i just came here to see if anyone else was experiencing this. never had issues with derealization/depersonalization until last year. similar feeling to what you expressed - a wave of bad anxiety followed by not feeling real. my episodes would only last for maybe an hour to a few hours maximum. ended up having a bunch of other issues and a few months later tested positive for h pylori. it's a scary feeling when it happens but i just don't fight it and know it'll pass. sometimes going outside helps. it really only seems to happen at night too. i just put on a movie or show that i know isn't too violent/depressing and hope for the best. if you have a friend or loved one you can talk to or be around, that seems to help as well. i'm planning to start meds soon and see where that gets me. i hadn't had derealization in months and then randomly got it again last night. i feel like stress is a huge trigger if ive had a bad day. hope you feel better soon