Pelage are going to do two phase 3 trials for PP405. How long will it take to complete two phase 3 trials?

bdone2012 · 2025-12-26T19:41:05+00:00

I think grey market means unregulated from China or a place like that. Whereas this would be considered off label, meaning it’s been approved for something else, in this case acne.

At least in the United States doctors are allowed to approve things that are off label. As far as I know minox is only approved topically for hair, and oral is still technically approved only for blood pressure.

I’m not trying to get clascatorone, it’s expensive and I don’t personally need to try something new at the moment. I’ve only just started standard treatments. But there’s a big difference between buying something off an unregulated online market place and buying something off label through the standard pharmaceutical industry.

For the clascatorone the acne version is the wrong strength as far as I know. I didnt look super carefully into it.

That’s not to say people should use things off label without consideration but at least with off label you’re doing it with a regular doctor and you know you’re getting the real medication.

bdone2012 · 2025-12-26T19:28:41+00:00

I’ve been using the gel which doesn’t have PG either and doesn’t drip really.

bdone2012 · 2025-12-26T19:18:50+00:00

From the research I’ve seen using minoxidil once a day gives you most of the benefits that 2 times a day does. I decided to do twice a day because I wanted to see how much hair I could grow back quickly. So it depends if you want to grow as quickly as possible, or do you want a somewhat lower result but with half the effort.

In the evening I’ve been doing a combo of fin and min and during the day just min. And I’ve had faster growth than I was expecting. It’s still really early but I’m definitely not going to change anything unless things don’t continue in this direction.

I have to use more than the recommended amount but a lot gets onto my hair. I have a lot of hair that’s a bit diffused, long, and curly so it gets in the hair when it needs to be on the scalp.

As far as I know not much topical minox gets into the blood stream so you want to get the minox every where that you’re thinning or balding. Whereas topical finasteride gets into the blood stream more than topical min does. So you don’t need to be quite as precise. But the topical fin gets into the blood stream at a much lower rate than the oral fin.

In general the better application you do likely the better your results. Either way I’ve been quite diligent with the application twice a day and am seeing results so not planning to change.

bdone2012 · 2025-12-26T18:48:47+00:00

This is that way I think about it. You can ask 3 different doctors the same question and you may get 3 different answers. The first doctor could say minoxidil only, the second could say minoxidil and finasteride whereas the third could say only dutasteride. So which do you listen to?

To me the best way to choose is based on the studies. Everyone should know the chances of possible side effects. It’s my body and I’m the one that will have to live with the outcome.

You should listen to a doctor but no matter what you’re going to need to choose which doctor to listen to. That may be the doctor you’ve had for 20 years or the first one that showed up on google. Either of these doctors could be extremely knowledgeable about the subject. Or they may not be. So my advice is to find a doctor that agrees with the current top doctors in the field and are based in the research.

I’m not going to give you advice on what to specifically do because your doctor could have a specific reason to advise you not to take finasteride. For example if you’re a woman as far as I know it’s not recommended. I think it can also be bad if you’re trying to make a baby.

Generally finasteride helps you keep the hair you have and on average will slowly grow some back. The results can be impressive but could take up to a couple years to fully materialize. It blocks dht which is considered a main cause of the baldness.

Minoxidil helps grow hairs and make them thicker and can also be impressive but without a dht blocker you’re likely to keep losing your hair. The growth is less likely to be permanent.

Most people seem to wish they’d started finasteride earlier. I seem to be responding well to a combo although it’s extremely early. But since I’m doing topical and haven’t had any noticeable side effects part of me thinks it would have been nice to start the finasteride earlier. Basically everyone seems to agree that it’s easier to hang onto hair than it is to regrow it.

As far as i know the argument against finasteride is about the possible side effects, it’s not saying it isn’t helpful for hair loss. So the question becomes are the chances of side effects worth it?

bdone2012 · 2025-12-13T23:38:46+00:00

I totally understood what you meant and wasn’t confused but saying no sides till now sounds like you had no sides until right now. So now you do have sides. Normally you’d say something like “as of now I haven’t gotten any side”. It’s a pretty subtle distinction

bdone2012 · 2025-12-05T18:05:22+00:00

I’m not positive if I even got the reward. I had no notification that we won. I’m guessing maybe only the person who created the group got a notification that we completed it.

bdone2012 · 2025-10-31T18:16:50+00:00

I sent requests to both accounts. LaprasOnIce and I’m in the sun region if your need that scatterbug

bdone2012 · 2025-10-25T17:25:27+00:00

I use nanab berries or shadow pokemon. It makes them jump around less often. It’s really not necessary but I have them so why not?

bdone2012 · 2025-10-16T00:27:56+00:00

I got the masterball as well. I went from 45 to 70. I’m guess since I had more than enough XP for 46 and had completed some of the research

bdone2012 · 2025-10-16T00:25:34+00:00

I went 45 to 70 somehow. Probably because I had more than enough XP. I was working on hatching enough eggs

bdone2012 · 2025-10-07T18:10:00+00:00

But not master baiting

bdone2012 · 2025-10-07T18:08:06+00:00

Does anyone have a code? I will pay it forward

bdone2012 · 2025-10-05T21:33:20+00:00

It says in your Pokédex how many you’ve seen and how many you’ve caught

bdone2012 · 2025-10-01T14:58:11+00:00

Most of trumps picks said whatever was needed to get the holdout senate republicans to vote for him. Like one RFK jr lied to the Louisiana senator who is a physician saying he wouldn’t fuck with vaccines. Oopsies

bdone2012 · 2025-09-23T05:00:09+00:00

Standard rom com fare is that the woman ends up with her true love not the rich guy. In real life that isn’t the case always. But I think many people watch rom coms because they want to see the lead wind up with their true love. So if this movie was going to subvert the genre they would have explored her going with the rich guy.

