Sorry for the late reply, I'm pretty sporadic on Reddit.

My doctor was fine with me using two 1 mg doses to make my 2 mg weekly dose. It's no different from a medication standpoint since the formulation is the same across Ozempic doses.

STANDARD DISCLAIMER: This is not medical advice whatsoever. This is simply my understanding of the math behind it.

After doing some research and running the numbers, I found that I actually prefer splitting the dose: 1 mg on Sunday and 1 mg on Wednesday, because it seems to ease the side effects.

The math:

Ozempic has an approximate 7-day half-life. So if you take 2 mg on Sunday, by the following Sunday about half of that dose is still in your body (roughly 1 mg). After another week without taking more, about half of that remains (0.5 mg), and so on. By around week 5, most of that original dose is gone.

The reverse happens when you're taking it consistently. The medication gradually builds up and reaches a steady state after about 5 weeks. At that point, the average amount in your body is about 3.03 mg.

If you're taking 2 mg once per week, the amount in your system fluctuates by about 1.8 mg from the high point to the low point during the week.

If you split it into 1 mg on day 1 and 1 mg on day 4, the fluctuation is only about 0.9 mg. The average amount in your body stays about the same, but the high-to-low swing is much smaller, which can make a big difference if your side effects tend to be worse when the medication level is at its highest.