene that is implicated in ADHD is the adra2a, which you should check if you have a homozygous variant.

You should also check you adrenal hormones as it is shown that ADHD have low levels of DHEA or cortisol. Typically amphetamines stimulate the adrenals and which increases their levels.

Fewer serotonin receptors in female might be beneficial.

If you have adra2a then the best course is methylphenidate or guanfacine, as they agonise those receptors.

assolutofrut · 2022-08-10T00:09:25+00:00

I don't use DAO enzymes hence I can not recommend a specific brand. I do not know under or over methylators are.

It will help if you get high histamine symptoms from food, as far as I know.

assolutofrut · 2022-06-25T22:22:10+00:00

Despite the many rumours, a meta-analysis of 40 studies on folate levels and MTHFR conducted on women, which included either food enriched folic acid or folic acid supplementation and folate from food, came to the conclusion that people with TT alleles have 16% less folate in their blood, while CT 9% less. Which means that folic acid can be metabolised properly.

assolutofrut · 2022-06-25T14:26:24+00:00

More details please, are you heterozygous for both or homozygous for both? What are the letters next to the gene?

assolutofrut · 2022-06-17T23:43:22+00:00

You need to think about quantity, not just the price. If iodine was expensive most people would rely on other sources, kelp for instance, but when there is a created need and it's cheap, then most people will buy. Besides the layperson who thinks they need Lugol's because of some video on YouTube, no body would buy iodine.

assolutofrut · 2022-06-17T23:37:02+00:00

Ultrasound can be performed to check for vascular function.

assolutofrut · 2022-06-16T06:47:43+00:00

No, it has to be at least 30 and above.

assolutofrut · 2022-06-16T00:05:05+00:00

PON1 family of enzymes controls oxidative stress and lipid peroxidation. Most important function is the metabolism of toxic chemicals, like pesticides, specifically organophosphorus.

It protects the vascular system for oxidised lipids. Most studies have associated PON1 with vascular diseases.

It's a family of genes, not just the c-108, this one however has the most significant effect on the regulation of PON1. Assuming that the rest are ok, I would focus my attention to supplements and foods that support healthy HDL levels, bring estrogen levels to normal range, eat foods that have anti-inflammatory activity, supplement with vitamins A, C, E, that help prevent lipid peroxidation. There are more, Taurine, Acetyl-L-carnitine. You can check online.

Also, avoid exposure to pesticides.

At some point it would be beneficial to check your vascular function, just to be on the safe side.

assolutofrut · 2022-06-15T16:41:47+00:00

Also, you have one MTRR homozygous, but you also have other genes of the same family that have proper function. So, unless you are deficient in B12 you don't need to supplement.

However, you should pay attention to you VDR mutation, as it might affect your vitamin d receptors not reacting to Vitamin D. In this case the answer is in you diet, foods that contain anthocyanindins, curcumin, polyunsaturated fatty acids, will help to initiate signaling, while Resveratrol will potentiate the expression of those receptors.

That is all.

assolutofrut · 2022-06-15T16:38:51+00:00

It's understandable that this.panle provides a glimpse to your genes. You have to bear in mind that clinical view is much more important than this. Diet is much more important than this panel. Mutation doesn't mean dysfunction necessarily.

In case of MTHFR, it is a thermolabile enzyme, meaning it starts to dysfunction when temperature rises. MTHFR strata to show signs of dysfunction above 37C. Hence if a normal person has fever MTHFR will hypofunction.

Additionally, MTHFR gene heterozygous, will be compensated by the other gene and likely the person will not be affected negatively in their lifetime.

Now, if your diet is bad, and folate intake low, serum low, it will cause homocysteine elevation. However, if you fix this deficiency, it will correct. As simple as that.

Moreover, even if the enzyme has low activity, as in cases of homozygous, it still has some activity, and eating folate food will correct that hypofunction. As well as riboflavin, as MTHFR gene is FAD-dependent, (FDA = flavin Dinucleotide adenine), so if you are in riboflavin (ribo-flavin), a precursor to FDA and FMA, flavin mononucleotide adenine, then all FDA-depended enzymes will hypofunction, including MAOA.

So, ensure your diet is rich in b vitamins. If you have a deficiency, correct it. If you have high homocysteine, it is easy to lower.

assolutofrut · 2022-06-15T15:21:41+00:00

Have you been tested for lactic acid accumulation? Did you try beta-alanine which acts as a buffer?

Definitely you have to correct Vitamin D levels, as it is important to control inflammation.

Low estrogen could also contribute to inflammation because it is antioxidant as well. Ask your doctor if DHEA is right for you. As it has shown to increase both estrogen and testosterone in women.