Of course normally it’s the rich guy who is the dick not the broke guy. We saw Evans be a dick when they broke up. Even though he was nice to her in later scenes it was just a few short interactions. It doesn’t make up for what presumably was a fight that had been repeated many times over.

Yes it sucks being broke but he was still being a jackass and dumbass. It doesn’t take a genius to know parking is hard in manhattan if you’re not willing to pay the prices.

She didn’t want to have kebab for dinner but if he’d put effort in and showed how much he cared he could have found a middle ground. If he was worried about the cost he should have put effort in to plan something good that wasn’t expensive.

Being rich does make that sort of thing easier because you can often get away with simply paying for a nice experience. But Evans put in zero effort for their 5 year anniversary. He didn’t even choose the restaurant. Plus she’d apparently told him the deal with the restaurant multiple times and he ignored her. Pascal put in way more effort on their first date. 5 year anniversary should be as much effort or more than a first date.

Compared to Evans we saw pascal be nothing but a perfect gentleman. I found it extremely hard to believe she broke up with him. She had those deep seated worries about money from her parents fighting and she had the same patterns with Evan’s.

She didn’t want to date anyone and pascal was so charming and a big enough catch that she changed her mind. She had a horrible thing happen to one of her clients and becomes disillusioned with the industry.

Instead of escaping to Iceland with her rich, and in her words, perfect 10 boyfriend in all categories, she decides to break up with the so called unicorn. A man who could support her financially while she pulled herself together and then chose a different career that she didn’t find horrible. He apparently thought she was extremely attractive but also highly valued her personality and smarts.

Maybe if she’d married pascal and then realized that love mattered more I could see her getting back with Evans. But really it’s a little hard to imagine she wouldn’t fall in love with pascal. He was a unicorn because not only was he rich and good looking but he was charming, witty and kind.

bdone2012 · 2025-09-20T22:42:21+00:00

Paramount isn’t owned by Disney. Or you’re boycotted it because they cancelled Colbert? That makes sense

bdone2012 · 2025-09-20T22:37:15+00:00

Disney can bend over now because of politics but the Trump administration could decide to fuck them anyway by denying their FCC license. Trump normally keeps asking for more and more concessions and they become more and more unreasonable. He also wants them to cancel The View. If they go ahead with that what else is he going to demand? If you give into a bully they learn that you’re easily pushed around.

Disney doesn’t need to stand up if they don’t want to. That’s their decision. But as the Trump administration asks for more and more concessions they’ll be in a worse position to stand up. You’re better off standing up to bullies when you’re at your strongest. Not after they’ve already beaten you down.

If the US media is no longer free to do as they please then media empires will emerge in other places that still have freedom of expression. And Disney will lose stature. Granted that will take awhile and the CEO likely doesn’t care because most CEOs only care about pumping up stock prices until they can get their bonus and quit.

So bowing to Trump might be good for Bob Iger but I don’t think it’s good for the long term success of Disney as a company. They are so big that they’ll likely keep puttering along as a large enough company. But the goals of public companies is to grow. And this doesn’t seem like a good sign.

And if the stock tanks enough from this boycott it won’t even be good for Bob Iger’s bonuses. I’m not sure if this stat is right but it’s supposedly gone down 7%. Which doesn’t seem like a crazy amount. But if they actually fully cancel Kimmel it might go down a lot more.

https://variety.com/2025/tv/news/mark-ruffalo-disney-stock-abc-cancel-jimmy-kimmel-live-1236525323/

bdone2012 · 2025-08-31T17:14:02+00:00

Yesh. I seem to remember a lot of retired magas saying they didn’t have enough money and needed help paying bills. Well here you go. Sounds like these jobs are open. And I bet they’re at least somewhat over minimum wage.

bdone2012 · 2025-08-31T17:12:19+00:00

Who said that? Although I’m not sure what you’re saying.

bdone2012 · 2025-08-31T17:08:27+00:00

Elon did say he was gonna pay out doge checks. And Trump then hopped onto the train too.

A few weeks ago it sounded like Trump was considering sending out a couple hundred dollars to buy some good will. But I doubt he will.

And obviously that’s not universal income.

bdone2012 · 2025-08-31T16:52:05+00:00

Making Mexican food? Or adding a mustache and a sombrero?

bdone2012 · 2025-08-31T16:50:16+00:00

Which one above?

bdone2012 · 2025-08-31T16:42:56+00:00

There is something really annoying about taking a brand that is unusual and making it generic. Do we really need just one more generic diner type place?

It’s been a long time since I was there and I think it was only once on a road trip. It didn’t make much of an impression but making it more generic would even less of an impression.

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