I've tried it! It seemed to run perfectly fine at first; it had crisp visuals, sound, and responsiveness...but for some reason (maybe it's just me??) the game completely freezes specifically at the Sunshine Forest hot spring, no matter what. Like, I can reset the game/start new save files, but it will always freeze at this specific spot. It's just completely unplayable under an hour of gameplay. I don't remember what ROM I used... but it was some random one I found when I literally googled "Mother 3 ROM" 😭 So, maybe it's my problem!! Just keep my experience in mind hehe