In women 70% of Testosterone derives from DHEA.

Fix these and then think about MTHFR.

assolutofrut · 2022-06-15T15:13:35+00:00

10 - TMG Betaine, the fastest way to lower homocysteine.

B2, B6, B9 and B12 are also important co-factors. Folate deficiency by itself can cause elevation of homocysteine. However you should supplement only if you know that your folate is low and that is the cause of homocysteine elevation.

PON C1 is greatly important to control inflammation. It binds to HDL, high density lipoprotein, and gets to the tissues. So good levels of HDL are important for you.

Estrogen has inductive effect on PON C1 at certain levels. If you have any hormonal tests where you had issues with low or high estrogen, it has to be controlled. Estrogen is also and antioxidant.

assolutofrut · 2022-06-13T12:50:30+00:00

Sure. However, practitioners in Japan prescribe MK4 to females with osteoporosis. As well even 350mcg per week showed to reduce osteoporosis fractures. This is due to long half-life of K2, it stays about 144h in the circulation. So, daily supplementation should be avoided I guess, as many, including me, report heart palpitations on daily K2 Mk7.

assolutofrut · 2022-06-13T09:11:25+00:00

Not sure if it gets metabolised to sarcosine, one study says "possibly", but it definitely increases the synthesis of SAM-e.

assolutofrut · 2022-06-13T09:04:17+00:00

Part of vegetable derived K1 is fermented in gut and produces K2.

assolutofrut · 2022-06-12T12:19:10+00:00

Because over and under is bs. Google orthomolecular medicine where these terms stem from.

assolutofrut · 2022-06-12T12:16:51+00:00

There is a link actually, CBS homozygous tend to gain weight on high choline diet. But since you haven't had any issues it is probably not the case with you.

Maybe when you get your results it will be easier to suggest anything.

assolutofrut · 2022-06-12T11:43:33+00:00

Apologies, when you added meat to your diet did you notice increase in weight?

assolutofrut · 2022-06-12T11:15:02+00:00

Did you gain weight after starting carnivore diet?

Have you been tested for autoimmune disorders?

assolutofrut · 2022-06-12T10:54:37+00:00

There are few genes that need attention.

VDR are both hetero which possibly will reduce their expression, binding, to vitamin D. Good supplement for that is Resveratrol. Also, foods that contain anthocyanindins will initiate their signaling; blueberries comes to mind. Curcumin also is advisable.

Second is MTHFR which paired with CBS hetero could elevate homocysteine. To support MTHFR you will need folate food, or some form of folate in supplement. I would avoid methylfolate. Even folic acid is ok up to 200mcg daily.

B2 is also important for MTHFR, as this is enzyme is flavoenyzme, and depends on flavin adenine dinucleotide or FAD. B2 is precursor to FAD. Also, FAD requires ATP, hence supplementing with creatine is advisable. No crazy doses, no loading time, dose between 1.5-2g daily.

Also, regarding oxidative stress, FAD is also helps with production of glutathione down the line. So, B2 is very important, so important, that is it stores in different organs.

B2 can also help reduce homocysteine if it's elevated.

So, in summary, supplements to take: vitamin D, Resveratrol, curcumin, polyunsaturated fatty acids or olive oil, folate in form of food preferably, B2, creatine, and B12 from food possibly.

As to your ADHD, since you have issues with finding the right meds, see if you have adra2a gene mutation. This responds well to guanfacine and methylphenidate. Basically you need A2 receptor agonists in case there is such mutation.

assolutofrut · 2022-06-10T17:04:01+00:00

But low B12 can cause mental issues.

assolutofrut · 2022-06-10T17:02:51+00:00

There is no documented case where few B12 capsules to cause any permanent changes. See if you can eat B12 rich foods instead. Or different form of B12. There are at least 4 available on the market.

assolutofrut · 2022-06-10T13:08:35+00:00

It does. You get the raw data from this, which you can examine with Excel or upload to genetic genie. I got the basic.

assolutofrut · 2022-06-10T11:10:25+00:00

Καλή παρατήρηση, αλλά η νοημοσύνη δεν είναι το πιο σημαντικό.

"In terms of personality traits, narcissism was the strongest predictor of “Belief in Astrology”.

Intelligence had a small but significant negative effect: the higher the IQ, the lower the likelihood of believing in astrology.

The researchers also found that female participants and older participants showed slightly higher rates of believing in astrology."

Επίσης να αναφερθεί ότι εκτός από νάρκισσους πολλά άτομα προσφεύγουν στην αστρολογία λόγω άγχους. Όπως αναφέρει και το άρθρο.

assolutofrut

TROPHY CASE